Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Bryan F Cox"'
Autor:
Diwakar Davar, Yujia Liu, Jason Laporte, Prajna Guha, Steven C Katz, Chandra C Ghosh, Lauren Cournoyer, Alizee Ballarin, Ilan B Layman, Molly Morrissey, Kayla Fraser, Shriya Perati, Bryan F Cox, Evgeny Yakirevich, Diana O Treaba, Timothy D Murtha
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Background Toll-like receptor 9 (TLR9) agonists induce inflammatory responses that promote the killing of infectious micro-organisms, cancer cells and develop adaptive immune responses. Their ability as immunomodulators to enhance the activity of che
Externí odkaz:
https://doaj.org/article/a44effbe99ed410eaeba499fe1a1625d
Autor:
Marcin Klapczynski, Gerard D Gagne, Sherry J Morgan, Kelly J Larson, Bruce E LeRoy, Eric A Blomme, Bryan F Cox, Eugene W Shek
Publikováno v:
Journal of Pathology Informatics, Vol 3, Iss 1, Pp 20-20 (2012)
Introduction: Surgical 5/6 nephrectomy and adenine-induced kidney failure in rats are frequently used models of progressive renal failure. In both models, rats develop significant morphological changes in the kidneys and quantification of these chang
Externí odkaz:
https://doaj.org/article/c2b9fec2541e4b119c6d0067d07d3693
Autor:
Louis F. Chai, John C. Hardaway, Kara R. Heatherton, Kyle P. O’Connell, Mikayla C. Lopes, Benjamin A. Rabinowitz, Chandra C. Ghosh, Prajna Guha, David Jaroch, Bryan F. Cox, Steven C. Katz
Publikováno v:
Vaccines, Vol 9, Iss 8, p 807 (2021)
Metastatic liver tumors have presented challenges with the use of checkpoint inhibitors (CPIs), with only limited success. We hypothesize that regional delivery (RD) of CPIs can improve activity in the liver and minimize systemic exposure, thereby re
Externí odkaz:
https://doaj.org/article/6fb5f456cae4492f8c6c1e505c93455d
Autor:
Chandra C. Ghosh, Kara R. Heatherton, Kyle P. O’ Connell, Ian S. Alexander, Deborah A. Greer, Jason LaPorte, Prajna Guha, Bryan F. Cox, Steven C. Katz
Publikováno v:
Cancer Gene Therapy. 29:1854-1865
Myeloid-derived suppressor cells (MDSCs) expand in response to malignancy and suppress responsiveness to immunotherapy, including checkpoint inhibitors (CPIs). Within the liver, MDSCs have unique immunosuppressive features. While TLR9 agonists have s
Autor:
Louis F. Chai, John C. Hardaway, Kara R. Heatherton, Kyle P. O'Connell, Jason P. LaPorte, Prajna Guha, Mikayla C. Lopes, Benjamin A. Rabinowitz, David Jaroch, Bryan F. Cox, Robert Knight, Steven C. Katz
Publikováno v:
Journal of Surgical Research. 272:37-50
Effective treatment of solid tumors requires multi-modality approaches. In many patients with stage IV liver disease, current treatments are not curative. Chimeric antigen receptor T cells (CAR-T) are an intriguing option following success in hematol
Autor:
Louis F. Chai, John C. Hardaway, Kara R. Heatherton, Kyle P. O’Connell, Jason P. LaPorte, Prajna Guha, Abdul Saied, Robert Knight, David Jaroch, Bryan F. Cox, Steven C. Katz
Publikováno v:
The Journal of Immunology. 204:170.8-170.8
Introduction Efficacy of cellular immunotherapy for liver metastases (LM) has been limited by poor trafficking and elevated intra-tumoral pressures. In a phase 1b study, we found that regional, pressure-enabled drug delivery (PEDD, TriSalus Life Scie
Characterization of A-935142, a hERG enhancer, in the presence and absence of standard hERG blockers
Autor:
Bryan F. Cox, Xiaoqin Liu, Gary A. Gintant, James T. Limberis, Gilbert Diaz, Ruth L. Martin, Kathryn Houseman, Zhi Su
Publikováno v:
Life Sciences. 90:607-611
Aims In a previous study we found that A-935142 enhanced hERG current in a concentration-dependent manner by facilitating activation, reducing inactivation, and slowing deactivation (Su et al., 2009). A-935142 also shortened action potential duration
Autor:
Andrew J. King, Jerome F. Daanen, Richard A. Nelson, Nathan L. Lubbers, Bryan F. Cox, James J. Lynch, Philip R. Kym, Michael E. Kort, Scott W. Mittelstadt
Publikováno v:
Blood Coagulation & Fibrinolysis. 23:94-97
Capsaicin is an agonist of transient receptor potential vanilloid type 1 (TRPV1), in which it can act as a neuronal stimulant and result in nociception. Capsaicin also affects a variety of nonneuronal tissues, in which its mechanisms of action are le
Autor:
Gerard B. Fox, Mark Day, Feng Luo, Ulrich Ebert, Vincent Hradil, Terese Seifert, Bryan F. Cox, Beate Roesner, Jean M. Severin, Heinz Hillen, Daniel A. Llano, Nathan R. Rustay
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 335:580-588
In recent years immunotherapy-based approaches for treating Alzheimer's disease have become the subject of intensive research. However, an important mechanistic-related safety concern is exacerbation of the risk of microhemorrhage that may be associa
Autor:
Bryan F. Cox, David Frost, Yanping Luo, Gerard D. Gagne, Gerard B. Fox, Saul H. Rosenberg, Gary Gordon, Vincent P. Hradil, Sherry J. Morgan, Stephen K. Tahir
Publikováno v:
Anti-Cancer Drugs. 20:483-492
ABT-751 is an orally bioavailable tubulin-binding agent that is currently under clinical development for cancer treatment. In preclinical studies, ABT-751 showed antitumor activity against a broad spectrum of tumor lines including those resistant to