Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Bryan E, Snow"'
Autor:
Shawn P. Kubli, Larsen Vornholz, Gordon Duncan, Wenjing Zhou, Parameswaran Ramachandran, Jerome Fortin, Maureen Cox, SeongJun Han, Robert Nechanitzky, Duygu Nechanitzky, Bryan E. Snow, Lisa Jones, Wanda Y. Li, Jillian Haight, Andrew Wakeham, Mark R. Bray, Tak W. Mak
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Myeloid cells modulate the immune response within the tumour microenvironment, but the underlying mechanisms remain largely unknown. Here, the authors show that Fcmr – the putative receptor for soluble IgM – is a potent negative regulator of anti
Externí odkaz:
https://doaj.org/article/249fbfe56ab6438d997eb47907be7294
Autor:
Robert Nechanitzky, Duygu Nechanitzky, Parameswaran Ramachandran, Gordon S. Duncan, Chunxing Zheng, Christoph Göbl, Kyle T. Gill, Jillian Haight, Andrew C. Wakeham, Bryan E. Snow, Vivian Bradaschia-Correa, Milan Ganguly, Zhibin Lu, Mary E. Saunders, Richard A. Flavell, Tak W. Mak
Publikováno v:
Cell Death & Differentiation. 30:407-416
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d29775db094dada32286064ab261fa80
https://doi.org/10.1038/s41418-022-01092-y
https://doi.org/10.1038/s41418-022-01092-y
Autor:
Zhenyue Hao, Yi Sheng, Gordon S. Duncan, Wanda Y. Li, Carmen Dominguez, Jennifer Sylvester, Yu-Wen Su, Gloria H.Y. Lin, Bryan E. Snow, Dirk Brenner, Annick You-Ten, Jillian Haight, Satoshi Inoue, Andrew Wakeham, Alisha Elford, Sara Hamilton, Yi Liang, Juan C. Zúñiga-Pflücker, Housheng Hansen He, Pamela S. Ohashi, Tak W. Mak
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
The E3 ligase Mule has been previously reported to be essential for B cell development and function by modulating p53 ubiquitination and degradation. Here Haoet al. identify KLF4 as a novel ubiquitination target of Mule and show it controls T cell pr
Externí odkaz:
https://doaj.org/article/e6eb6c78746d4519b89d713cb4a6a1dc
Autor:
Shawn P. Kubli, Larsen Vornholz, Gordon Duncan, Wenjing Zhou, Parameswaran Ramachandran, Jerome Fortin, Maureen Cox, SeongJun Han, Robert Nechanitzky, Duygu Nechanitzky, Bryan E. Snow, Lisa Jones, Wanda Y. Li, Jillian Haight, Andrew Wakeham, Mark R. Bray, Tak W. Mak
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/75fabd1ca5c3402c819e4a294285652c
Autor:
Jun Gui, Angelica Ortiz, Cindy Sander, Leslie Todd, J. Alan Diehl, Sandra Ryeom, Dmitry I. Gabrilovich, Christina Cho, John M. Kirkwood, Kevin Alicea-Torres, Jinyang Li, Andrew Wakeham, Kanstantsin V. Katlinski, Bryan E. Snow, Ben Z. Stanger, Daniel P. Beiting, Hongru Zhang, Farima Zahedi, Serge Y. Fuchs, Tak W. Mak, Ellen Puré, Constantinos Koumenis
Publikováno v:
Nature Cancer. 1:603-619
Primary tumor-derived factors act upon normal cells to generate a pre-metastatic niche, which promotes colonization of target organs by disseminated malignant cells. Here we report that tumor-derived factor-induced activation of the p38α kinase in l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5cb185b1f3b5acff662a49155baaff
https://doi.org/10.1038/s43018-020-0064-0
https://doi.org/10.1038/s43018-020-0064-0
Autor:
Sabelo, Lukhele, Diala Abd, Rabbo, Mengdi, Guo, Jian, Shen, Heidi J, Elsaesser, Rene, Quevedo, Madeleine, Carew, Ramy, Gadalla, Laura M, Snell, Lawanya, Mahesh, M Teresa, Ciudad, Bryan E, Snow, Annick, You-Ten, Jillian, Haight, Andrew, Wakeham, Pamela S, Ohashi, Tak W, Mak, Weiguo, Cui, Tracy L, McGaha, David G, Brooks
Publikováno v:
Immunity. 55(12)
Type I and II interferons (IFNs) stimulate pro-inflammatory programs that are critical for immune activation, but also induce immune-suppressive feedback circuits that impede control of cancer growth. Here, we sought to determine how these opposing p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb8d4c32b046cb404482dc3e551e1fac
https://pubmed.ncbi.nlm.nih.gov/36370712
https://pubmed.ncbi.nlm.nih.gov/36370712
Autor:
Parameswaran Ramachandran, Vuk Stambolic, Jerome Fortin, Ruxiao Tian, Wanda Y. Li, Kelsey Hodgson, Graham Hill, Tak W. Mak, Jillian Haight, Ida Zarrabi, Andrew Wakeham, Bryan E. Snow, Christian Bassi, Chantal Tobin
Publikováno v:
J Clin Invest
In order to sustain proficient life-long hematopoiesis, hematopoietic stem cells (HSCs) must possess robust mechanisms to preserve their quiescence and genome integrity. DNA-damaging stress can perturb HSC homeostasis by affecting their survival, sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a035272631d4cfb5e3b2d3920978460e
https://doi.org/10.1172/jci131698
https://doi.org/10.1172/jci131698
Autor:
Luke N. Buckler, Emily Cianci, Bryan E. Snow, Tak Wah Mak, Jason Ho, Vuk Stambolic, Chiara Gorrini, Jerome Fortin, Jillian Haight, Christian Bassi, Andrew Wakeham, Annick You-Ten
Publikováno v:
Cell Death and Differentiation
The tumor suppressor PTEN is disrupted in a large proportion of cancers, including in HER2-positive breast cancer, where its loss is associated with resistance to therapy. Upon genotoxic stress, ataxia telangiectasia mutated (ATM) is activated and ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e50f5bd81e15390f56b61c470d5cdca
https://pubmed.ncbi.nlm.nih.gov/34059798
https://pubmed.ncbi.nlm.nih.gov/34059798
Autor:
Jillian Haight, Graham Hill, Parameswaran Ramachandran, Jerome Fortin, Cynthia Hawkins, Jong Fu Wong, David J. Goldhamer, Peter ten Dijke, Eleanor Williams, Tak W. Mak, Daniel Schramek, Andrew Wakeham, Annette Wu, Gonzalo Sanchez-Duffhues, Ida Zarrabi, Lorraine N. Apuzzo, Bryan E. Snow, Annick You-Ten, Midory Thorikay, Alex N. Bullock, Ruxiao Tian, Robert Siddaway
Publikováno v:
Cancer Cell, 37(3), 308-323.e12. CELL PRESS
Cancer Cell
Cancer Cell
Summary Diffuse intrinsic pontine gliomas (DIPGs) are aggressive pediatric brain tumors for which there is currently no effective treatment. Some of these tumors combine gain-of-function mutations in ACVR1, PIK3CA, and histone H3-encoding genes. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef3cee7b858e98ad06f8fa54953e839
https://doi.org/10.1016/j.ccell.2020.02.002
https://doi.org/10.1016/j.ccell.2020.02.002
Autor:
Lisa Jones, Bryan E. Snow, Mark R. Bray, Tak W. Mak, Jerome Fortin, Wenjing Zhou, Parameswaran Ramachandran, Larsen Vornholz, SeongJun Han, Wanda Y. Li, Jillian Haight, Shawn P. Kubli, Duygu Nechanitzky, Andrew Wakeham, Maureen A. Cox, Robert Nechanitzky, Gordon Duncan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Myeloid cells contribute to tumor progression, but how the constellation of receptors they express regulates their functions within the tumor microenvironment (TME) is unclear. We demonstrate that Fcmr (Toso), the putative receptor for soluble IgM, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0357b8caa3c0e7741ffc05d06e14d407
https://doi.org/10.1038/s41467-019-10619-w
https://doi.org/10.1038/s41467-019-10619-w