Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Bryan C, Dickinson"'
Autor:
Minghui Di, Junjun Lv, Zhengyu Jing, Yijie Yang, Kunlun Yan, Jianguo Wu, Jianyang Ge, Simone Rauch, Bryan C. Dickinson, Tian Chi
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102190- (2024)
RNA base editors should ideally be free of immunogenicity, compact, efficient, and specific, which has not been achieved for C > U editing. Here we first describe a compact C > U editor entirely of human origin, created by fusing the human C > U edit
Externí odkaz:
https://doaj.org/article/d71c27d7d04f479ba03d8c405dd27ece
Autor:
Wei-Siang Liau, Qiongyi Zhao, Adekunle Bademosi, Rachel S. Gormal, Hao Gong, Paul R. Marshall, Ambika Periyakaruppiah, Sachithrani U. Madugalle, Esmi L. Zajaczkowski, Laura J. Leighton, Haobin Ren, Mason Musgrove, Joshua Davies, Simone Rauch, Chuan He, Bryan C. Dickinson, Xiang Li, Wei Wei, Frédéric A. Meunier, Sandra M. Fernández-Moya, Michael A. Kiebler, Balakumar Srinivasan, Sourav Banerjee, Michael Clark, Robert C. Spitale, Timothy W. Bredy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Long noncoding RNAs (lncRNAs) represent a multidimensional class of regulatory molecules that are involved in many aspects of brain function. Emerging evidence indicates that lncRNAs are localized to the synapse; however, a direct role for t
Externí odkaz:
https://doaj.org/article/988e064ab265447988a0b34da83e4592
Autor:
Yang Cao, Huachun Liu, Shannon S. Lu, Krysten A. Jones, Anitha P. Govind, Okunola Jeyifous, Christine Q. Simmons, Negar Tabatabaei, William N. Green, Jimmy. L. Holder, Soroush Tahmasebi, Alfred L. George, Bryan C. Dickinson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Technologies capable of programmable translation activation offer strategies to develop therapeutics for diseases caused by insufficient gene expression. Here, we present “translation-activating RNAs” (taRNAs), a bifunctional RNA-based m
Externí odkaz:
https://doaj.org/article/2f3bf8fe6f5a49a79837b57f3d09a867
Autor:
Taha Azad, Reza Rezaei, Ragunath Singaravelu, Adrian Pelin, Stephen Boulton, Julia Petryk, Kemal Alper Onsu, Nikolas T. Martin, Victoria Hoskin, Mina Ghahremani, Marie Marotel, Ricardo Marius, Xiaohong He, Mathieu J. F. Crupi, Huy-Dung Hoang, Abolfazl Nik-Akhtar, Mahsa Ahmadi, Nika Kooshki Zamani, Ashkan Golshani, Tommy Alain, Peter Greer, Michele Ardolino, Bryan C. Dickinson, Lee-Hwa Tai, Carolina S. Ilkow, John C. Bell
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The large coding potential of vaccinia virus (VV) vectors is a defining feature. However, limited regulatory switches are available to control viral replication as well as timing and dosing of transgene expression in order to facilitate safe
Externí odkaz:
https://doaj.org/article/ac9b0514948d4425b5c222c2feb15ba2
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113135- (2023)
Summary: Extracellular signal-regulated kinases (ERK1/2) are key effector proteins of the mitogen-activated protein kinase pathway, choreographing essential processes of cellular physiology. Here, we discover that ERK1/2 are subject to S-acylation, a
Externí odkaz:
https://doaj.org/article/4ed335a66de445fa9add634cff2a6477
Autor:
Alexander Krohannon, Mansi Srivastava, Simone Rauch, Rajneesh Srivastava, Bryan C. Dickinson, Sarath Chandra Janga
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-10 (2022)
Abstract Background Recent discovery of the gene editing system - CRISPR (Clustered Regularly Interspersed Short Palindromic Repeats) associated proteins (Cas), has resulted in its widespread use for improved understanding of a variety of biological
Externí odkaz:
https://doaj.org/article/481167256dcb47cc85b673944de6d728
Publikováno v:
ACS Central Science, Vol 7, Iss 9, Pp 1581-1590 (2021)
Externí odkaz:
https://doaj.org/article/42842d5140c946a3a8499bd8ce3d4de5
Autor:
Nikolas T. Martin, Mathieu J. F. Crupi, Zaid Taha, Joanna Poutou, Jack T. Whelan, Sydney Vallati, Julia Petryk, Ricardo Marius, Bradley Austin, Taha Azad, Mason Boulanger, Tamara Burgess, Ilson Sanders, Camille Victoor, Bryan C. Dickinson, Jean-Simon Diallo, Carolina S. Ilkow, John C. Bell
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 709 (2023)
The approval of different cytokines as anti-neoplastic agents has been challenged by dose-limiting toxicities. Although reducing dose levels affords improved tolerability, efficacy is precluded at these suboptimal doses. Strategies combining cytokine
Externí odkaz:
https://doaj.org/article/390661383464430eafc22cdd62a9b18f
Autor:
Jerzy Osipiuk, Saara-Anne Azizi, Steve Dvorkin, Michael Endres, Robert Jedrzejczak, Krysten A. Jones, Soowon Kang, Rahul S. Kathayat, Youngchang Kim, Vladislav G. Lisnyak, Samantha L. Maki, Vlad Nicolaescu, Cooper A. Taylor, Christine Tesar, Yu-An Zhang, Zhiyao Zhou, Glenn Randall, Karolina Michalska, Scott A. Snyder, Bryan C. Dickinson, Andrzej Joachimiak
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
The SARS-CoV-2 papain-like protease (PLpro) is of interest as an antiviral drug target. Here, the authors synthesize and characterise naphthalene-based inhibitors for PLpro and present the crystal structures of PLpro in its apo state and with the bou
Externí odkaz:
https://doaj.org/article/78bca1985cf441b2b78df027d7429e6e
Publikováno v:
ACS Central Science, Vol 6, Iss 11, Pp 1987-1996 (2020)
Externí odkaz:
https://doaj.org/article/aa5d8bb7a6f4484e9f92767fffbba69b