Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Bryan D, Maliken"'
Autor:
Jessica T. Hochberg, Aalam Sohal, Priya Handa, Bryan D. Maliken, Take-Kyun Kim, Kai Wang, Eric Gochanour, Yu Li, J. Bart Rose, James E. Nelson, Keith D. Lindor, Nicholas F. LaRusso, Kris V. Kowdley
Publikováno v:
JHEP Reports, Vol 5, Iss 6, Pp 100729- (2023)
Background & Aims: Primary sclerosing cholangitis (PSC) is a chronic, progressive cholestatic liver disease that can lead to end-stage liver disease and cholangiocarcinoma. High-dose ursodeoxycholic acid (hd-UDCA, 28–30 mg/kg/day) was evaluated in
Externí odkaz:
https://doaj.org/article/5f55f7c82ccc4e648d616781d4396537
Autor:
Priya Handa, Bryan D. Maliken, James E. Nelson, Kelly A. Hennessey, L. Akhila Vemulakonda, Vicki Morgan-Stevenson, Barjinder K. Dhillon, Rohit Gupta, Matthew M. Yeh, Kris V. Kowdley
Publikováno v:
Annals of Hepatology, Vol 16, Iss 1, Pp 77-85 (2017)
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. We have previously shown that hepatic reticuloendothelial system (RES) iron deposition is associated with an advanced degree of nonalcoholic steatoh
Externí odkaz:
https://doaj.org/article/6bf710d62f12440ca5d8fc93b424908c
Autor:
Perwez Alam, Bereket Haile, Mohammed Arif, Raghav Pandey, Miso Rokvic, Michelle Nieman, Bryan D. Maliken, Arghya Paul, Yi‐Gang Wang, Sakthivel Sadayappan, Rafeeq P. H. Ahmed, Onur Kanisicak
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 15 (2019)
Background Myocardial infarction results in a large‐scale cardiomyocyte loss and heart failure due to subsequent pathological remodeling. Whereas zebrafish and neonatal mice have evident cardiomyocyte expansion following injury, adult mammalian car
Externí odkaz:
https://doaj.org/article/ff48335bd21441e6892468d41fbd5fe0
Autor:
Onur Kanisicak, Hadi Khalil, Malina J. Ivey, Jason Karch, Bryan D. Maliken, Robert N. Correll, Matthew J. Brody, Suh-Chin J. Lin, Bruce J. Aronow, Michelle D. Tallquist, Jeffery D. Molkentin
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
The origin and fate of myofibroblasts, the cells responsible for cardiac remodelling and fibrosis, is controversial. Here the authors show that cardiac myofibroblasts express periostin, derive exclusively from tissue-resident fibroblasts, are necessa
Externí odkaz:
https://doaj.org/article/2d97317374d240aba3646b2db0044a01
Autor:
Jason Karch, Tobias G Schips, Bryan D Maliken, Matthew J Brody, Michelle A Sargent, Onur Kanisicak, Jeffery D Molkentin
Publikováno v:
eLife, Vol 6 (2017)
Cells deficient in the pro-death Bcl-2 family members Bax and Bak are known to be resistant to apoptotic cell death, and previous we have shown that these two effectors are also needed for mitochondrial-dependent cellular necrosis (Karch et al., 2013
Externí odkaz:
https://doaj.org/article/4aac43792af04e3fb223c85bf1c58adf
Autor:
Bryan D. Maliken, William F. Avrin, James E. Nelson, Jody Mooney, Sankaran Kumar, Kris V. Kowdley
Publikováno v:
Annals of Hepatology, Vol 11, Iss 1, Pp 77-84 (2012)
Background. There is an ongoing clinical need for novel methods to measure hepatic iron content (HIC) noninvasively. Both magnetic resonance imaging (MRI) and superconducting quantum interference device (SQUID) methods have previously shown promise f
Externí odkaz:
https://doaj.org/article/17da53313a69457995de468557a8a407
Autor:
Jeffery D. Molkentin, Justin G. Boyer, Onur Kanisicak, Jason Karch, Yi Zheng, Hadi Khalil, Bryan D. Maliken, Xing Fu, Vikram Prasad
Publikováno v:
Circulation. 138:1012-1024
Background: Although c-Kit + adult progenitor cells were initially reported to produce new cardiomyocytes in the heart, recent genetic evidence suggests that such events are exceedingly rare. However, to determine if these rare events represent true
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75605d1719c21adfc10a9deb2f89564d
https://doi.org/10.1161/circulationaha.118.033703
https://doi.org/10.1161/circulationaha.118.033703
Autor:
Onur Kanisicak, Burns C. Blaxall, Justin G. Boyer, Ronald J. Vagnozzi, Jeffery D. Molkentin, Hadi Khalil, Bryan D. Maliken, Xing Fu, Iñigo Valiente-Alandi, Vikram Prasad, Michelle A. Sargent
Publikováno v:
The Journal of Clinical Investigation
The identity and function of the fibroblast, a highly prevalent cell type in the heart, have remained poorly defined. Recent faithful genetic lineage–tracing studies revealed that during development, the cardiac fibroblasts are derived from the epi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9263141f21c04673449a9c3a06b46199
http://europepmc.org/articles/PMC5957472
http://europepmc.org/articles/PMC5957472
Autor:
Perwez Alam, Bryan D. Maliken, Shannon M. Jones, Malina J. Ivey, Zhichao Wu, Yigang Wang, Onur Kanisicak
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 13104, p 13104 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 13104, p 13104 (2021)
The limited ability of mammalian adult cardiomyocytes to proliferate following an injury to the heart, such as myocardial infarction, is a major factor that results in adverse fibrotic and myocardial remodeling that ultimately leads to heart failure.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::320364857db035af13fdc0b58b74932a
https://doi.org/10.3390/ijms222313104
https://doi.org/10.3390/ijms222313104
Autor:
Bryan D. Maliken, Jeffery D. Molkentin
Publikováno v:
Circulation. 138:806-808
Whether the adult mammalian heart harbors cardiac stem cells for regeneration of cardiomyocytes is an important yet contentious topic in the field of cardiovascular regeneration. The putative myocyte stem cell populations recognized without specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21157b8e353d4d9565ce5dac83b2eb0b
https://doi.org/10.1161/circulationaha.118.035186
https://doi.org/10.1161/circulationaha.118.035186