Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Bryan D Kynnap"'
Autor:
Andrew L Hong, Yuen-Yi Tseng, Jeremiah A Wala, Won-Jun Kim, Bryan D Kynnap, Mihir B Doshi, Guillaume Kugener, Gabriel J Sandoval, Thomas P Howard, Ji Li, Xiaoping Yang, Michelle Tillgren, Mahmhoud Ghandi, Abeer Sayeed, Rebecca Deasy, Abigail Ward, Brian McSteen, Katherine M Labella, Paula Keskula, Adam Tracy, Cora Connor, Catherine M Clinton, Alanna J Church, Brian D Crompton, Katherine A Janeway, Barbara Van Hare, David Sandak, Ole Gjoerup, Pratiti Bandopadhayay, Paul A Clemons, Stuart L Schreiber, David E Root, Prafulla C Gokhale, Susan N Chi, Elizabeth A Mullen, Charles WM Roberts, Cigall Kadoch, Rameen Beroukhim, Keith L Ligon, Jesse S Boehm, William C Hahn
Publikováno v:
eLife, Vol 8 (2019)
Renal medullary carcinoma (RMC) is a rare and deadly kidney cancer in patients of African descent with sickle cell trait. We have developed faithful patient-derived RMC models and using whole-genome sequencing, we identified loss-of-function intronic
Externí odkaz:
https://doaj.org/article/ea9c3a1d96864bb8bbdbc626e575f019
Autor:
Karuna Mittal, Garrett W. Cooper, Benjamin P. Lee, Yongdong Su, Katie T. Skinner, Jenny Shim, Hunter C. Jonus, Won Jun Kim, Mihir Doshi, Diego Almanza, Bryan D. Kynnap, Amanda L. Christie, Xiaoping Yang, Glenn S. Cowley, Brittaney A. Leeper, Christopher L. Morton, Bhakti Dwivedi, Taylor Lawrence, Manali Rupji, Paula Keskula, Stephanie Meyer, Catherine M. Clinton, Manoj Bhasin, Brian D. Crompton, Yuen-Yi Tseng, Jesse S. Boehm, Keith L. Ligon, David E. Root, Andrew J. Murphy, David M. Weinstock, Prafulla C. Gokhale, Jennifer M. Spangle, Miguel N. Rivera, Elizabeth A. Mullen, Kimberly Stegmaier, Kelly C. Goldsmith, William C. Hahn, Andrew L. Hong
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Wilms tumor (WT) is the most common renal malignancy of childhood. Despite improvements in the overall survival, relapse occurs in ~15% of patients with favorable histology WT (FHWT). Half of these patients will succumb to their disease. Ide
Externí odkaz:
https://doaj.org/article/0c944d44150c49a0b8aca89a9d8db85d
Autor:
Nithya Kartha, Jessica E. Gianopulos, Zachary Schrank, Sarah M. Cavender, Stephanie Dobersch, Bryan D. Kynnap, Adrianne Wallace-Povirk, Cynthia L. Wladyka, Juan F. Santana, Jaeseung C. Kim, Angela Yu, Caroline M. Bridgwater, Kathrin Fuchs, Sarah Dysinger, Aaron E. Lampano, Faiyaz Notta, David H. Price, Andrew C. Hsieh, Sunil R. Hingorani, Sita Kugel
Publikováno v:
Science Translational Medicine. 15
Pancreatic ductal adenocarcinoma (PDAC) is classified into two key subtypes, classical and basal, with basal PDAC predicting worse survival. Using in vitro drug assays, genetic manipulation experiments, and in vivo drug studies in human patient-deriv
Autor:
William C. Hahn, Jonathan E. Rosenberg, Anthony Letai, Rameen Beroukhim, David J. Kwiatkowski, Rosalyn M. Adam, Amy J. Schlauch, Rebecca Modiste, Anna C. Schinzel, Won Jun Kim, Bryan D. Kynnap, Mihir B. Doshi, Jennifer L. Guerriero, Andrew L. Hong
Copy number variation (CNV) of samples in TCGA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e9a8ed12e71126e7f256efe59322271
https://doi.org/10.1158/1541-7786.22512646.v1
https://doi.org/10.1158/1541-7786.22512646.v1
Autor:
William C. Hahn, Jonathan E. Rosenberg, Anthony Letai, Rameen Beroukhim, David J. Kwiatkowski, Rosalyn M. Adam, Amy J. Schlauch, Rebecca Modiste, Anna C. Schinzel, Won Jun Kim, Bryan D. Kynnap, Mihir B. Doshi, Jennifer L. Guerriero, Andrew L. Hong
DEDD and MCL1 overexpression are not necessary for initiation of tumorigenesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e738a76d52fbbf3534c9e7ef0c1e5af
https://doi.org/10.1158/1541-7786.22512655
https://doi.org/10.1158/1541-7786.22512655
Autor:
William C. Hahn, Jonathan E. Rosenberg, Anthony Letai, Rameen Beroukhim, David J. Kwiatkowski, Rosalyn M. Adam, Amy J. Schlauch, Rebecca Modiste, Anna C. Schinzel, Won Jun Kim, Bryan D. Kynnap, Mihir B. Doshi, Jennifer L. Guerriero, Andrew L. Hong
Focal amplification of chromosome 1q23.3 in patients with advanced primary or relapsed urothelial carcinomas is associated with poor survival. We interrogated chromosome 1q23.3 and the nearby focal amplicon 1q21.3, as both are associated with increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af212e75eaf64b3e7378fe26930013c5
https://doi.org/10.1158/1541-7786.c.6540298.v1
https://doi.org/10.1158/1541-7786.c.6540298.v1
Autor:
Andrew L. Hong, Yuen-Yi Tseng, Glenn S. Cowley, Oliver Jonas, Jaime H. Cheah, Bryan D. Kynnap, Mihir B. Doshi, Coyin Oh, Stephanie C. Meyer, Alanna J. Church, Shubhroz Gill, Craig M. Bielski, Paula Keskula, Alma Imamovic, Sara Howell, Gregory V. Kryukov, Paul A. Clemons, Aviad Tsherniak, Francisca Vazquez, Brian D. Crompton, Alykhan F. Shamji, Carlos Rodriguez-Galindo, Katherine A. Janeway, Charles W. M. Roberts, Kimberly Stegmaier, Paul van Hummelen, Michael J. Cima, Robert S. Langer, Levi A. Garraway, Stuart L. Schreiber, David E. Root, William C. Hahn, Jesse S. Boehm
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Identifying therapeutic targets in rare cancers is challenging due to the lack of relevant pre-clinical models. Here, the authors generate a cancer cell line from a paediatric patient with a rare undifferentiated sarcoma and through functional genomi
Externí odkaz:
https://doaj.org/article/a374f09a5d1640b381b40c1ebaec01db
Autor:
Karuna Mittal, Benjamin P. Lee, Garrett W. Cooper, Jenny Shim, Hunter C. Jonus, Won Jun Kim, Mihir Doshi, Diego Almanza, Bryan D. Kynnap, Amanda L. Christie, Xiaoping Yang, Glenn S. Cowley, Brittaney A. Leeper, Christopher L. Morton, Bhakti Dwivedi, Taylor Lawrence, Manali Rupji, Paula Keskula, Stephanie Meyer, Catherine M. Clinton, Manoj Bhasin, Brian D. Crompton, Yuen-Yi Tseng, Jesse S. Boehm, Keith L. Ligon, David E. Root, Andrew J. Murphy, David M. Weinstock, Prafulla C. Gokhale, Jennifer M. Spangle, Miguel N. Rivera, Elizabeth A. Mullen, Kimberly Stegmaier, Kelly C. Goldsmith, William C. Hahn, Andrew L. Hong
Wilms tumor (WT) is the most common renal malignancy of childhood. Despite improvements in the overall survival, relapse occurs in ~15% of patients with favorable histology WT (FHWT). Half of these patients will succumb to their disease. Identifying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::153f491f5631f0b90deb1ca15ecbd631
https://doi.org/10.1101/2022.02.23.481521
https://doi.org/10.1101/2022.02.23.481521
Autor:
Abeer Sayeed, Xiaoping Yang, Elizabeth Mullen, Gabriel J. Sandoval, Pratiti Bandopadhayay, Michelle Tillgren, Andrew L. Hong, William C. Hahn, Abigail Ward, Katherine Labella, Brian McSteen, Rameen Beroukhim, Adam Tracy, Mihir B. Doshi, Charles W. M. Roberts, Prafulla C. Gokhale, Won Jun Kim, Jesse S. Boehm, Mahmhoud Ghandi, Stuart L. Schreiber, David E. Root, Ji Li, Susan N. Chi, Jeremiah Wala, Ole Gjoerup, Cora Connor, Paul A. Clemons, Katherine A. Janeway, Thomas P. Howard, Alanna J. Church, Bryan D. Kynnap, David Sandak, Cigall Kadoch, Keith L. Ligon, Brian D. Crompton, Paula Keskula, Yuen-Yi Tseng, Rebecca Deasy, Guillaume Kugener, Barbara Van Hare, Catherine Clinton
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b44f99bc17d54121519cb0d6df6c5b3
https://doi.org/10.7554/elife.44161.051
https://doi.org/10.7554/elife.44161.051
Autor:
William C. Hahn, Bryan D. Kynnap, Anthony Letai, Rameen Beroukhim, Rosalyn M. Adam, Jonathan E. Rosenberg, Andrew L. Hong, Rebecca Modiste, Amy J. Schlauch, Mihir B. Doshi, David J. Kwiatkowski, Jennifer L. Guerriero, Anna C. Schinzel, Won Jun Kim
Publikováno v:
Mol Cancer Res
Focal amplification of chromosome 1q23.3 in patients with advanced primary or relapsed urothelial carcinomas is associated with poor survival. We interrogated chromosome 1q23.3 and the nearby focal amplicon 1q21.3, as both are associated with increas