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Akademický článek

Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer’s disease brain

Autor: Bryan Frey, David Holzinger, Keenan Taylor, Dagmar E. Ehrnhoefer, Andreas Striebinger, Sandra Biesinger, Laura Gasparini, Michael J. O’Neill, Florian Wegner, Stefan Barghorn, Günter U. Höglinger, Roland G. Heym

Publikováno v: Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-17 (2023)

Abstract Tau seed amplification assays (SAAs) directly measure the seeding activity of tau and would therefore be ideal biomarkers for clinical trials targeting seeding-competent tau in Alzheimer’s disease (AD). However, the precise relationship be

Externí odkaz: https://doaj.org/article/78bf1f0ec959455f9e1ccbfb0ccf720b

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Akademický článek

Correction: Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer's disease brain.

Autor: Frey, Bryan^1,2,3 (AUTHOR) bryan.frey@abbvie.com, Holzinger, David¹ (AUTHOR), Taylor, Keenan⁴ (AUTHOR), Ehrnhoefer, Dagmar E.¹ (AUTHOR), Striebinger, Andreas¹ (AUTHOR), Biesinger, Sandra¹ (AUTHOR), Gasparini, Laura¹ (AUTHOR), O'Neill, Michael J.¹ (AUTHOR), Wegner, Florian^2,3 (AUTHOR), Barghorn, Stefan¹ (AUTHOR), Höglinger, Günter U.^2,3,5,6 (AUTHOR), Heym, Roland G.¹ (AUTHOR) roland.heym@abbvie.com

Publikováno v: Acta Neuropathologica Communications. 7/15/2024, Vol. 12 Issue 1, p1-1. 1p.

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Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: what you see is not always what you get

Autor: Bryan Frey, Matthew P. Jackson, James A. Duce, Abdelrahman AlOkda, Nathan Riguet, Hilal A. Lashuel

Publikováno v: Journal of Neurochemistry

Bimolecular fluorescence complementation (BiFC) was introduced a decade ago as a method to monitor alpha‐synuclein (α‐syn) oligomerization in intact cells. Since then, several α‐syn BiFC cellular assays and animal models have been developed b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d467fb3fc814c02d6deeda6422fcfe