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Akademický článek

Soluble Epoxide Hydrolase Hepatic Deficiency Ameliorates Alcohol-Associated Liver Disease

Autor: Aline Mello, Ming-Fo Hsu, Shinichiro Koike, Bryan Chu, Jeff Cheng, Jun Yang, Christophe Morisseau, Natalie J. Torok, Bruce D. Hammock, Fawaz G. Haj

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 3, Pp 815-830 (2021)

Background & Aims: Alcohol-associated liver disease (ALD) is a significant cause of liver-related morbidity and mortality worldwide and with limited therapies. Soluble epoxide hydrolase (sEH; Ephx2) is a largely cytosolic enzyme that is highly expres

Externí odkaz: https://doaj.org/article/010aa7f991b54df68a730bdad2aaaead

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Akademický článek

Amplified parallel antigen rapid test for point-of-care salivary detection of SARS-CoV-2 with improved sensitivity.

Autor: Tng, Danny Jian Hang^1,2,3 (AUTHOR) Danny@u.duke.nus.edu, Yin, Bryan Chu Yang² (AUTHOR), Cao, Jing^4,5 (AUTHOR), Ko, Kwan Ki Karrie⁶ (AUTHOR), Goh, Kenneth Choon Meng⁶ (AUTHOR), Chua, Delia Xue Wen⁴ (AUTHOR), Zhang, Yong⁴ (AUTHOR), Chua, Melvin Lee Kiang^3,7,8 (AUTHOR), Low, Jenny Guek Hong^1,2 (AUTHOR), Ooi, Eng Eong² (AUTHOR), Soo, Khee Chee^7,8 (AUTHOR) soo.khee.chee@singhealth.com.sg

Publikováno v: Microchimica Acta. Jan2022, Vol. 189 Issue 1, p1-12. 12p.

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Correction to: Amplified parallel antigen rapid test for point-of-care salivary detection of SARS-CoV-2 with improved sensitivity

Autor: Danny Jian Hang Tng, Bryan Chu Yang Yin, Jing Cao, Kwan Ki Karrie Ko, Kenneth Choon Meng Goh, Delia Xue Wen Chua, Yong Zhang, Melvin Lee Kiang Chua, Jenny Guek Hong Low, Eng Eong Ooi, Khee Chee Soo

Publikováno v: Microchimica Acta. 190

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ada500a43d5e5a286b2c0d1aa2fc6ad
https://doi.org/10.1007/s00604-022-05625-7

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Soluble Epoxide Hydrolase Hepatic Deficiency Ameliorates Alcohol-Associated Liver Disease

Autor: Bruce D. Hammock, A. F. S. Mello, Natalie J. Török, Fawaz G. Haj, Jun Yang, Ming-Fo Hsu, Bryan Chu, Christophe Morisseau, Jeff Cheng, Shinichiro Koike

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 3, Pp 815-830 (2021)
Cellular and molecular gastroenterology and hepatology, vol 11, iss 3
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Alcohol-associated liver disease (ALD) is a significant cause of liver-related morbidity and mortality worldwide and with limited therapies. Soluble epoxide hydrolase (sEH; Ephx2) is a largely cytosolic enzyme that is highly express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a37aec2ab2970ef64d585a65ffea8d3
http://www.sciencedirect.com/science/article/pii/S2352345X20301624

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Model-assisted deep learning of rare extreme events from partial observations

Autor: Anna Asch, Ethan J. Brady, Hugo Gallardo, John Hood, Bryan Chu, Mohammad Farazmand

To predict rare extreme events using deep neural networks, one encounters the so-called small data problem because even long-term observations often contain few extreme events. Here, we investigate a model-assisted framework where the training data i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c18a21403c645d245fc2e7227408ae
http://arxiv.org/abs/2111.04857

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Amplified parallel antigen rapid test for point-of-care salivary detection of SARS-CoV-2 with improved sensitivity

Autor: Tng, Danny Jian Hang, Yin, Bryan Chu Yang, Cao, Jing, Ko, Kwan Ki Karrie, Goh, Kenneth Choon Meng, Chua, Delia Xue Wen, Zhang, Yong, Chua, Melvin Lee Kiang, Low, Jenny Guek Hong, Ooi, Eng Eong, Soo, Khee Chee

Publikováno v: Mikrochimica Acta

In the ongoing COVID-19 pandemic, simple, rapid, point-of-care tests not requiring trained personnel for primary care testing are essential. Saliva-based antigen rapid tests (ARTs) can fulfil this need, but these tests require overnight-fasted sample

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a7417b644ce85c1c15d92e5d5ffff1
https://pubmed.ncbi.nlm.nih.gov/36609590

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Genetic deficiency or pharmacological inhibition of soluble epoxide hydrolase ameliorates high fat diet-induced pancreatic β-cell dysfunction and loss

Autor: Bryan Chu, Fawaz G. Haj, Ming-Fo Hsu, Peter J. Havel, Mark O. Huising, Christophe Morisseau, Bruce D. Hammock, Shinichiro Koike, Ahmed Bettaieb, Naoki Matsumoto

Publikováno v: Free Radic Biol Med

Pancreatic β-cells are crucial regulators of systemic glucose homeostasis, and their dysfunction and loss are central features in type 2 diabetes. Interventions that rectify β-cell dysfunction and loss are essential to combat this deadly malady. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3daea74f9ae1f66e04517256832dd1
https://escholarship.org/uc/item/03b8h68k

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Data-driven prediction of multistable systems from sparse measurements

Autor: Mohammad Farazmand, Bryan Chu

Publikováno v: Chaos: An Interdisciplinary Journal of Nonlinear Science. 31:063118

We develop a data-driven method, based on semi-supervised classification, to predict the asymptotic state of multistable systems when only sparse spatial measurements of the system are feasible. Our method predicts the asymptotic behavior of an obser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd6e52e9dd15650a7c8a98aa9dad8b02
https://doi.org/10.1063/5.0046203

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