Výsledky vyhledávání - "Bruno Sevá-Pessôa"

The adipose tissue and the involvement of the renin–angiotensin–aldosterone system in cardiometabolic syndrome

Autor: Bruno Sevá-Pessôa, Dora Maria Grassi-Kassisse, Filipy Borghi

Publikováno v: Cell and Tissue Research. 366:543-548

Cardiometabolic diseases are linked to a cluster of modifiable factors, including risk factors closely related to central adiposity. Chronic renin-angiotensin-aldosterone system (RAAS) activation has far-reaching effects on cardiometabolic risk and i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13bb5e59631a3b3a925ee664dddeb3a
https://doi.org/10.1007/s00441-016-2515-6

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Angiotensin II Type 2 Receptor- and Acetylcholine-Mediated Relaxation

Autor: A.H. Jan Danser, Ingrid M. Garrelds, Anton J.M. Roks, Aldo Grefhorst, Denise E. Slump, Richard van Veghel, Khatera Ibrahimi, Bruno Sevá Pessôa, Steven A. Kushner, Joep H.M. van Esch

Publikováno v: Hypertension, 66(2), 396-402. Lippincott Williams & Wilkins
Hypertension, 66(2), 396-402. Lippincott Williams and Wilkins

Angiotensin-induced vasodilation, involving type 2 receptor (AT 2 R)–induced generation of nitric oxide (NO; by endothelial NO synthase) and endothelium-derived hyperpolarizing factors, may be limited to women. To distinguish the contribution of fe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aff3838741c0d6862a0be738c128200a
http://www.scopus.com/inward/record.url?scp=84937564197&partnerID=8YFLogxK

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Key developments in renin-angiotensin-aldosterone system inhibition

Autor: A.H. Jan Danser, Koen Verdonk, Bruno Sevá Pessôa, Nils van der Lubbe, Ewout J. Hoorn, Anton J.M. Roks

Publikováno v: Nature Reviews Nephrology, 9(1), 26-36. Nature Publishing Group

The development of blockers of the renin–angiotensin–aldosterone system (RAAS) has led to the identification of new RAAS components that might contribute to the effectiveness and/or adverse effects of these drugs. Here, the authors describe the r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e473b4d607376f732be2daab5ead1c3b
https://pure.eur.nl/en/publications/5171d997-b05f-40c7-be2d-d686e95d9fe0

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The renin-angiotensin system, bone marrow and progenitor cells

Autor: Matej Durik, Bruno Sevá Pessôa, Anton J.M. Roks

Publikováno v: Clinical Science, 123(3-4), 205-223. Portland Press, Ltd.

Modulation of the RAS (renin–angiotensin system), in particular of the function of the hormones AngII (angiotensin II) and Ang-(1–7) [angiotensin-(1–7)], is an important target for pharmacotherapy in the cardiovascular system. In the classical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::378ce00a486eaa42078d20f32b9827c8
https://doi.org/10.1042/cs20110660

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Effect of a stable Angiotensin-(1-7) analogue on progenitor cell recruitment and cardiovascular function post myocardial infarction

Autor: Richard van Veghel, Bruno Sevá Pessôa, Anton J.M. Roks, A.H. Jan Danser, Heleen M.M. van Beusekom, Stefan Sneep, René de Vries, Vincent H.J. van der Velden, Dennie Tempel, Peter Moritz Becher, Dirk Westermann

Publikováno v: Journal of the American Heart Association, 4(2). Wiley-Blackwell
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association, 4(2). Wiley

Background Angiotensin‐(1–7) improves cardiac function and remodeling after myocardial infarction (MI). This may involve recruitment of hematopoietic progenitor cells that support angiogenesis. However, angiotensin‐(1–7) is rapidly metabolize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50dc48e4586fcf2b584a7646f4577612
https://dspace.library.uu.nl/handle/1874/332609

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Multiple ascending dose study with the new renin inhibitor VTP-27999: nephrocentric consequences of too much renin inhibition

Autor: Catherine Bryson, Bruno Sevá Pessôa, Joël Ménard, Richard Gregg, Michel Azizi, A.H. Jan Danser, Ingrid M. Garrelds, Sue G. Griffith, Gerard McGeehan, Richard A. Reeves, Joanna Balcarek

Publikováno v: Hypertension, 63(5), 942-950. Lippincott Williams & Wilkins

This study compared the pharmacodynamic/pharmacokinetic profile of the new renin inhibitor VTP-27999 in salt-depleted healthy volunteers, administered once daily (75, 150, 300, and 600 mg) for 10 days, versus placebo and 300 mg aliskiren. VTP-27999 w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c8c25088bfa5fb4bc906207e04ffef
https://pubmed.ncbi.nlm.nih.gov/24470465

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Abstract 197: Effects of a Stabile Angiotensin-(1-7) Analogue, Cyclic Angiotensin-(1-7), on Progenitor Cell Recruitment and Cardiac Remodeling

Autor: Bruno Sevá Pessôa, Richard van Veghel, A.H. Jan Danser, Anton J.M. Roks

Publikováno v: Hypertension. 62

Objectives: In animal models, angiotensin-(1-7) treatment has beneficial effects improving cardiac function and remodeling after myocardial infarction (MI). Angiotensin-(1-7) might have a beneficial angiogenic effect after MI, since infusion increase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a62dfcbb3aebc45054a59e6a2a9cc58
https://doi.org/10.1161/hyp.62.suppl_1.a197

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Spironolactone improves nephropathy by enhancing glucose-6-phosphate dehydrogenase activity and reducing oxidative stress in diabetic hypertensive rat

Autor: José B. Lopes de Faria, Alexandros Papadimitriou, Bruno Sevá Pessôa, Jacqueline M. Lopes de Faria, Elisa B.M.I. Peixoto

Publikováno v: Journal of the Renin-Angiotensin-Aldosterone System, Vol 13 (2012)

Spironolactone (SPR), a mineralocorticoid receptor blocker, diminishes hyperglycemia-induced reduction in glucose-6-phosphate dehydrogenase (G6PD) activity, improving oxidative stress damage. This study investigated whether SPR ameliorates nephropath

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e280a76c9398717cf14b0c9c0dffbb8
https://doaj.org/article/5ed17786b3264c47aecb5f5935abeb7c

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Mineralocorticoid receptor blockade ameliorates nephropathy by increasing glucose-6-phosphate dehydrogenase activity and reducing oxidative stress in diabetic hypertensive rats

Autor: Bruno Sevá Pessôa

Publikováno v: Biblioteca Digital de Teses e Dissertações da Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual de Campinas (UNICAMP)
instacron:UNICAMP

Orientador: José Butori Lopes de Faria Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas Resumo: Foi demonstrado, em modelos de diabetes tipo 1 e tipo 2, que o uso de espironolactona (SPR), um antagonista

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