Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Bryan G. Hughes"'
Publikováno v:
MethodsX, Vol 2, Iss C, Pp 440-445 (2015)
Many types of studies require the localization of a protein to, or isolation of enriched protein from a specific cellular compartment. Many protocols in the literature and from commercially available kits claim to yield pure cellular fractions. Howev
Externí odkaz:
https://doaj.org/article/4597952dbfbd47858a05f1d6f91b2e58
Autor:
Bryan G. Hughes, Andrej Roczkowsky, Ramses Ilarraza, Nils Moser, Richard Schulz, Mathieu Poirier, Brandon Y H Chan
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 96:1238-1245
Anthracyclines, such as doxorubicin, are commonly prescribed antineoplastic agents that cause irreversible cardiac injury. Doxorubicin cardiotoxicity is initiated by increased oxidative stress in cardiomyocytes. Oxidative stress enhances intracellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c264e9f504a8fb61b8cb502529e815
https://doi.org/10.1139/cjpp-2018-0275
https://doi.org/10.1139/cjpp-2018-0275
Autor:
Bryan G Hughes, Siegfried Hekimi
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26116 (2011)
Impairments of various aspects of mitochondrial function have been associated with increased lifespan in various model organisms ranging from Caenorhabditis elegans to mice. For example, disruption of the function of the 'Rieske' iron-sulfur protein
Externí odkaz:
https://doaj.org/article/4dc3d37b5ff146c0bbc24aac0095fccd
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports
Scientific Reports
Primary ubiquinone (UQ) deficiency is an important subset of mitochondrial disease that is caused by mutations in UQ biosynthesis genes. To guide therapeutic efforts we sought to estimate the number of individuals who are born with pathogenic variant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2427efe00b14bb97daaa72f753976b48
http://link.springer.com/article/10.1038/s41598-017-17564-y
http://link.springer.com/article/10.1038/s41598-017-17564-y
Autor:
Brandon Y H Chan, Richard Schulz, Mohammed K. Ali, Bryan G. Hughes, Xiaohu Fan, Katherine Launier
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 311:H183-H189
Cardiomyocyte dedifferentiation may be an important source of proliferating cardiomyocytes facilitating cardiac repair. Cardiomyocyte dedifferentiation and proliferation induced by oncostatin-M (OSM) is characterized by sarcomere degeneration. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6c926d3147b55f1df98986033026a0
https://doi.org/10.1152/ajpheart.00229.2016
https://doi.org/10.1152/ajpheart.00229.2016
Publikováno v:
Journal of Molecular and Cellular Cardiology. 94:153-161
Matrix metalloproteinases (MMPs) are zinc-dependent proteases involved in intra- and extra-cellular matrix remodeling resulting from oxidative stress injury to the heart. MMP-2 was the first MMP to be localized to the nucleus; however, its biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e6dbc586bebdb47d1112ee9d515a1f
https://doi.org/10.1016/j.yjmcc.2016.04.004
https://doi.org/10.1016/j.yjmcc.2016.04.004
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 306:H764-H770
Matrix metalloproteinase-2 (MMP-2) has been extensively studied in the context of extracellular matrix remodeling but is also localized within cells and can be activated by prooxidants to proteolyze specific intercellular targets. Although there are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62362e55b4625113979b247b69f7f4cd
https://doi.org/10.1152/ajpheart.00909.2013
https://doi.org/10.1152/ajpheart.00909.2013
Autor:
Siegfried Hekimi, Bryan G. Hughes
Mouse and Caenorhabditis elegans mutants with altered life spans are being used to investigate the aging process and how genes determine life span. The survival of a population can be modeled by the Gompertz function, which comprises two parameters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc12a8de73098b1d8d571305da03809c
https://europepmc.org/articles/PMC5105868/
https://europepmc.org/articles/PMC5105868/
Autor:
Bryan G. Hughes, Siegfried Hekimi
Publikováno v:
Nature. 546:E8-E9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d6b22b5fabf3340cb032aa795002f5
https://doi.org/10.1038/nature22786
https://doi.org/10.1038/nature22786
Publikováno v:
The FASEB Journal. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4617e0bd7c999b393fca26681500ae58
https://doi.org/10.1096/fasebj.29.1_supplement.979.6
https://doi.org/10.1096/fasebj.29.1_supplement.979.6