Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Bruno dos Santos Pascoalino"'
Autor:
Érica Araújo Mendes, Denise Regina Bairros de Pilger, Ana Catharina de Seixas Santos Nastri, Fernanda de Mello Malta, Bruno dos Santos Pascoalino, Luiz Augusto Carneiro D’Albuquerque, Andrea Balan, Lucio Holanda Gondim de Freitas, Jr., Edison Luis Durigon, Flair José Carrilho, João Renato Rebello Pinho
Publikováno v:
Annals of Hepatology, Vol 18, Iss 6, Pp 816-824 (2019)
Introduction and objectives: Direct antiviral agents (DAAs) are very efficient in inhibiting hepatitis C virus and might be used to treat infections caused by other flaviviruses whose worldwide detection has recently increased. The aim of this study
Externí odkaz:
https://doaj.org/article/e6dcf05d47514e789fc5df0fb254c25f
Autor:
Jose Xavier-Neto, Murilo Carvalho, Bruno Dos Santos Pascoalino, Alisson Campos Cardoso, Ângela Maria Sousa Costa, Ana Helena Macedo Pereira, Luana Nunes Santos, Ângela Saito, Rafael Elias Marques, Juliana Helena Costa Smetana, Silvio Roberto Consonni, Carla Bandeira, Vivian Vasconcelos Costa, Marcio Chaim Bajgelman, Paulo Sérgio Lopes de Oliveira, Marli Tenorio Cordeiro, Laura Helena Vega Gonzales Gil, Bianca Alves Pauletti, Daniela Campos Granato, Adriana Franco Paes Leme, Lucio Freitas-Junior, Carolina Borsoi Moraes Holanda de Freitas, Mauro Martins Teixeira, Estela Bevilacqua, Kleber Franchini
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005363 (2017)
The teratogenic mechanisms triggered by ZIKV are still obscure due to the lack of a suitable animal model. Here we present a mouse model of developmental disruption induced by ZIKV hematogenic infection. The model utilizes immunocompetent animals fro
Externí odkaz:
https://doaj.org/article/6f2cae316a7d4232bf6c32d084fd5e0a
Autor:
Flavio Di Pisa, Elisa Uliassi, Lucio H. Freitas-Junior, Maria Laura Bolognesi, Antonio Quotadamo, Maria Paola Costi, Claudia Danielli Pereira Bertolacini, Joachim Clos, Joanna Panecka-Hofman, Chiara Borsari, María Jesús Corral, G. Landi, Maria Kuzikov, Deepa Karunakaran, Pasquale Linciano, Wolfgang Müller, Birte Behrens, Kyriakos C. Prousis, Carolina B. Moraes, Lucia Dello Iacono, Markus Wolf, Oliver Keminer, Cecilia Pozzi, Rebecca C. Wade, Bruno dos Santos Pascoalino, José María Alunda, Stefania Ferrari, Martina Fenske, Alberto Venturelli, Sheraz Gul, Jeanette Reinshagen, Nuno Santarém, Matteo Santucci, Jennifer Leu, Stephen Wrigley, Ina Pöhner, Bethlehem Kebede, Theodora Calogeropoulou, Bernhard Ellinger, Stefano Mangani, Anabela Cordeiro-da-Silva, Gesa Witt
Publikováno v:
Slas Discovery
According to the World Health Organization, more than 1 billion people are at risk of or are affected by neglected tropical diseases. Examples of such diseases include trypanosomiasis, which causes sleeping sickness; leishmaniasis; and Chagas disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5b64ff9e20812ab96c4f3ad8331d20
https://hdl.handle.net/11380/1175165
https://hdl.handle.net/11380/1175165
Autor:
Maria Kuzikov, Gesa Witt, Bruno dos Santos Pascoalino, Caio Haddad Franco, Luca Costantino, Rosaria Luciani, Laura M. Alcantara, Nuno Santarém, Sara Macedo, Antonio Quotadamo, Lucio H. Freitas-Junior, Bernhard Ellinger, Carolina B. Moraes, Stefania Ferrari, Maria Paola Costi, Sheraz Gul, Anabela Cordeiro-da-Silva, Pasquale Linciano
Publikováno v:
European Journal of Medicinal Chemistry. 146:423-434
Basing on a library of thiadiazole derivatives showing anti-trypanosomatidic activity, we have considered the thiadiazoles opened forms and reaction intermediates, thiosemicarbazones, as compounds of interest for phenotypic screening against Trypanos
Autor:
Monica S. Sá, Rebecca C. Wade, Claudia Danielli Pereira Bertolacini, Puneet Saxena, Bruno dos Santos Pascoalino, Markus Wolf, Ulrike Wittig, Wolfgang Müller, William N. Hunter, Anabela Cordeiro-da-Silva, Maria Paola Costi, Ina Pöhner, Jeanette Reinshagen, Véronique Hannaert, Nuno Santarém, Pasquale Linciano, Carolina B. Moraes, Philip Gribbon, Alice Dawson, Gesa Witt, Vanessa Fontana, Stefania Ferrari, Laura M. Alcântara, Giuseppe Cannazza, G. Landi, Bernhard Ellinger, Maria Kuzikov, Paul A.M. Michels, Stefano Mangani, David Costa, Erika Nerini, Birte Behrens, Sandra Lazzari, Cecilia Pozzi, Flavio Di Pisa, Lucio H. Freitas-Junior, Luca Costantino, Rosaria Luciani, Sheraz Gul
Publikováno v:
ACS Omega, Vol 2, Iss 9, Pp 5666-5683 (2017)
'ACS Omega ', vol: 2, pages: 5666-5683 (2017)
Linciano, P, Dawson, A, Pöhner, I, Costa, D M, Sa, M S, Cordeiro-Da-Silva, A, Luciani, R, Gul, S, Witt, G, Ellinger, B, Kuzikov, M, Gribbon, P, Reinshagen, J, Wolf, M, Behrens, B, Hannaert, V, Michels, P A M, Nerini, E, Pozzi, C, Di Pisa, F, Landi, G, Santarem, N, Ferrari, S, Saxena, P, Lazzari, S, Cannazza, G, Freitas-Junior, L H, Moraes, C B, Pascoalino, B S, Alcantara, L M, Bertolacini, C P, Fontana, V, Wittig, U, Müller, W, Wade, R C, Hunter, W N, Mangani, S, Costantino, L & Costi, M P 2017, ' Exploiting the 2‑Amino-1,3,4-thiadiazole scaffold to inhibit trypanosoma brucei pteridine reductase in support of early-stage drug discovery ', ACS Omega, vol. 2, no. 9, pp. 5666-5683 . https://doi.org/10.1021/acsomega.7b00473
'ACS Omega ', vol: 2, pages: 5666-5683 (2017)
Linciano, P, Dawson, A, Pöhner, I, Costa, D M, Sa, M S, Cordeiro-Da-Silva, A, Luciani, R, Gul, S, Witt, G, Ellinger, B, Kuzikov, M, Gribbon, P, Reinshagen, J, Wolf, M, Behrens, B, Hannaert, V, Michels, P A M, Nerini, E, Pozzi, C, Di Pisa, F, Landi, G, Santarem, N, Ferrari, S, Saxena, P, Lazzari, S, Cannazza, G, Freitas-Junior, L H, Moraes, C B, Pascoalino, B S, Alcantara, L M, Bertolacini, C P, Fontana, V, Wittig, U, Müller, W, Wade, R C, Hunter, W N, Mangani, S, Costantino, L & Costi, M P 2017, ' Exploiting the 2‑Amino-1,3,4-thiadiazole scaffold to inhibit trypanosoma brucei pteridine reductase in support of early-stage drug discovery ', ACS Omega, vol. 2, no. 9, pp. 5666-5683 . https://doi.org/10.1021/acsomega.7b00473
Pteridine reductase-1 (PTR1) is a promising drug target for the treatment of trypanosomiasis. We investigated the potential of a previously identified class of thiadiazole inhibitors of Leishmania major PTR1 for activity against Trypanosoma brucei (T
Autor:
João Renato Rebello Pinho, Lucio Freitas, Fernanda de Mello Malta, Luiz Augusto Carneiro D'Albuquerque, Ana Catharina de Seixas Santos Nastri, Andrea Balan, Flair José Carrilho, Bruno dos Santos Pascoalino, Erica A. Mendes, Denise Regina Bairros de Pilger, Edison Luis Durigon
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Annals of Hepatology, Vol 18, Iss 6, Pp 816-824 (2019)
Universidade de São Paulo (USP)
instacron:USP
Annals of Hepatology, Vol 18, Iss 6, Pp 816-824 (2019)
Introduction and objectives Direct antiviral agents (DAAs) are very efficient in inhibiting hepatitis C virus and might be used to treat infections caused by other flaviviruses whose worldwide detection has recently increased. The aim of this study w
Autor:
Timothy S. Blackwell, Ana Serezani, Jonathan A. Kropski, K. Vowell, Bruno dos Santos Pascoalino
Publikováno v:
A101. TRANSLATIONAL STUDIES IN ILD, IPF, AND SARCOIDOSIS.
Autor:
Lavínia Maria Dal'Mas Romera, Caio Haddad Franco, Ana Claudia Torrecilhas, Ho Y.A. Au, Carolina B. Moraes, Hai Le, Bruno dos Santos Pascoalino, Tapan Bhattacharyya, Miriam A. Giardini, Rafael Pedro Madeira, Sergio Schenkman, Lucio H. Freitas-Junior, Eric Chatelain, David C. Warhurst, Michael A. Miles
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance, Vol 13, Iss, Pp 107-120 (2020)
International Journal for Parasitology: Drugs and Drug Resistance, Vol 13, Iss, Pp 107-120 (2020)
Ergosterol biosynthesis inhibitors, such as posaconazole and ravuconazole, have been proposed as drug candidates for Chagas disease, a neglected infectious tropical disease caused by the protozoan parasite Trypanosoma cruzi. To understand better the
Autor:
Thiago Cesar Prata Ramos, António Rocha, Nilmar Silvio Moretti, Sergio Schenkman, Leonardo Augusto, Bruno dos Santos Pascoalino, Sheila Cristina Nardelli, Vinícius Santana Nunes
Publikováno v:
Molecular and Biochemical Parasitology. 204:1-10
The histone H4 from Trypanosomatids diverged from other eukaryotes in the N-terminus, a region that undergoes post-translation modifications involved in the control of gene expression, DNA replication, and chromatin assembly. Nonetheless, the N-termi
Autor:
Harikrishna Tanjore, Ana Serezani, William Lawson, Ankita Burman, Linda A. Gleaves, Bruno dos Santos Pascoalino, Carla L. Calvi, Jonathan A. Kropski, Wei Han, Lisa R. Young, Taylor P. Sherrill, Timothy S. Blackwell
Publikováno v:
JCI insight. 3(16)
ER stress in type II alveolar epithelial cells (AECs) is common in idiopathic pulmonary fibrosis (IPF), but the contribution of ER stress to lung fibrosis is poorly understood. We found that mice deficient in C/EBP homologous protein (CHOP), an ER st