Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Bruns A. Watts"'
Publikováno v:
Am J Physiol Renal Physiol
Sepsis is the leading cause of acute kidney injury in critically ill patients. Tumor necrosis factor-α (TNF-α) has been implicated in the pathogenesis of septic kidney injury; however, the sites and mechanisms of renal TNF-α production during seps
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f44085f9fc0c1a2e29a17f52f0f5cb8
https://europepmc.org/articles/PMC7468828/
https://europepmc.org/articles/PMC7468828/
Publikováno v:
American Journal of Physiology-Renal Physiology. 315:F711-F725
Metabolic acidosis is the most common acid-base disorder in septic patients and is associated with increased mortality. Previously, we demonstrated that sepsis induced by cecal ligation and puncture (CLP) impairs [Formula: see text] absorption in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c868f3d5527ae6b5ce298428f8e9526c
https://doi.org/10.1152/ajprenal.00033.2018
https://doi.org/10.1152/ajprenal.00033.2018
Publikováno v:
American Journal of Physiology-Renal Physiology. 313:F103-F115
Monophosphoryl lipid A (MPLA) is a detoxified derivative of LPS that induces tolerance to LPS and augments host resistance to bacterial infections. Previously, we demonstrated that LPS inhibits [Formula: see text] absorption in the medullary thick as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1250cd6d6caf6e80ca5ba60ec507fc3e
https://doi.org/10.1152/ajprenal.00064.2017
https://doi.org/10.1152/ajprenal.00064.2017
Publikováno v:
Am J Physiol Renal Physiol
LPS inhibits [Formula: see text] absorption in the medullary thick ascending limb (MTAL) through a Toll-like receptor 4 (TLR4)-myeloid differentiation factor 88 (MyD88)-extracellular signal-regulated kinase (ERK) pathway that is upregulated by sepsis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b661112a89a7fd140133d02fa8f644d7
https://pubmed.ncbi.nlm.nih.gov/31241993
https://pubmed.ncbi.nlm.nih.gov/31241993
Publikováno v:
American journal of physiology. Renal physiology. 315(3)
Metabolic acidosis is the most common acid-base disorder in septic patients and is associated with increased mortality. Previously, we demonstrated that sepsis induced by cecal ligation and puncture (CLP) impairs [Formula: see text] absorption in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a99cf0cfdcd5da327871ce099f346bd6
https://pubmed.ncbi.nlm.nih.gov/29741098
https://pubmed.ncbi.nlm.nih.gov/29741098
Publikováno v:
American Journal of Physiology-Renal Physiology. 309:F720-F730
High-mobility group box 1 (HMGB1) is a damage-associated molecule implicated in mediating kidney dysfunction in sepsis and sterile inflammatory disorders. HMGB1 is a nuclear protein released extracellularly in response to infection or injury, where i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c797e6d5d1180cc84d72395b6d42db2d
https://doi.org/10.1152/ajprenal.00227.2015
https://doi.org/10.1152/ajprenal.00227.2015
Publikováno v:
American Journal of Physiology-Renal Physiology. 304:F863-F874
Renal insufficiency is a common and severe complication of sepsis, and the development of kidney dysfunction increases morbidity and mortality in septic patients. Sepsis is associated with a variety of defects in renal tubule function, but the underl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b39e7396f073c035c23b960b428e7d
https://doi.org/10.1152/ajprenal.00608.2012
https://doi.org/10.1152/ajprenal.00608.2012
Publikováno v:
American journal of physiology. Renal physiology. 311(3)
High-mobility group box 1 (HMGB1) is a nuclear protein released extracellularly in response to infection or injury, where it activates immune responses and contributes to the pathogenesis of kidney dysfunction in sepsis and sterile inflammatory disor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b954c406d2342cb4ab6d4a19d00d81
https://pubmed.ncbi.nlm.nih.gov/27358052
https://pubmed.ncbi.nlm.nih.gov/27358052
Publikováno v:
American Journal of Physiology-Renal Physiology. 299:F536-F544
Bacterial infection and sepsis are associated with renal tubule dysfunction and dysregulation of systemic electrolyte balance but the underlying mechanisms are incompletely understood. Recently, we demonstrated that HCO3−absorption by the medullary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d3f16fd96965bb2bf8a11a86253717
https://doi.org/10.1152/ajprenal.00108.2010
https://doi.org/10.1152/ajprenal.00108.2010
Publikováno v:
Journal of Biological Chemistry. 283:26602-26611
In the medullary thick ascending limb, inhibiting the basolateral NHE1 Na+/H+ exchanger with nerve growth factor (NGF) induces actin cytoskeleton remodeling that secondarily inhibits apical NHE3 and transepithelial absorption. The inhibition by NGF i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05d8ce46b323d858600433d8885744c9
https://doi.org/10.1074/jbc.m803019200
https://doi.org/10.1074/jbc.m803019200