Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Bryan H. Brewer"'
Autor:
Ke Weng, S. Gary Mansfield, Marcelo Amar, Colette A. Cote, Gerard J McGarrity, Alan T. Remaley, Jun Wang, Mariano A. Garcia-Blanco, Madaiah Puttaraju, Ping Du Jiang, Bryan H. Brewer
Publikováno v:
Molecular Therapy. 17:343-351
Spliceosome-mediated RNA trans-splicing has emerged as an exciting mode of RNA therapy. Here we describe a novel trans-splicing strategy, which targets highly abundant pre-mRNAs, to produce therapeutic proteins in vivo. First, we used a pre-trans-spl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff956ca44d34d8e4c440ddff467706f
https://doi.org/10.1038/mt.2008.260
https://doi.org/10.1038/mt.2008.260
Autor:
Taro E. Akiyama, Beverly Paigen, Grace L. Guo, Silvia Santamarina-Fojo, Marcelo Amar, Frank J. Gonzalez, Bryan H. Brewer
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1761:1401-1409
Farnesoid X receptor (FXR), a bile-acid-activated transcriptional factor and a member of the hormone nuclear receptor superfamily, is essential in regulating bile-acid, cholesterol, and triglyceride homeostasis. Disruption of the FXR gene in mice res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c05be7a656f3c5dc1f1d43371011fe6
https://doi.org/10.1016/j.bbalip.2006.09.018
https://doi.org/10.1016/j.bbalip.2006.09.018
Autor:
Daniel J Rader, Giacomo Ruotolo, John P Kane, Ming-Dauh Wang, Kathryn A Krueger, Steven E Nissen, Stephen J Nicholls, Bryan H Brewer
Publikováno v:
Circulation. 130
Objectives: The CETP inhibitor evacetrapib (EVA) has been shown to substantially increase HDL-C and apoA-I levels as monotherapy and combined with statins. The effects of EVA on cholesterol efflux capacity and HDL particle distribution have not been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::660e34fb10d26e0e799dc0b4270bb300
https://doi.org/10.1161/circ.130.suppl_2.12252
https://doi.org/10.1161/circ.130.suppl_2.12252
Publikováno v:
Clinica Chimica Acta. 314:131-139
Lecithin-cholesterol acyltransferase (LCAT) is the major enzyme involved in the esterification of cholesterol in circulating plasma lipoproteins. In the present study, we describe the molecular defects in the LCAT gene and in lipoprotein metabolism o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3839d3f844a3bb940630c95da07761c
https://doi.org/10.1016/s0009-8981(01)00689-1
https://doi.org/10.1016/s0009-8981(01)00689-1
Autor:
Dudley K. Strickland, Bryan H. Brewer, Judith A.K. Harmony, M Z Kounnas, Steingrimur Stefansson, W. Scott Argraves, Elena Loukinova
Publikováno v:
Journal of Biological Chemistry. 270:13070-13075
Glycoprotein 330 (gp330) is a member of a family of endocytic receptors related to the low density lipoprotein receptor. gp330 has previously been shown to bind a number of ligands in common with its family member, the low density lipoprotein recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f245d1c981013cf0c8df7cdd9a041c67
https://doi.org/10.1074/jbc.270.22.13070
https://doi.org/10.1074/jbc.270.22.13070
Autor:
Bryan H. Brewer, Tatiana Pham, Benoit Thomas, Len A. Pennacchio, Jean-Charles Fruchart, Corinne Rommens, Zouher Majd, Loredan-Stefan Niculescu, Jamila Fruchart-Najib, Eric Bauge
Publikováno v:
Biochemical and biophysical research communications. 319(2)
Overexpression of human APOA5 in mice results in dramatically decreased plasma triglyceride levels. In this study we explored the mechanism underlying this hypotriglyceridemic effect. Initially we found that triglyceride turnover was faster in hAPOA5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f835b10cf4a6579da8beb53acf86d01
https://pubmed.ncbi.nlm.nih.gov/15178420
https://pubmed.ncbi.nlm.nih.gov/15178420
Autor:
Reijiro Arakawa, Bryan H. Brewer, Alan T. Remaley, Michi Hayashi, Yoshio Yamauchi, Shinji Yokoyama
Publikováno v:
The Journal of biological chemistry. 279(8)
To investigate structural requirement of helical apolipoprotein to phosphorylate and stabilize ATP-binding cassette transporter A1 (ABCA1), synthetic peptides (Remaley, A. T., Thomas, F., Stonik, J. A., Demosky, S. J., Bark, S. E., Neufeld, E. B., Bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139067893d705a1210e08cb04f6b9fea
https://pubmed.ncbi.nlm.nih.gov/14701850
https://pubmed.ncbi.nlm.nih.gov/14701850
Publikováno v:
Metabolism: clinical and experimental. 46(10)
We have identified a 44-year-old patient with symmetrically excessive xanthomatosis, called Erdheim-Chester disease (ECD), and simultaneously decreased levels of low-density lipoprotein (LDL) cholesterol. Clinically, this patient presents lipoidgranu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a27c2267b2900e1e222113b2b7b38a
https://pubmed.ncbi.nlm.nih.gov/9322810
https://pubmed.ncbi.nlm.nih.gov/9322810
Autor:
Mariano A. Garcia-Blanco, Jun Wang, Bryan H. Brewer, Alan T. Remaley, Madaiah Puttaraju, Gerard J McGarrity
Publikováno v:
Molecular Therapy. 11:S429
Cardiovascular disease (CVD) is the most common cause of death in Western societies, and its worldwide prevalence is increasing. A very strong predictor of CVD risk is the plasma concentration of high-density lipoprotein (HDL) or of its major protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1718b155b983429aa1e4df2102cfaf32
https://doi.org/10.1016/j.ymthe.2005.07.661
https://doi.org/10.1016/j.ymthe.2005.07.661
Autor:
Robert D. Shamburek, Uwe J. F. Tietge, Bryan H. Brewer, Helen Hobbs, Herbert Lochs, Hartmut Schmidt, Loren A. Zech, Janine Genschel
Publikováno v:
Gastroenterology. 124:A59
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aefad9c9defe579adc80fb8d4bae753d
https://doi.org/10.1016/s0016-5085(03)80290-1
https://doi.org/10.1016/s0016-5085(03)80290-1