Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Bryan E. Thacker"'
Autor:
Susan L. Lindsay, Rebecca Sherrard Smith, Edwin A. Yates, Colin Cartwright, Bryan E. Thacker, Jeremy E. Turnbull, Charles A. Glass, Susan C. Barnett
Publikováno v:
Biology, Vol 12, Iss 3, p 407 (2023)
Therapies that target the multicellular pathology of central nervous system (CNS) disease/injury are urgently required. Modified non-anticoagulant heparins mimic the heparan sulphate (HS) glycan family and have been proposed as therapeutics for CNS r
Externí odkaz:
https://doaj.org/article/1e07cdcdee96451c90a68e210f467151
Autor:
Ryan N. Porell, Julianna L. Follmar, Sean C. Purcell, Bryce Timm, Logan K. Laubach, David Kozirovskiy, Bryan E. Thacker, Charles A. Glass, Philip L. S. M. Gordts, Kamil Godula
Publikováno v:
ACS Chemical Biology. 17:1534-1542
Glycosaminoglycans (GAGs) are a class of highly negatively charged membrane-associated and extracellular matrix polysaccharides involved in the regulation of myriad biological functions, including cell adhesion, migration, signaling, and differentiat
Autor:
Bryan E. Thacker, Kristen J. Thorne, Colin Cartwright, Jeeyoung Park, Kimberly Glass, Annie Chea, Benjamin P. Kellman, Nathan E. Lewis, Zhenping Wang, Anna Di Nardo, Susan T. Sharfstein, Walter Jeske, Jeanine Walenga, John Hogwood, Elaine Gray, Barbara Mulloy, Jeffrey D. Esko, Charles A. Glass
Publikováno v:
Metabolic Engineering. 70:155-165
Heparin is an essential anticoagulant used for treating and preventing thrombosis. However, the complexity of heparin has hindered the development of a recombinant source, making its supply dependent on a vulnerable animal population. In nature, hepa
Autor:
Miguel Tillo, William C. Lamanna, Chrissa A. Dwyer, Daniel R. Sandoval, Ariane R. Pessentheiner, Norah Al-Azzam, Stéphane Sarrazin, Jon C. Gonzales, Shih-Hsin Kan, Alexander Y. Andreyev, Nicholas Schultheis, Bryan E. Thacker, Charles A. Glass, Patricia I. Dickson, Raymond Y. Wang, Scott B. Selleck, Jeffrey D. Esko, Philip L.S.M. Gordts
Publikováno v:
The Journal of biological chemistry, vol 298, iss 8
Lysosomal storage diseases result in various developmental and physiological complications, including cachexia. To study the causes for the negative energy balance associated with cachexia, we assessed the impact of sulfamidase deficiency and heparan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aac85804ae2331b1d014955f84e8ad4
https://escholarship.org/uc/item/90c4v3np
https://escholarship.org/uc/item/90c4v3np
Autor:
Ryan N. Porell, Sandra L Leibel, Jonathan L. Torres, Chelsea D. Painter, Aaron F. Carlin, Aaron F. Garretson, Gregory J. Golden, Elizabeth M. Kwong, Rachael N. McVicar, Timothy M. Caradonna, Philip L.S.M. Gordts, Andrew B. Ward, Sumit K. Chanda, Daniel R. Sandoval, Zhang Yang, Benjamin P. Kellman, Blake M. Hauser, Charles A. Glass, Jessica Pihl, Kevin D. Corbett, Joyce Jose, Cameron Martino, Sydney A. Majowicz, Jeffrey D. Esko, Charlotte B Spliid, Xin Yin, Bryan E. Thacker, Aaron G. Schmidt, Anoop Narayanan, Kamil Godula, Hailee R. Perrett, Jared Feldman, Logan K. Laubach, Phillip L. Bartels, Thomas Mandel Clausen, Yuan Pu
Publikováno v:
Cell, vol 183, iss 4
Cell
Cell
We show that SARS-CoV-2 spike protein interacts with both cellular heparan sulfate and angiotensin-converting enzyme 2 (ACE2) through its receptor-binding domain (RBD). Docking studies suggest a heparin/heparan sulfate-binding site adjacent to the AC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a75e2afde17a8be9e8115c9a6dd2ee6
https://escholarship.org/uc/item/232927v1
https://escholarship.org/uc/item/232927v1
Autor:
Aaron G. Schmidt, Gordts, Plsm, Chanda, S. K., Cameron Martino, Blake M. Hauser, Thomas Mandel Clausen, Yuan Pu, Sydney A. Majowicz, Rachael N. McVicar, Charlotte B Spliid, Sandra L Leibel, Xin Yin, Daniel R. Sandoval, Jonathan L. Torres, Benjamin P. Kellman, Timothy M. Caradonna, E. M. Kwong, Ryan N. Porell, Kamil Godula, Charles A. Glass, Aaron F. Carlin, Bryan E. Thacker, Jessica Pihl, Kevin D. Corbett, Andrew B. Ward, Jared Feldman, Hailee R. Perrett, Jeffrey D. Esko, Logan K. Laubach, Chelsea D. Painter, Anoop Narayanan, Phillip L. Bartels, Aaron F. Garretson, Gregory J. Golden, Joyce Jose, Zhang Yang
Publikováno v:
bioRxiv
We show that SARS-CoV-2 spike protein interacts with cell surface heparan sulfate and angiotensin converting enzyme 2 (ACE2) through its Receptor Binding Domain. Docking studies suggest a putative heparin/heparan sulfate-binding site adjacent to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a9950cb2eacc5605613b031b210508
https://europepmc.org/articles/PMC7373134/
https://europepmc.org/articles/PMC7373134/
Autor:
Bryan E. Thacker, Susan T. Sharfstein
Publikováno v:
Emerging Topics in Life Sciences. 2:443-452
Heparan sulfate (HS) is a glycosaminoglycan produced by all mammalian cells that plays important roles in physiology and various pathologies. Heparin is a highly sulfated form of HS that is used clinically as an anticoagulant. Heparin and HSs may als
Autor:
Philip L.S.M. Gordts, Stéphane Sarrazin, Yitzhak Tor, Gentry N. Patrick, Wenyong Tong, Lara E. Dozier, Chrissa A. Dwyer, Jeffrey D. Esko, Jillian R. Brown, Bryan E. Thacker, Kristina M. Hamill, Kelley W. Moremen, Charles A. Glass
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy, vol 25, iss 12
Iduronidase (IDUA)-deficient mice accumulate glycosaminoglycans in cells and tissues and exhibit many of the same neuropathological symptoms of patients suffering from Mucopolysaccharidosis I. Intravenous enzyme-replacement therapy forMucopolysacchar
Autor:
Emylie Seamen, Matthew W. Parker, Roger Lawrence, Jian Liu, Yongmei Xu, Craig W. Vander Kooi, Bryan E. Thacker, Jeffrey D. Esko
Publikováno v:
ACS Chemical Biology. 11:971-980
Binding of proteins to heparan sulfate is driven predominantly by electrostatic interactions between positively charged amino acid residues in the protein and negatively charged sulfate groups located at various positions along the polysaccharide cha
Autor:
Steven Q. Le, Bryan E. Thacker, Farhan A. Hussain, Patricia I. Dickson, Charles A. Glass, Jeffrey D. Esko, Jillian R. Brown
Publikováno v:
Molecular Genetics and Metabolism. 129:S35