AVANÇOS RECENTES EM BIOSSÍNTESE COMBINATÓRIA DE POLICETÍDEOS: PERSPECTIVAS E DESAFIOS

Autor: Bruno S. Paulo, Renata Sigrist, Luciana G. de Oliveira

Publikováno v: Química Nova, Vol 42, Iss 1, Pp 71-83

Natural products continue to inspire scientists on the search for biological active structures. Recent advances in synthetic biology allow modifying genes to extend structural diversity present on natural products by changing important functional gro

Externí odkaz: https://doaj.org/article/61977b9462aa4e79a58b51c1893d1094

Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products

Autor: Luciana G. de Oliveira, Renata Sigrist, Bruno S. Paulo, Célio F. F. Angolini

Publikováno v: Journal of Visualized Experiments.

The chemical space covered by natural products is immense and widely unrecognized. Therefore, convenient methodologies to perform wide-ranging evaluation of their functions in nature and potential human benefits (e.g., for drug discovery applications

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919c0fb64a971f1fc73c3671974cbbcf
https://doi.org/10.3791/60825-v

Recent Advances in Genetic Manipulation of Organisms for the Production of Nonribosomal Peptides

Autor: Renata Sigrist, Gabriela Desiree Tormet Gonzalez, Bruno S. Paulo

Publikováno v: Revista Virtual de Química. 8:1998-2025

Os peptideos nao ribossomais (NRP) sao uma classe de produtos naturais produzidos, principalmente, por bacterias e fungos filamentosos. Estes compostos sao biossintetizados atraves de um maquinario enzimatico multimodular responsavel pela insercao, e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb394081f7d2489f0fe6020a19157a60
https://doi.org/10.21577/1984-6835.20160135

Gene Deletion Leads to Improved Valinomycin Production by Streptomyces sp. CBMAI 2042

Autor: Renata Sigrist, Bruno S. Paulo, Marcos N. Eberlin, Luciana G. de Oliveira, Célio F. F. Angolini

Publikováno v: Journal of the Brazilian Chemical Society v.30 n.3 2019
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ
Journal of the Brazilian Chemical Society, Volume: 30, Issue: 3, Pages: 673-679, Published: MAR 2019

The genus Streptomyces represents one of the largest producers of molecules with antibiotic activity. The whole genome sequencing of the endophytic microorganism Streptomyces sp. CBMAI 2042 revealed 35 gene clusters encoding for secondary metabolism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e28098d87ac4d7ae889c69ab4dfc075d
https://doi.org/10.21577/0103-5053.20180207

Genome Mining of EndophyticStreptomyces wadayamensisReveals High Antibiotic Production Capability

Autor: Luciana G. de Oliveira, Markiyan Samborskyy, Pedro Luiz R. Cruz, Célio F. F. Angolini, Bruno S. Paulo, Ana Beatriz Goncalves, Marcos N. Eberlin, Adriana Fu Vivian, Renata Sigrist, Eduardo Morgado Schmidt, Welington Luiz Araújo

Publikováno v: Journal of the Brazilian Chemical Society.

The actinobacteria Streptomyces wadayamensis A23, an endophitic strain, was recently sequenced and previous work showed qualitatively that the strain inhibits the growth of some pathogens. Herein we report the genome analysis of S. wadayamensis which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cae3f9354f17fb398a2ec45d08aed858
https://doi.org/10.5935/0103-5053.20160180