Glyceric Prodrug of Ursodeoxycholic Acid (UDCA): Novozym 435-Catalyzed Synthesis of UDCA-Monoglyceride

Autor: Federico Zappaterra, Stefania Costa, Daniela Summa, Bruno Semeraro, Virginia Cristofori, Claudio Trapella, Elena Tamburini

Publikováno v: Molecules, Vol 26, Iss 19, p 5966 (2021)

Bile acids (BAs) are a family of steroids synthesized from cholesterol in the liver. Among bile acids, ursodeoxycholic acid (UDCA) is the drug of choice for treating primary biliary cirrhosis and dissolving cholesterol gallstones. The clinical effect

Externí odkaz: https://doaj.org/article/c9fd5b8ce683481698b43f764b101d7c

Biotransformation of Cortisone with Rhodococcus rhodnii: Synthesis of New Steroids

Autor: Federico Zappaterra, Stefania Costa, Daniela Summa, Valerio Bertolasi, Bruno Semeraro, Paola Pedrini, Raissa Buzzi, Silvia Vertuani

Publikováno v: Molecules, Vol 26, Iss 5, p 1352 (2021)

Cortisone is a steroid widely used as an anti-inflammatory drug able to suppress the immune system, thus reducing inflammation and attendant pain and swelling at the site of an injury. Due to its numerous side effects, especially in prolonged and hig

Externí odkaz: https://doaj.org/article/e84bd7bbd6854f498231370058e05025

Fermentation as a Strategy for Bio-Transforming Waste into Resources: Lactic Acid Production from Agri-Food Residues

Autor: Stefania Costa, Daniela Summa, Bruno Semeraro, Federico Zappaterra, Irene Rugiero, Elena Tamburini

Publikováno v: Fermentation, Vol 7, Iss 1, p 3 (2020)

Lactic acid (LA) obtained by fermentation of carbohydrates is well-known and widely used in the food sector. This process is as an alternative to the chemical synthesis and ensures several advantages especially in terms of environmental sustainabilit

Externí odkaz: https://doaj.org/article/e7f3a1cfe2f94f448a397e67236c11d5

Δ1-Dehydrogenation and C20 Reduction of Cortisone and Hydrocortisone Catalyzed by Rhodococcus Strains

Autor: Stefania Costa, Federico Zappaterra, Daniela Summa, Bruno Semeraro, Giancarlo Fantin

Publikováno v: Molecules, Vol 25, Iss 9, p 2192 (2020)

Prednisone and prednisolone are steroids widely used as anti-inflammatory drugs. Development of the pharmaceutical industry is currently aimed at introducing biotechnological processes and replacing multiple-stage chemical syntheses. In this work we

Externí odkaz: https://doaj.org/article/7f53445f42c9498781487f60cd2ec83a

Biocatalytic approach for direct esterification of ibuprofen with sorbitol in biphasic media

Autor: Bruno Semeraro, Federico Zappaterra, Maria Elena Maldonado Rodriguez, Elena Tamburini, Daniela Summa, Stefania Costa

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 6
International Journal of Molecular Sciences, Vol 22, Iss 3066, p 3066 (2021)

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) introduced in the 1960s and widely used as an analgesic, anti-inflammatory, and antipyretic. In its acid form, the solubility of 21 mg/L greatly limits its bioavailability. Since the bioavail

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f222a39fa9a730a83485c4a5b568cc0c
http://hdl.handle.net/11392/2464437