Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Bryan, Zeitler"'
Autor:
Yasaman Ataei, Larry Park, D. James Surmeier, B. Joseph Vu, Seung Kwak, Richard T. Surosky, Anand Narayanan, David A. Shivak, Josee Laganiere, Christer Halldin, Andrea Varrone, Matthew C. Mendel, Karsten Tillack, Lei Zhang, Bryan Zeitler, Dmitry Guschin, Lexi Kopan, Sarah J. Hinkley, Kimberly Marlen, Jocelynn R. Pearl, Qi Yu, Taneli Heikkinen, Annette Gärtner, Yalda Sedaghat, Christina Thiede, Miklós Tóth, Jennifer M. Cherone, David Paschon, Jyothisri Kondapalli, Andrea E. Kudwa, Ladislav Mrzljak, Rainier Amora, Kimmo Lehtimäki, Edward J. Rebar, Lenke Tari, Ignacio Munoz-Sanjuan, Jeffrey C. Miller, Sylvie Ramboz, Marie Svedberg, Steven Froelich, Irina Ankoudinova, Philip D. Gregory, Stephen Lam, Michelle Day, Jonathan Bard, Hoang Oanh B. Nguyen, Fyodor D. Urnov, Davis Li, Jenny Haggkvist, H. Steve Zhang, Guijuan Qiao
Publikováno v:
Nature Medicine. 25:1131-1142
Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin gene (HTT), which codes for the pathologic mutant HTT (mHTT) protein. Since normal HTT is thought to be importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d19307c1ae395108f0cf1b74fb590fb6
https://doi.org/10.1038/s41591-019-0478-3
https://doi.org/10.1038/s41591-019-0478-3
Persistent repression of tau in the brain using engineered zinc finger protein transcription factors
Autor:
Susanne Wegmann, Bradley T. Hyman, Annemarie Ledeboer, Jeffrey C. Miller, Marta Perez-Rando, Kimberly Marlen, Richard T. Surosky, Bryan Zeitler, Caitlin Commins, Alison Chase, Michael C. Holmes, Sarah J. Hinkley, Alicia Goodwin, Riley N. Bannon, Lei Zhang, Brigit E. Riley, Hoang-Oanh B. Nguyen, Sarah L. DeVos, Edward J. Rebar, Ashley B. Robbins, Stephen Lam, Rainier Amora, Irina Ankoudinova, Qi Yu, Amy M. Pooler, Hung Tran, Nicholas A. Scarlott, Bianca T. Corjuc, Danny MacKenzie, Fyodor D. Urnov, H. Steve Zhang, Lisa Diez, Rachel E. Bennett
Publikováno v:
Science advances 7(12), eabe1611-(2021). doi:10.1126/sciadv.abe1611
Science Advances
Science Advances
Zinc finger proteins targeted to MAPT safely repress tau mRNA in the adult mouse brain and protect against Aβ toxicity.
Neuronal tau reduction confers resilience against β-amyloid and tau-related neurotoxicity in vitro and in vivo. Here, we in
Neuronal tau reduction confers resilience against β-amyloid and tau-related neurotoxicity in vitro and in vivo. Here, we in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1e249560ae8a0539e415f467dba78e
Autor:
John Kemeny, Bryan Zeitler
Publikováno v:
2001 Annual Conference Proceedings.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66db1824c24b1b4654224ad97b8a76df
https://doi.org/10.18260/1-2--9625
https://doi.org/10.18260/1-2--9625
Autor:
Tatiana Flisikowska, Irmgard S Thorey, Sonja Offner, Francesca Ros, Valeria Lifke, Bryan Zeitler, Oswald Rottmann, Anna Vincent, Lei Zhang, Shirin Jenkins, Helmut Niersbach, Alexander J Kind, Philip D Gregory, Angelika E Schnieke, Josef Platzer
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21045 (2011)
Rabbits are widely used in biomedical research, yet techniques for their precise genetic modification are lacking. We demonstrate that zinc finger nucleases (ZFNs) introduced into fertilized oocytes can inactivate a chosen gene by mutagenesis and als
Externí odkaz:
https://doaj.org/article/28865b2f7cbb4665ba7b4622b6f2e4fd
Autor:
Bryan, Zeitler, Steven, Froelich, Kimberly, Marlen, David A, Shivak, Qi, Yu, Davis, Li, Jocelynn R, Pearl, Jeffrey C, Miller, Lei, Zhang, David E, Paschon, Sarah J, Hinkley, Irina, Ankoudinova, Stephen, Lam, Dmitry, Guschin, Lexi, Kopan, Jennifer M, Cherone, Hoang-Oanh B, Nguyen, Guijuan, Qiao, Yasaman, Ataei, Matthew C, Mendel, Rainier, Amora, Richard, Surosky, Josee, Laganiere, B Joseph, Vu, Anand, Narayanan, Yalda, Sedaghat, Karsten, Tillack, Christina, Thiede, Annette, Gärtner, Seung, Kwak, Jonathan, Bard, Ladislav, Mrzljak, Larry, Park, Taneli, Heikkinen, Kimmo K, Lehtimäki, Marie M, Svedberg, Jenny, Häggkvist, Lenke, Tari, Miklós, Tóth, Andrea, Varrone, Christer, Halldin, Andrea E, Kudwa, Sylvie, Ramboz, Michelle, Day, Jyothisri, Kondapalli, D James, Surmeier, Fyodor D, Urnov, Philip D, Gregory, Edward J, Rebar, Ignacio, Muñoz-Sanjuán, H Steve, Zhang
Publikováno v:
Nature medicine. 25(7)
Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin gene (HTT), which codes for the pathologic mutant HTT (mHTT) protein. Since normal HTT is thought to be important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4d3620bad8fe21aa64bd37ef53578561
https://pubmed.ncbi.nlm.nih.gov/31263285
https://pubmed.ncbi.nlm.nih.gov/31263285
Autor:
Jocelynn R. Pearl, Philip D. Gregory, Joseph F. Petolino, Tonya L. Strange, Bryan Zeitler, Fyodor D. Urnov, Steve Evans, Ryan C. Blue, David Huizinga, Jianquan Li
Publikováno v:
Plant Biotechnology Journal. 11:671-680
Targeted gene regulation via designed transcription factors has great potential for precise phenotypic modification and acceleration of novel crop trait development. To this end, designed transcriptional activators have been constructed by fusing tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5557e255028eae79b458c18c3dbb25ab
https://doi.org/10.1111/pbi.12057
https://doi.org/10.1111/pbi.12057
Autor:
Philip D. Gregory, Jocelynn R. Pearl, Edward J. Rebar, Lei Zhang, Manuel Llinás, David A. Fidock, Marcus C. S. Lee, Fyodor D. Urnov, Judith Straimer, Andrew H. Lee, April E. Williams, Bryan Zeitler
Publikováno v:
Nature Methods. 9:993-998
Malaria afflicts over 200 million people worldwide and its most lethal etiologic agent, Plasmodium falciparum, is evolving to resist even the latest-generation therapeutics. Efficient tools for genome-directed investigations of P. falciparum pathogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943e45534d08a65c009f42d9bfe5a35b
https://doi.org/10.1038/nmeth.2143
https://doi.org/10.1038/nmeth.2143
Autor:
Yolanda Santiago, Sarah J. Hinkley, John P. Cassady, Qing Gao, Samira Kiani, Lei Zhang, Rudolf Jaenisch, Edward J. Rebar, Dirk Hockemeyer, Bryan Zeitler, Haoyi Wang, Jeffrey C. Miller, Jennifer M. Cherone, Fyodor D. Urnov, Christine S. Lai, Philip D. Gregory, Xiangdong Meng, Gregory J. Cost
Publikováno v:
Nature biotechnology
Targeted genetic engineering of human pluripotent cells is a prerequisite for exploiting their full potential. Such genetic manipulations can be achieved using site-specific nucleases. Here we engineered transcription activator-like effector nuclease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2029363c199e97563f28bbf1ee8e846d
https://doi.org/10.1038/nbt.1927
https://doi.org/10.1038/nbt.1927
Autor:
Yannick Doyon, Aaron T. Cheng, Philip D. Gregory, Edward J. Rebar, Jeffrey B. Doyon, Thuy D Vo, Jackie Cheng, Bryan Zeitler, David G. Drubin, David Paschon, Fyodor D. Urnov, Lei Zhang, Jeffrey C. Miller, Jennifer M. Cherone, Andrew H. Lee, Yolanda Santiago
Publikováno v:
Nature Cell Biology. 13:331-337
Clathrin-mediated endocytosis (CME) is the best-studied pathway by which cells selectively internalize molecules from the plasma membrane and surrounding environment. Previous live-cell imaging studies using ectopically overexpressed fluorescent fusi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21f3f0820e07fb2e424bb5a34634b9a
https://doi.org/10.1038/ncb2175
https://doi.org/10.1038/ncb2175
Autor:
Russell Dekelver, Caroline Beard, Jeffrey C. Miller, Maisam Mitalipova, Frank Soldner, Bryan Zeitler, Ranier Amora, Lei Zhang, Xiangdong Meng, Elizabeth A. Boydston, Rudolf Jaenisch, George E. Katibah, Philip D. Gregory, Fyodor D. Urnov, Edward J. Rebar, Dirk Hockemeyer, Qing Gao
Publikováno v:
Nature Biotechnology. 27:851-857
Human embryonic stem cells and induced pluripotent stem cells (hESCs and hiPSCs) are powerful tools for biomedical research. Realizing the full potential of these cells requires efficient genetic modification. However, techniques to generate cell typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceee8b083c1aa9b8092465373b91fe82
https://doi.org/10.1038/nbt.1562
https://doi.org/10.1038/nbt.1562