Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Bryan Belikoff"'
Autor:
Delphine L Chen, Howard J Huang, Derek E Byers, Adrian Shifren, Bryan Belikoff, Jacquelyn T Engle, Elizabeth Arentson, Debra Kemp, Sharon Phillips, David E Scherrer, Hideji Fujiwara, Katherine J Spayd, Frank J Brooks, Richard A Pierce, Mario Castro, Warren Isakow
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0191783 (2018)
BACKGROUND:Anti-inflammatory drug development efforts for lung disease have been hampered in part by the lack of noninvasive inflammation biomarkers and the limited ability of animal models to predict efficacy in humans. We used 18F-fluorodeoxyglucos
Externí odkaz:
https://doaj.org/article/eab584034270471c847af99e2a775ed8
Autor:
Bryan Belikoff, Michail V. Sitkovsky, Dmitriy Lukashev, Akio Ohta, Robert G. Abbott, Stephen M. Hatfield
Publikováno v:
Cancer Immunology Research. 2:598-605
Hypoxia-driven, A2A adenosine receptor (A2AR)–mediated (hypoxia–A2-adenosinergic), T-cell–autonomous immunosuppression was first recognized as critical and nonredundant in protecting normal tissues from inflammatory damage and autoimmunity. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20fd35b9bbe4fb0aacc879ba3ea61dbf
https://doi.org/10.1158/2326-6066.cir-14-0075
https://doi.org/10.1158/2326-6066.cir-14-0075
Autor:
Stephen M. Hatfield, Peter Georgiev, Bryan Belikoff, Michail V. Sitkovsky, Akio Ohta, Dmitriy Lukashev
Publikováno v:
European Journal of Immunology. 43:655-666
Hypoxia-adenosinergic suppression and redirection of the immune response has been implicated in the regulation of antipathogen and antitumor immunity, with hypoxia-inducible factor 1α (HIF-1α) playing a major role. In this study, we investigated th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f10bfded2c0c556973eff04be809cb1f
https://doi.org/10.1002/eji.201242765
https://doi.org/10.1002/eji.201242765
Publikováno v:
The Journal of Immunology. 189:3707-3713
Asthma is a chronic condition with high morbidity and healthcare costs, and cockroach allergens are an established cause of urban pediatric asthma. A better understanding of cell types involved in promoting lung inflammation could provide new targets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de13399803ad66d43a8ce018b378a3b3
https://doi.org/10.4049/jimmunol.1201207
https://doi.org/10.4049/jimmunol.1201207
Publikováno v:
Shock. 37:56-62
Sepsis is one of the leading causes of death in hospitals worldwide. Even with optimal therapy, severe sepsis results in 50% mortality, indicating variability in the response of individuals towards treatment. We hypothesize that the presence of preex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f4d2159492db249796d0854f577f7b
https://doi.org/10.1097/shk.0b013e3182356f3e
https://doi.org/10.1097/shk.0b013e3182356f3e
Autor:
Dmitriy Lukashev, Jeffrey L. Kutok, Shalini Sethumadhavan, Phaethon Philbrook, Michail V. Sitkovsky, Bryan Belikoff, Barry L. Karger, Ryan Cannici, Jorgen Kjaergaard, Robert K. Abbott, Eckhard R. Podack, Taylor H. Schreiber, Stephen M. Hatfield, Akio Ohta, Molly Thayer, Kami Ko, Scott J. Rodig, Edwin K. Jackson
Publikováno v:
Science Translational Medicine. 7
Antitumor T cells either avoid or are inhibited in hypoxic and extracellular adenosine-rich tumor microenvironments (TMEs) by A2A adenosine receptors. This may limit further advances in cancer immunotherapy. There is a need for readily available and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200e6276d18578281565bb4877f3b34b
https://doi.org/10.1126/scitranslmed.aaa1260
https://doi.org/10.1126/scitranslmed.aaa1260
Publikováno v:
Academic Emergency Medicine. 13:707-714
OBJECTIVES To investigate the effect of hyperbaric oxygen (HBO2) on acetaminophen (APAP)-induced hepatotoxicity. The authors further evaluated the effects of APAP poisoning and HBO2 on the expression and function of hypoxia-inducible factor 1-alpha (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8ca58bb1794b9fd1c216c5bfe8fc155
https://doi.org/10.1197/j.aem.2006.01.029
https://doi.org/10.1197/j.aem.2006.01.029
Autor:
Peter Carmeliet, William C. Aird, Natalya Bodyak, Kiichiro Yano, Peter M. Kang, S. Ananth Karumanchi, Joseph P. Mizgerd, Bryan Belikoff, Hitomi Okada, Janet Mullington, Patricia C. Liaw, Benjamin T. Simms, Shu-Ching Shih, Jon A. Buras, Lisa J. Toltl
Publikováno v:
The Journal of Experimental Medicine
Sepsis, the systemic inflammatory response to infection, is a leading cause of morbidity and mortality. The mechanisms of sepsis pathophysiology remain obscure but are likely to involve a complex interplay between mediators of the inflammatory and co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c7704eedca6612da17eda1e0b41180f
https://doi.org/10.1084/jem.20060375
https://doi.org/10.1084/jem.20060375
Autor:
Phaethon Philbrook, Scott J. Rodig, Bryan Belikoff, Dmitriy Lukashev, Jin Ren, Dai Shujia, Shalini Sethumadhavan, Eckhard R. Podack, Michail V. Sitkovsky, Taylor H. Schreiber, Robert K. Abbott, Akio Ohta, Edwin K. Jackson, Jorgen Kjaergaard, Molly Thayer, Jeffrey L. Kutok, Stephen M. Hatfield, Barry L. Karger
Publikováno v:
Journal of molecular medicine (Berlin, Germany). 92(12)
Intratumoral hypoxia and hypoxia inducible factor-1α (HIF-1-α)-dependent CD39/CD73 ectoenzymes may govern the accumulation of tumor-protecting extracellular adenosine and signaling through A2A adenosine receptors (A2AR) in tumor microenvironments (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a697989c410c0ab0ad1b8a759a73abed
https://pubmed.ncbi.nlm.nih.gov/25120128
https://pubmed.ncbi.nlm.nih.gov/25120128
Strategies are needed to reverse the immune cell hyporesponsiveness and prevent bacterial overgrowth associated with high mortality rates in septic patients. Adenosine signaling may be mediating immunosuppressive signals within the inflammatory micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf411cd4e498c1256d15e4c449d148c
https://europepmc.org/articles/PMC3693562/
https://europepmc.org/articles/PMC3693562/
