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pro vyhledávání: '"Bryan D. Tarr"'
Effect of body size on the uptake and bioconcentration of di-2-ethylhexyl phthalate in rainbow trout
Publikováno v:
Environmental Toxicology and Chemistry. 9:989-995
Three groups of rainbow trout (Salmo gairdneri) having average body weights of 2.9, 61 and 440 g were exposed at 12°C by the water to di-2-ethylhexyl phthalate (DEHP). The kinetics of uptake and bioconcentration were characterized in each group usin
Publikováno v:
Pharmaceutical Research. :162-165
Taxol (NSC-125973) is a poorly soluble plant product that exhibits excellent antimitotic properties. This study involves the development of a new formulation for taxol. The stability of taxol in a 50% triacetin emulsion as well as possible methods of
Publikováno v:
Toxicology and Applied Pharmacology. 88:305-312
Rainbow trout (Salmo gairdneri) acclimated at 6, 12, or 18°C received 400 μg [14C]DEHP/kg as an intraaortic bolus. DEHP disappeared rapidly from plasma, with an estimated 50% of the dose eliminated after 5 hr. Plasma concentration-time data were an
Autor:
Bryan D. Tarr, Samuel H. Yalkowsky
Publikováno v:
Pharmaceutical Research. :40-43
The intestinal absorption of cyclosporine was measured in situ in rats using an olive oil emulsion prepared by either stirring or homogenization. The surface area of the homogenized dosage form was twice that of the stirred dosage form. The apparent
Publikováno v:
Journal of Fish Biology. 31:735-744
Cardiac output, blood flow distribution and regional perfusion were determined in free-swimming rainbow trout acclimated to 6, 12 and 18°C, using the indicator dilution and microsphere methods. Cardiac output (ml min−1 kg−1) increased linearly w