Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Bruno van Swinderen"'
Autor:
Niki Anthoney, Lucy Tainton-Heap, Hang Luong, Eleni Notaras, Amber B Kewin, Qiongyi Zhao, Trent Perry, Philip Batterham, Paul J Shaw, Bruno van Swinderen
Publikováno v:
eLife, Vol 12 (2023)
Sleep in mammals can be broadly classified into two different physiological categories: rapid eye movement (REM) sleep and slow-wave sleep (SWS), and accordingly REM and SWS are thought to achieve a different set of functions. The fruit fly Drosophil
Externí odkaz:
https://doaj.org/article/e75b510d1f4f41b19288111cbb75b78a
Autor:
Stephane Dissel, Markus K Klose, Bruno van Swinderen, Lijuan Cao, Melanie Ford, Erica M Periandri, Joseph D Jones, Zhaoyi Li, Paul J Shaw
Publikováno v:
PLoS Biology, Vol 20, Iss 9, p e3001797 (2022)
Falling asleep at the wrong time can place an individual at risk of immediate physical harm. However, not sleeping degrades cognition and adaptive behavior. To understand how animals match sleep need with environmental demands, we used live-brain ima
Externí odkaz:
https://doaj.org/article/a185768b26564f07a9095e92797a31a8
Publikováno v:
Frontiers in Systems Neuroscience, Vol 15 (2021)
The brain is a prediction machine. Yet the world is never entirely predictable, for any animal. Unexpected events are surprising, and this typically evokes prediction error signatures in mammalian brains. In humans such mismatched expectations are of
Externí odkaz:
https://doaj.org/article/0a0952984c504c09b01300c36f6d1c85
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 2, p e1008722 (2021)
The physical basis of consciousness remains one of the most elusive concepts in current science. One influential conjecture is that consciousness is to do with some form of causality, measurable through information. The integrated information theory
Externí odkaz:
https://doaj.org/article/545e09fb738847f599311236053bb628
Publikováno v:
PLoS Biology, Vol 18, Iss 8, p e3000548 (2020)
Sleep is vital for survival. Yet under environmentally challenging conditions, such as starvation, animals suppress their need for sleep. Interestingly, starvation-induced sleep loss does not evoke a subsequent sleep rebound. Little is known about ho
Externí odkaz:
https://doaj.org/article/df58b3c58e264e59b52ea1da6de51e29
Autor:
Adekunle T. Bademosi, James Steeves, Shanker Karunanithi, Oressia H. Zalucki, Rachel S. Gormal, Shu Liu, Elsa Lauwers, Patrik Verstreken, Victor Anggono, Frederic A. Meunier, Bruno van Swinderen
Publikováno v:
Cell Reports, Vol 22, Iss 2, Pp 427-440 (2018)
Summary: Propofol is the most commonly used general anesthetic in humans. Our understanding of its mechanism of action has focused on its capacity to potentiate inhibitory systems in the brain. However, it is unknown whether other neural mechanisms a
Externí odkaz:
https://doaj.org/article/63392f39f6834fef94c3eb1372e16020
Autor:
Melvyn H. W. Yap, Martyna J. Grabowska, Chelsie Rohrscheib, Rhiannon Jeans, Michael Troup, Angelique C. Paulk, Bart van Alphen, Paul J. Shaw, Bruno van Swinderen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Sleep in mammals comprises physiologically and functionally distinct stages. Here, the authors report a transitional sleep stage in Drosophila associated with 7–10 Hz oscillatory activity that can be obtained through activation of the sleep-promoti
Externí odkaz:
https://doaj.org/article/aadbc2a0eeea4d43bac3793b8c6b4a16
Autor:
Stephane Dissel, Markus Klose, Jeff Donlea, Lijuan Cao, Denis English, Raphaelle Winsky-Sommerer, Bruno van Swinderen, Paul J. Shaw
Publikováno v:
Neurobiology of Sleep and Circadian Rhythms, Vol 2, Iss , Pp 15-26 (2017)
To test the hypothesis that sleep can reverse cognitive impairment during Alzheimer's disease, we enhanced sleep in flies either co-expressing human amyloid precursor protein and Beta-secretase (APP:BACE), or in flies expressing human tau. The ubiqui
Externí odkaz:
https://doaj.org/article/675989bb79cb445db6e7636bbe1f4110
Autor:
Adekunle T. Bademosi, Elsa Lauwers, Pranesh Padmanabhan, Lorenzo Odierna, Ye Jin Chai, Andreas Papadopulos, Geoffrey J. Goodhill, Patrik Verstreken, Bruno van Swinderen, Frédéric A. Meunier
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
Syntaxin1A (Sx1A) is organized in nanoclusters in neurosecretory cells but how these nanoclusters are affected by neurotransmitter release in a living organism is unknown. Here the authors perform single molecule imaging analysis in live fly larvae a
Externí odkaz:
https://doaj.org/article/c1f4a0305349438cae230c68db71b70f
Autor:
Tong Wang, Sally Martin, Tam H. Nguyen, Callista B. Harper, Rachel S. Gormal, Ramon Martínez-Mármol, Shanker Karunanithi, Elizabeth J. Coulson, Nick R. Glass, Justin J. Cooper-White, Bruno van Swinderen, Frédéric A. Meunier
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Signalling endosomes are known to be essential for neuronal survival. Here the authors show that, in cultured hippocampal neurons and live Drosophilalarval motor neurons, neuronal activity increases the retrograde flux of signalling endosomes, and th
Externí odkaz:
https://doaj.org/article/be42e86f725a40bf81556fbeac83c206