TREM2 variants that cause early dementia and increase Alzheimer's disease risk affect gene splicing.

Autor: Kiianitsa, Kostantin, Lukes, Maria E, Hayes, Brian J, Brutman, Julianna N, Valdmanis, Paul N, Bird, Thomas D, Raskind, Wendy H, Korvatska, Olena

Publikováno v: Brain: A Journal of Neurology; Jul2024, Vol. 147 Issue 7, p2368-2383, 16p

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TREM2 variants that cause early dementia and increase Alzheimer's disease risk affect gene splicing.

Autor: Kiianitsa K; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA., Lukes ME; Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA., Hayes BJ; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Brutman JN; Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA., Valdmanis PN; Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA., Bird TD; Department of Neurology, University of Washington, Seattle, WA 98195, USA.; Geriatric Research, Education and Clinical Center (GRECC), VA Puget Sound Medical Center, Seattle, WA 98108, USA., Raskind WH; Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA.; Mental Illness Research, Education and Clinical Center (MIRECC), VA Puget Sound Medical Center, Seattle, WA 98108, USA., Korvatska O; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA.

Publikováno v: Brain : a journal of neurology [Brain] 2024 Jul 05; Vol. 147 (7), pp. 2368-2383.