Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Bryan Au"'
Autor:
Diane R. Campbell, Ann K. Sakai, Stephen G. Weller, Theresa M. Culley, Amy K. Dunbar‐Wallis, Allen M. Andres, Tiffany G. Wong, Tam Dang, Bryan Au, Mickey Ku, Andrea R. Marcantonio, Paul J. Ngo, Andrew A. Nguyen, My Hanh Tran, Quoc‐Phong Tran
Publikováno v:
American journal of botany, vol 109, iss 11
PremiseEvolution of separate sexes from hermaphroditism often proceeds through gynodioecy, but genetic constraints on this process are poorly understood. Genetic (co-)variances and between-sex genetic correlations were used to predict evolutionary re
Autor:
Mona Abaoui, Axel Schambach, Michael Rothe, Aneal Khan, Jeffrey A. Medin, John S. Klassen, Ju Huang, Jack W. Rip, Michael West, Armand Keating, Lucia Lopez-Vasquez, Ronan Foley, Murtaza S. Nagree, Sandra Sirrs, Christiane Auray-Blais, Dwayne L. Barber, Michel Boutin, Bryan Au, Nicole L. Prokopishyn, Patricia V. Turner, Shaalee Dworski, C. Anthony Rupar
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 5, Iss C, Pp 241-258 (2017)
Fabry disease is a rare lysosomal storage disorder (LSD). We designed multiple recombinant lentivirus vectors (LVs) and tested their ability to engineer expression of human α-galactosidase A (α-gal A) in transduced Fabry patient CD34+ hematopoietic
Publikováno v:
CJEM. 20:471-475
Recent technological advances allow for instantaneous high quality video and audio recordings with the touch of a button. In Canada, patient privacy is highly regulated by provincial legislation, although patients themselves have little in the way of
Autor:
Caren Furlonger, Alexandra Berger, Jessa Trentadue, Joshua M. Moreau, Christopher J. Paige, Jeffrey A. Medin, Makoto Yoshimitsu, Bryan Au, Shaalee Dworski
Publikováno v:
Haematologica. 100:e162-e165
Acid ceramidase (ACDase) is ubiquitous and catalyzes the degradation of ceramide. ACDase and ceramides have been implicated in many disorders, including cancer, obesity, diabetes, inflammation, and neurodegenerative diseases.[1][1]–[3][2] Deficienc
Autor:
Beth Binnington, Christiane Auray-Blais, Mustafa Kamani, Tonny C Huang, Jeffrey A. Medin, Anton Novak, Michel Boutin, Philippe Provençal, Bryan Au, Clifford A. Lingwood, Natalia Pacienza, Xin Fan
Publikováno v:
Future Science OA
Aim: Fabry disease is caused by α-galactosidase A deficiency leading to accumulation of globotriaosylceramide (Gb3) in tissues. Clinical manifestations do not appear to correlate with total Gb3 levels. Studies examining tissue distribution of specif
Autor:
Michel Boutin, Philippe Provençal, Bryan Au, Christiane Auray-Blais, Shaalee Dworski, Jeffrey A. Medin
Publikováno v:
Bioanalysis. 8(17)
Aim: Fabry disease is a lysosomal storage disorder leading to glycosphingolipid accumulation in different organs, tissues and biological fluids. The development of a Fabry disease gene therapy trial is underway in Canada. A tool to determine the dist
Autor:
Stéphane Carpentier, Virginie Garcia, Bryan Au, Josefina Casas, Thierry Levade, Razqallah Hakem, James C.M. Wang, Gemma Fabriàs, Kevin N. Kirouac, Calogera M. Simonaro, Patricia V. Turner, Mathilde J. Exertier, Zi Jian Xiong, Samah El‐Ghamrasni, Jeffrey A. Medin, Abdulfatah Alayoubi, Edward H. Schuchman, Gilbert G. Privé, Shaalee Dworski
Publikováno v:
EMBO Molecular Medicine
Farber disease (FD) is a severe inherited disorder of lipid metabolism characterized by deficient lysosomal acid ceramidase (ACDase) activity, resulting in ceramide accumulation. Ceramide and metabolites have roles in cell apoptosis and proliferation
Autor:
Michael Rothe, Andrea Arruda, Axel Schambach, Yuanfeng Liu, Jeffrey A. Medin, Ju Huang, Bryan Au, Dwayne L. Barber, Mark D. Minden, Christopher J. Paige
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Interleukin-12 (IL-12) is a potent cytokine that may be harnessed to treat cancer. To date, nearly 100 IL-12-based clinical trials have been initiated worldwide. Yet systemic administration of IL-12 is toxic. Different strategies are being developed
Autor:
Makoto Yoshimitsu, Jeffrey A. Medin, Nobuo Mizue, Toshihiro Takenaka, Natalia Pacienza, Xin Fan, James C.M. Wang, Bryan Au
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Fabry disease is a lysosomal storage disorder caused by a deficiency of a-galactosidase A (a-gal A) activity that results in progressive globotriaosylceramide (Gb(3)) deposition. We created a fully congenic nonobese diabetic (NOD)/severe combined imm
Autor:
Junhui Wang, Daniel H. Fowler, Orlay Lopez-Perez, Ronan Foley, Jeffrey A. Medin, Bryan Au, Natalia Pacienza, Anton Neschadim, Sean Devine, C-J Lee, Matthew Scaife, Elizabeth Scheid
Publikováno v:
Gene Therapy. 20:24-34
Cell-fate control gene therapy (CFCGT)-based strategies can augment existing gene therapy and cell transplantation approaches by providing a safety element in the event of deleterious outcomes. Previously, we described a novel enzyme/prodrug combinat