Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Bryan, Serrels"'
Autor:
Adam Byron, Billie G. C. Griffith, Ana Herrero, Alexander E. P. Loftus, Emma S. Koeleman, Linda Kogerman, John C. Dawson, Niamh McGivern, Jayne Culley, Graeme R. Grimes, Bryan Serrels, Alex von Kriegsheim, Valerie G. Brunton, Margaret C. Frame
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Cell adhesion proteins have been described at sites away from the cell surface, including in the nucleus. Here, the authors report the scale of nuclear localisation of adhesion proteins, establishing a nucleo-adhesome and showing that nuclear adhesio
Externí odkaz:
https://doaj.org/article/83349dab846e4f55a388ec199c877673
Autor:
Billie G. C. Griffith, Rosanna Upstill-Goddard, Holly Brunton, Graeme R. Grimes, Andrew V. Biankin, Bryan Serrels, Adam Byron, Margaret C. Frame
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Focal adhesion kinase (FAK) localizes to focal adhesions and is overexpressed in many cancers. FAK can also translocate to the nucleus, where it binds to, and regulates, several transcription factors, including MBD2, p53 and IL-33, to contro
Externí odkaz:
https://doaj.org/article/164998aec79f4674b257ec55ae3e2b20
Autor:
Adam Byron, Stephan Bernhardt, Bérèngere Ouine, Aurélie Cartier, Kenneth G. Macleod, Neil O. Carragher, Vonick Sibut, Ulrike Korf, Bryan Serrels, Leanne de Koning
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Reverse-phase protein array (RPPA) technology uses panels of high-specificity antibodies to measure proteins and protein post-translational modifications in cells and tissues. The approach offers sensitive and precise quantification of large
Externí odkaz:
https://doaj.org/article/07e3b471ccaf448185223b213fb7f35a
Autor:
Margaret C. Frame, Neil O. Carragher, Daniel Lietha, Alex von Kriegsheim, Amaya García-Muñoz, Ashraff Makda, Morwenna T. Muir, Adam Byron, Bryan Serrels, John C. Dawson
Quantification of YAP localization in esophageal cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aeaefc45ec2edeaa334529edbfcd1f4
https://doi.org/10.1158/1535-7163.22506288.v1
https://doi.org/10.1158/1535-7163.22506288.v1
Autor:
Margaret C. Frame, Neil O. Carragher, Daniel Lietha, Alex von Kriegsheim, Amaya García-Muñoz, Ashraff Makda, Morwenna T. Muir, Adam Byron, Bryan Serrels, John C. Dawson
We mutated the focal adhesion kinase (FAK) catalytic domain to inhibit binding of the chaperone Cdc37 and ATP, mimicking the actions of a FAK kinase inhibitor. We reexpressed mutant and wild-type FAK in squamous cell carcinoma (SCC) cells from which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d91c39eb635f3918725cf611b30b136
https://doi.org/10.1158/1535-7163.c.6538347
https://doi.org/10.1158/1535-7163.c.6538347
Autor:
Margaret C. Frame, Neil O. Carragher, Daniel Lietha, Alex von Kriegsheim, Amaya García-Muñoz, Ashraff Makda, Morwenna T. Muir, Adam Byron, Bryan Serrels, John C. Dawson
FAK kinase-dependent dysregulation of specific FAK-binding proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063d73f411d884de8a2ef1930a7ef1fe
https://doi.org/10.1158/1535-7163.22506285.v1
https://doi.org/10.1158/1535-7163.22506285.v1
Autor:
Margaret C. Frame, Neil O. Carragher, Daniel Lietha, Alex von Kriegsheim, Amaya García-Muñoz, Ashraff Makda, Morwenna T. Muir, Adam Byron, Bryan Serrels, John C. Dawson
Supplementary Materials and Methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0d18d38261bafa3b16c2f1f48a7fb2b
https://doi.org/10.1158/1535-7163.22506279
https://doi.org/10.1158/1535-7163.22506279
Autor:
Kairbaan M. Hodivala-Dilke, Thomas Iskratsch, Maddy Parsons, Bryan Serrels, Bernardo Tavora, Silvia Batista, Annika N. Alexopoulou, Vassiliki Kostourou, Delphine M. Lees, Isabelle Fernandez, Paraskivi Natalia Georgiou, Louise E. Reynolds, Edward P. Carter, Jesus Gomez-Escudero, Natalia Bodrug, Ana-Rita Pedrosa
Supplementary Figure 1 and 2. Generation and Characterisation of ECCre+;FAKY397F/Y397F and ECCre+;FAKY861F/Y861F mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5282133926484d2f37715e73d3989246
https://doi.org/10.1158/0008-5472.22422237.v1
https://doi.org/10.1158/0008-5472.22422237.v1
Autor:
Kairbaan M. Hodivala-Dilke, Thomas Iskratsch, Maddy Parsons, Bryan Serrels, Bernardo Tavora, Silvia Batista, Annika N. Alexopoulou, Vassiliki Kostourou, Delphine M. Lees, Isabelle Fernandez, Paraskivi Natalia Georgiou, Louise E. Reynolds, Edward P. Carter, Jesus Gomez-Escudero, Natalia Bodrug, Ana-Rita Pedrosa
Supplementary Figure 6. Knocking down Ang-2 in B16F0s cells ablates angiogenic response in ECCre+;FAKY861F/Y861F mice in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ed9c4100bd25c2f70043fe68231339
https://doi.org/10.1158/0008-5472.22422225.v1
https://doi.org/10.1158/0008-5472.22422225.v1
Autor:
Kairbaan M. Hodivala-Dilke, Thomas Iskratsch, Maddy Parsons, Bryan Serrels, Bernardo Tavora, Silvia Batista, Annika N. Alexopoulou, Vassiliki Kostourou, Delphine M. Lees, Isabelle Fernandez, Paraskivi Natalia Georgiou, Louise E. Reynolds, Edward P. Carter, Jesus Gomez-Escudero, Natalia Bodrug, Ana-Rita Pedrosa
Expression of focal adhesion kinase (FAK) in endothelial cells (EC) is essential for angiogenesis, but how FAK phosphorylation at tyrosine-(Y)397 and Y861 regulate tumor angiogenesis in vivo is unknown. Here, we show that tumor growth and angiogenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1eee9a002e76a2569618268b1a0af530
https://doi.org/10.1158/0008-5472.c.6511158.v1
https://doi.org/10.1158/0008-5472.c.6511158.v1