Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Bryan D Moyer"'
Autor:
Bryan D Moyer, Justin K Murray, Joseph Ligutti, Kristin Andrews, Philippe Favreau, John B Jordan, Josie H Lee, Dong Liu, Jason Long, Kelvin Sham, Licheng Shi, Reto Stöcklin, Bin Wu, Ruoyuan Yin, Violeta Yu, Anruo Zou, Kaustav Biswas, Les P Miranda
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0196791 (2018)
Identification of voltage-gated sodium channel NaV1.7 inhibitors for chronic pain therapeutic development is an area of vigorous pursuit. In an effort to identify more potent leads compared to our previously reported GpTx-1 peptide series, electrophy
Externí odkaz:
https://doaj.org/article/05d6c798f5064771a7180e9f1fa3d097
Autor:
Jacinthe Gingras, Sarah Smith, David J Matson, Danielle Johnson, Kim Nye, Lauren Couture, Elma Feric, Ruoyuan Yin, Bryan D Moyer, Matthew L Peterson, James B Rottman, Rudolph J Beiler, Annika B Malmberg, Stefan I McDonough
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e105895 (2014)
Clinical genetic studies have shown that loss of Nav1.7 function leads to the complete loss of acute pain perception. The global deletion is reported lethal in mice, however, and studies of mice with promoter-specific deletions of Nav1.7 have suggest
Externí odkaz:
https://doaj.org/article/49c66d94391141b6b07f7e6d7d29e53b
Autor:
Bryan D Moyer, Peter Hevezi, Na Gao, Min Lu, Dalia Kalabat, Hortensia Soto, Fernando Echeverri, Bianca Laita, Shaoyang Anthony Yeh, Mark Zoller, Albert Zlotnik
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e7682 (2009)
BackgroundUsing fungiform (FG) and circumvallate (CV) taste buds isolated by laser capture microdissection and analyzed using gene arrays, we previously constructed a comprehensive database of gene expression in primates, which revealed over 2,300 ta
Externí odkaz:
https://doaj.org/article/05348aff99054d6581aa73ab64d722fa
Autor:
Peter Hevezi, Bryan D Moyer, Min Lu, Na Gao, Evan White, Fernando Echeverri, Dalia Kalabat, Hortensia Soto, Bianca Laita, Cherry Li, Shaoyang Anthony Yeh, Mark Zoller, Albert Zlotnik
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6395 (2009)
Efforts to unravel the mechanisms underlying taste sensation (gustation) have largely focused on rodents. Here we present the first comprehensive characterization of gene expression in primate taste buds. Our findings reveal unique new insights into
Externí odkaz:
https://doaj.org/article/b99db95f5a754e39852dc04b9aed6a97
Autor:
John R, Butler, Gwenaella, Rescourio, Benjamin C, Milgram, Robert S, Foti, Thomas, Kornecook, Joseph, Ligutti, Bryan D, Moyer, Kristin, Taborn, Beth D, Youngblood, Violeta, Yu, Roman, Shimanovich, Alessandro, Boezio, Matthew, Weiss
Publikováno v:
Bioorganicmedicinal chemistry letters. 73
Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::026ead5bb43373a0b3209260097690d4
https://pubmed.ncbi.nlm.nih.gov/35850422
https://pubmed.ncbi.nlm.nih.gov/35850422
Autor:
Owen B. McManus, Vivian Hecht, Violeta Yu, Chris M Hempel, Graham T. Dempsey, Ryan J. Babcock, Michael Jarosh, Joseph G. McGivern, Hongkang Zhang, Kevin Dong, Bryan D. Moyer, Christopher A. Werley
Publikováno v:
SLAS Discovery. 25:434-446
The voltage-gated sodium channel Nav1.7 is a genetically validated target for pain; pharmacological blockers are promising as a new class of nonaddictive therapeutics. The search for Nav1.7 subtype selective inhibitors requires a reliable, scalable,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b158bb79b66d537a5d39c6d8bdd18fe7
https://doi.org/10.1177/2472555220914532
https://doi.org/10.1177/2472555220914532
Autor:
Licheng Shi, Bryan D. Moyer, Margarida Martins-Oliveira, Hong Sun, Sonya G. Lehto, Peter J. Goadsby, Simon Akerman, Jan Hoffmann, Dawn Zhu, Weera Supronsinchai, Ruoyuan Yin, Cen Xu, Silke Miller, Judy Wang, Hantao Liu
Publikováno v:
Hoffmann, J R, Miller, S, Martins-Oliveira, M, Akerman, S, Supronsinchai, W, Sun, H, Shi, L, Wang, J, Zhu, D, Lehto, S, Liu, H, Yin, R, Moyer, B D, Xu, C & Goadsby, P 2020, ' PAC1 receptor blockade reduces central nociceptive activity: new approach for primary headache? ', Pain, vol. 161, no. 7, pp. 1670-1681 . https://doi.org/10.1097/j.pain.0000000000001858
Pain
Pain
PAC1 receptor blockade using a monoclonal antibody inhibits nociceptive neuronal activity in the trigeminocervical complex.
Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) may play an important role in primary headaches. Preclini
Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) may play an important role in primary headaches. Preclini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e0f35bc013beddca80233ef15c9e0b8
https://doi.org/10.1097/j.pain.0000000000001858
https://doi.org/10.1097/j.pain.0000000000001858
Autor:
Brad Herberich, Thomas Nixey, Lin Yin, Tayo Ikotun, Kelvin K. C. Sham, Jason Long, Hongyan Li, Charles Glaus, Xuhai Be, Les P. Miranda, Yuan Cheng, Marcus Soto, James R. Falsey, Bryan D. Moyer, Robert S. Foti, Christopher M. Tegley, Chawita Netirojjanakul, Linh Tran, Kip P. Conner, Jennifer Aral, Liyue Huang, Kaustav Biswas, Justin K. Murray, Bin Wu, Loren Berry, Dean Hickman, Dan A. Rock
Publikováno v:
Drug Metabolism and Disposition. 47:1111-1121
The identification of nonopioid alternatives to treat chronic pain has received a great deal of interest in recent years. Recently, the engineering of a series of Nav1.7 inhibitory peptide-antibody conjugates has been reported, and herein, the precli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aafa704103c2cd45fe6f198cffc5d5f
https://doi.org/10.1124/dmd.119.087742
https://doi.org/10.1124/dmd.119.087742
Autor:
Bryan D. Moyer, Brad Herberich, Kaustav Biswas, Kenneth W. Walker, Beth D. Youngblood, Jennifer Aral, Tayo Ikotun, Min-Hwa Jasmine Lin, Linh Tran, Thomas Kornecook, Hongyan Li, Thomas Nixey, Joseph Ligutti, Shanti Amagasu, Li Yin, Xuhai Be, Kristin L. Andrews, Christopher M. Tegley, Charles Glaus, Marcus Soto, Les P. Miranda, James R. Falsey, Jason Long, Yuan Cheng, Robert S. Foti, Hossein Salimi-Moosavi, Kelvin Sham, Christopher P Ilch, Bin Wu, Justin K. Murray, Margaret Karow, Chawita Netirojjanakul, Liz Doherty
Publikováno v:
ACS Chemical Biology. 14:806-818
Drug discovery research on new pain targets with human genetic validation, including the voltage-gated sodium channel NaV1.7, is being pursued to address the unmet medical need with respect to chronic pain and the rising opioid epidemic. As part of e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68d1aa4016111a37796e962e98dcd944
https://doi.org/10.1021/acschembio.9b00183
https://doi.org/10.1021/acschembio.9b00183
