Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Bryan C Tan"'
Autor:
Cheen Fei Chin, Dwight L.A. Galam, Liang Gao, Bryan C. Tan, Bernice H. Wong, Geok-Lin Chua, Randy Y.J. Loke, Yen Ching Lim, Markus R. Wenk, Miao-Shan Lim, Wei-Qiang Leow, George B.B. Goh, Federico Torta, David L. Silver
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 17 (2023)
The liver has a high demand for phosphatidylcholine (PC), particularly in overnutrition, where reduced phospholipid levels have been implicated in the development of nonalcoholic fatty liver disease (NAFLD). Whether other pathways exist in addition t
Externí odkaz:
https://doaj.org/article/65986795ef3e486290872e1e79aa32e1
Autor:
Randy Y.J. Loke, Cheen Fei Chin, Gao Liang, Bernice H. Wong, Dwight L.A. Galam, Bryan C. Tan, Geok-Lin Chua, Shintaro Minegishi, Norihiko Morisawa, Iulia Sidorov, Bram Heijs, Jens Titze, Markus R. Wenk, Federico Torta, David L. Silver
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 8, Pp 100416- (2023)
Acute kidney injury (AKI) is a global public health concern with high mortality and morbidity. In ischemic–reperfusion injury (IRI), a main cause of AKI, the brush border membrane of S3 proximal tubules (PT) is lost to the tubular lumen. How injure
Externí odkaz:
https://doaj.org/article/672d13e383c743709655a740077d87eb
Autor:
Diana Teh Chee Siang, Yen Ching Lim, Aung Maung Maung Kyaw, Khaing Nwe Win, Sook Yoong Chia, Ufuk Degirmenci, Xiang Hu, Bryan C. Tan, Arcinas Camille Esther Walet, Lei Sun, Dan Xu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Human antigen R (HuR) is an RNA binding protein that promotes mRNA stability. Here the authors show that HuR represses adipogenesis in white and brown adipose tissue by stabilizing Insig1 and other targets.
Externí odkaz:
https://doaj.org/article/d5a3ed7333c84e9d83c9d20cc549253a
Autor:
Patrick Tan, Bin Tean Teh, Jim R. Hughes, Gertrud Steger, Alexander Lezhava, David Lawrence Silver, Puay Hoon Tan, Kenneth Tou En Chang, Shang Li, Christopher Wai Sam Cheng, Iain Bee Huat Tan, Qiang Yu, Steven G. Rozen, Bryan C. Tan, Gary Loh, Jian Yuan Goh, James O. J. Davies, Swe Swe Myint, Chang Xu, Aditi Qamra, Tannistha Nandi, Joyce Suling Lin, Cassandra Zhengxuan He, Michelle Shu Wen Ng, Peiyong Guan, Ai Ping Lee-Lim, Jing Han Hong, Yue Ning Lam, Giovani Wijaya, Su Ting Tay, James Zhengzhong Qu, Yang Sun Chan, Manjie Xing, Dachuan Huang, Zhimei Li, Wen Fong Ooi, Joanna Koh, Kevin Junliang Lim, Jing Tan, Xiaosai Yao
Supplementary tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5c483f4796a51a74e512b695e9ee4ed
https://doi.org/10.1158/2159-8290.22531964.v1
https://doi.org/10.1158/2159-8290.22531964.v1
Autor:
Patrick Tan, Bin Tean Teh, Jim R. Hughes, Gertrud Steger, Alexander Lezhava, David Lawrence Silver, Puay Hoon Tan, Kenneth Tou En Chang, Shang Li, Christopher Wai Sam Cheng, Iain Bee Huat Tan, Qiang Yu, Steven G. Rozen, Bryan C. Tan, Gary Loh, Jian Yuan Goh, James O. J. Davies, Swe Swe Myint, Chang Xu, Aditi Qamra, Tannistha Nandi, Joyce Suling Lin, Cassandra Zhengxuan He, Michelle Shu Wen Ng, Peiyong Guan, Ai Ping Lee-Lim, Jing Han Hong, Yue Ning Lam, Giovani Wijaya, Su Ting Tay, James Zhengzhong Qu, Yang Sun Chan, Manjie Xing, Dachuan Huang, Zhimei Li, Wen Fong Ooi, Joanna Koh, Kevin Junliang Lim, Jing Tan, Xiaosai Yao
Supplementary methods. Supplementary Figures 1-9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3570da660e6b68b2d7d361cabd4ad3
https://doi.org/10.1158/2159-8290.22531967.v1
https://doi.org/10.1158/2159-8290.22531967.v1
Autor:
Menglan He, Alvin C. Y. Kuk, Mei Ding, Cheen Fei Chin, Dwight L.A. Galam, Jie Min Nah, Bryan C. Tan, Hui Li Yeo, Geok Lin Chua, Peter I. Benke, Markus R. Wenk, Lena Ho, Federico Torta, David L. Silver
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(40)
The lysosome is central to the degradation of proteins, carbohydrates, and lipids and their salvage back to the cytosol for reutilization. Lysosomal transporters for amino acids, sugars, and cholesterol have been identified, and the metabolic fates o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e8b394db013b78b902bbfceb0c73da
https://pubmed.ncbi.nlm.nih.gov/36161949
https://pubmed.ncbi.nlm.nih.gov/36161949
Autor:
Geok-Lin Chua, Bryan C. Tan, Randy Y. J. Loke, Menglan He, Cheen-Fei Chin, Bernice H. Wong, Alvin C. Y. Kuk, Mei Ding, Markus R. Wenk, Lan Guan, Federico Torta, David L. Silver
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Major Facilitator Superfamily Domain containing 2a (Mfsd2a) is a sodium-dependent lysophosphatidylcholine (LPC) transporter expressed at the blood–brain barrier that constitutes the main pathway by which the brain obtains omega-3 fatty acids, such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9135013a5992d6a112700ae4b817be17
https://doi.org/10.1073/pnas.2215290120
https://doi.org/10.1073/pnas.2215290120
Autor:
Bryan C. Tan, Sook Yoong Chia, Yen Ching Lim, Arcinas Camille Esther Walet, Ufuk Degirmenci, Diana Teh Chee Siang, Lei Sun, Khaing Nwe Win, Xiang Hu, Dan Xu, Aung Maung Maung Kyaw
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Human antigen R (HuR) is an essential regulator of RNA metabolism, but its function in metabolism remains unclear. This study identifies HuR as a major repressor during adipogenesis. Knockdown and overexpression of HuR in primary adipocyte culture en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f7d7c6252c793cbdddb8baf5976959e
http://link.springer.com/article/10.1038/s41467-019-14001-8
http://link.springer.com/article/10.1038/s41467-019-14001-8
Autor:
Amaury Cazenave-Gassiot, David L. Silver, Susan E. Quaggin, Maarja Andaloussi Mäe, Bàrbara Laviña, Elisa Vazquez-Liebanas, Bongnam Jung, Juat Chin Foo, Marie Jeansson, Annika Keller, Yvette Zarb, Michael Vanlandewijck, Markus R. Wenk, Liqun He, Khayrun Nahar, Chengua Gu, Bryan C. Tan, Eugene C. Butcher, Sofia Nordling, Christer Betsholtz, Xidan Li
Publikováno v:
Circulation Research
Rationale: Pericytes are capillary mural cells playing a role in stabilizing newly formed blood vessels during development and tissue repair. Loss of pericytes has been described in several brain disorders, and genetically induced pericyte deficiency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264129839b6a627479da7aa593cec962
https://doi.org/10.5167/uzh-196164
https://doi.org/10.5167/uzh-196164
Autor:
Lei Sun, Jolene S.Y. Tan, Yen Ching Lim, Vera J. Goh, David L. Silver, Sujoy Ghosh, Colin J.P. Seow, Bryan C. Tan, Wei-Yi Ong
Publikováno v:
Journal of Biological Chemistry. 290:25686-25699
Lipid droplets (LDs) are phylogenetically conserved cytoplasmic organelles that store neutral lipids within a phospholipid monolayer. LDs compartmentalize lipids and may help to prevent cellular damage caused by their excess or bioactive forms. FIT2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed2c6aeaa50b12b3ac2b1d24fa26784
https://doi.org/10.1074/jbc.m115.676700
https://doi.org/10.1074/jbc.m115.676700