Zobrazeno 1 - 10
of 269
pro vyhledávání: '"Bruno Valentin"'
Autor:
Bruno Valentin Sinn, Katharina Sychra, Michael Untch, Thomas Karn, Marion van Mackelenbergh, Jens Huober, Wolfgang Schmitt, Frederik Marmé, Christian Schem, Christine Solbach, Elmar Stickeler, Hans Tesch, Peter A. Fasching, Andreas Schneeweiss, Volkmar Müller, Johannes Holtschmidt, Valentina Nekljudova, Sibylle Loibl, Carsten Denkert
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-11 (2024)
Abstract Background Patients with pathologic complete response (pCR) to neoadjuvant chemotherapy for invasive breast cancer (BC) have better outcomes, potentially warranting less extensive surgical and systemic treatments. Early prediction of treatme
Externí odkaz:
https://doaj.org/article/7254adee1eef456f91cca8c6f84490e2
Autor:
Pauline Wimberger, Jens-Uwe Blohmer, Petra Krabisch, Theresa Link, Marianne Just, Bruno Valentin Sinn, Eike Simon, Christine Solbach, Tanja Fehm, Carsten Denkert, Cristin Kühn, Kerstin Rhiem, Hans Tesch, Sherko Kümmel, Andrea Petzold, Oliver Stötzer, Cornelia Meisel, Jan Dominik Kuhlmann, Valentina Nekljudova, Sibylle Loibl
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-9 (2023)
Abstract Background Disseminated tumor cells (DTCs) in the bone marrow are observed in about 40% at primary diagnosis of breast cancer and predict poor survival. While anti-resorptive therapy with bisphosphonates was shown to eradicate minimal residu
Externí odkaz:
https://doaj.org/article/eb954369b30944128d75b1da2edd9bd4
Autor:
Mattea Reinisch, Michael Untch, Rolf Mahlberg, Toralf Reimer, Thomas Hitschold, Frederik Marmé, Mustafa Aydogdu, Sabine Schmatloch, Hans-Joachim Lück, Marcus Schmidt, Ekkehart Ladda, Bruno Valentin Sinn, Peter Klare, Wolfgang Janni, Christian Jackisch, Carsten Denkert, Sabine Seiler, Thomas Göhler, Laura Michel, Nicole Burchardi, Elmar Stickeler, Julia Rey, Nicole Klutinus, Volker Möbus, Sibylle Loibl
Publikováno v:
Breast, Vol 66, Iss , Pp 110-117 (2022)
Background: Trastuzumab given intravenously in combination with chemotherapy is standard of care for patients with early HER2-positive breast cancer (BC). Different randomised studies have shown equivalent efficacy of a subcutaneous injection into th
Externí odkaz:
https://doaj.org/article/916f38f5626a45b9afb718606995934e
Autor:
Jonas Leichsenring, Valentina Vladimirova, Christine Solbach, Thomas Karn, Beyhan Ataseven, Bruno Valentin Sinn, Jana Barinoff, Volkmar Müller, Jens-Uwe Blohmer, Christian Schem, Knut Engels, Frederik Marmé, Annette Fisseler-Eckhoff, Peter A. Fasching, Elmar Stickeler, Marion van Mackelenbergh, Carsten Denkert, Albrecht Stenzinger, Sibylle Loibl, Stefan Gröschel
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-10 (2022)
Abstract Background Overexpression of the EVI1 (ecotropic viral integration site 1) oncogene has recently been implicated as a prognostic factor in breast cancer (BC), particularly in triple-negative BC (TNBC). In this study we aimed to investigate f
Externí odkaz:
https://doaj.org/article/c3d9b3683e1d4e1b93d349f80d056d05
Autor:
Sefer Elezkurtaj, Selina Greuel, Jana Ihlow, Edward Georg Michaelis, Philip Bischoff, Catarina Alisa Kunze, Bruno Valentin Sinn, Manuela Gerhold, Kathrin Hauptmann, Barbara Ingold-Heppner, Florian Miller, Hermann Herbst, Victor Max Corman, Hubert Martin, Helena Radbruch, Frank L. Heppner, David Horst
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Infection by the new corona virus strain SARS-CoV-2 and its related syndrome COVID-19 has been associated with more than two million deaths worldwide. Patients of higher age and with preexisting chronic health conditions are at an increased
Externí odkaz:
https://doaj.org/article/87b08c6236304a3d8e02d2752ab143b8
Autor:
Bruno Valentin Sinn, Karsten E. Weber, Wolfgang Daniel Schmitt, Peter A. Fasching, William Fraser Symmans, Jens-Uwe Blohmer, Thomas Karn, Eliane Tabea Taube, Frederick Klauschen, Frederik Marmé, Christian Schem, Elmar Stickeler, Beyhan Ataseven, Jens Huober, Gunter von Minckwitz, Barbara Seliger, Carsten Denkert, Sibylle Loibl
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-9 (2019)
Abstract Background Clinical application of cancer immunotherapy requires a better understanding of tumor immunogenicity and the tumor microenvironment. HLA class I molecules present antigens to CD8+ cytotoxic cells. Their loss or downregulation is f
Externí odkaz:
https://doaj.org/article/fe25c57ca712482c9d848c7a1e558deb
Autor:
Jana Käthe Striefler, Hanno Riess, Philipp Lohneis, Sven Bischoff, Annika Kurreck, Dominik Paul Modest, Marcus Bahra, Helmut Oettle, Marianne Sinn, Henrik Bläker, Carsten Denkert, Sebastian Stintzing, Bruno Valentin Sinn, Uwe Pelzer
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundThe Mucin-family protein, MUC1, impacts on carcinogenesis and tumor invasion. We evaluated the impact of MUC1 expression on outcome in a cohort of 158 patients with resected pancreatic ductal adenocarcinomas (PDAC) in the CONKO-001 study (a
Externí odkaz:
https://doaj.org/article/c46c33f0aa6a4faeb2215126a5c9b5db
Autor:
Berit Maria Müller, Elke Keil, Annika Lehmann, Klaus-Jürgen Winzer, Christiane Richter-Ehrenstein, Judith Prinzler, Nikola Bangemann, Angela Reles, Sylvia Stadie, Winfried Schoenegg, Jan Eucker, Marcus Schmidt, Frank Lippek, Korinna Jöhrens, Stefan Pahl, Bruno Valentin Sinn, Jan Budczies, Manfred Dietel, Carsten Denkert
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e68252 (2013)
The validated EndoPredict assay is a novel tool to predict the risk of metastases of patients with estrogen receptor positive, HER2 negative breast cancer treated with endocrine therapy alone. It has been designed to integrate genomic and clinical in
Externí odkaz:
https://doaj.org/article/ae95c19dc59548368152647d4ca103a0
Autor:
Yasmin Issa-Nummer, Silvia Darb-Esfahani, Sibylle Loibl, Georg Kunz, Valentina Nekljudova, Iris Schrader, Bruno Valentin Sinn, Hans-Ullrich Ulmer, Ralf Kronenwett, Marianne Just, Thorsten Kühn, Kurt Diebold, Michael Untch, Frank Holms, Jens-Uwe Blohmer, Jörg-Olaf Habeck, Manfred Dietel, Friedrich Overkamp, Petra Krabisch, Gunter von Minckwitz, Carsten Denkert
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e79775 (2013)
We have recently described an increased lymphocytic infiltration rate in breast carcinoma tissue is a significant response predictor for anthracycline/taxane-based neoadjuvant chemotherapy (NACT). The aim of this study was to prospectively validate t
Externí odkaz:
https://doaj.org/article/faa195c3a48443908de3f52402409581
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