Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Bruno Pradier"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
The inhibitory function of GABA at the spinal level and its central modulation in the brain are essential for pain perception. However, in post-surgical pain, the exact mechanism and modes of action of GABAergic transmission have been poorly studied.
Externí odkaz:
https://doaj.org/article/7e35591cb14349edaaf5c282420ad0f5
Autor:
Hui-Fen Chen, Henriette Lambers, Nina Nagelmann, Martin Sandbrink, Daniel Segelcke, Esther Pogatzki-Zahn, Cornelius Faber, Bruno Pradier
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
BOLD fMRI has become a prevalent method to study cerebral sensory processing in rodent disease models, including pain and mechanical hypersensitivity. fMRI data analysis is frequently combined with a general-linear-model (GLM) -based analysis, which
Externí odkaz:
https://doaj.org/article/2c16d823fa044aa8857ed7e36ecaf782
Autor:
Anke Tappe-Theodor, Claudia Pitzer, Lars Lewejohann, Paulin Jirkof, Katja Siegeler, Astra Segelcke, Natascha Drude, Bruno Pradier, Esther Pogatzki-Zahn, Britta Hollinderbäumer, Daniel Segelcke
Publikováno v:
Frontiers in Veterinary Science, Vol 9 (2022)
The prospective severity assessment in animal experiments in the categories' non-recovery, mild, moderate, and severe is part of each approval process and serves to estimate the harm/benefit. Harms are essential for evaluating ethical justifiability,
Externí odkaz:
https://doaj.org/article/6710302be71640a7b86a5a4dfea7f037
Autor:
Bruno Pradier, Lydia Wachsmuth, Nina Nagelmann, Daniel Segelcke, Silke Kreitz, Andreas Hess, Esther M. Pogatzki-Zahn, Cornelius Faber
Publikováno v:
NeuroImage, Vol 245, Iss , Pp 118626- (2021)
For fMRI in animal models, the combination of low-dose anesthetic, isoflurane (ISO), and the sedative medetomidine (MED) has recently become an advocated regimen to achieve stable neuronal states and brain networks in rats that are required for relia
Externí odkaz:
https://doaj.org/article/4f043c323b3e4914aa3325c4b08d3592
Publikováno v:
Frontiers in Pain Research, Vol 2 (2021)
In recent years, preclinical pain research has failed to develop genuinely new analgesics for clinical use. This fact is reflected by a high number of patients, limited drug efficacy accompanied by side effects, and a long-term opioid intake. Two mai
Externí odkaz:
https://doaj.org/article/c5597a509db74c40901decca16088127
Autor:
Bruno Pradier, Samuel J. McCormick, Ayumi C. Tsuda, Rudy W. Chen, Abigail L. Atkinson, Mollie R. Westrick, Caroline L. Buckholtz, Julie A. Kauer
Publikováno v:
Physiological Reports, Vol 7, Iss 12, Pp n/a-n/a (2019)
Abstract The trigeminal nucleus caudalis (TNc) receives extensive afferent innervation from peripheral sensory neurons of the trigeminal ganglion (TG), and is the first central relay in the circuitry underpinning orofacial pain. Despite the initial c
Externí odkaz:
https://doaj.org/article/37ebe2be67b746909e7c5a1b34df82ea
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222066 (2019)
Of the fast ionotropic synapses, glycinergic synapses are the least well understood, but are vital for the maintenance of inhibitory signaling in the brain and spinal cord. Glycinergic signaling comprises half of the inhibitory signaling in the spina
Externí odkaz:
https://doaj.org/article/7d5fb1c21bed4a2995567e3c71ab1e2a
Autor:
Daniel Segelcke, Max van der Burgt, Christin Kappert, Daniela Schmidt Garcia, Julia R. Sondermann, Stephan Bigalke, Bruno Pradier, David Gomez-Varela, Peter K. Zahn, Manuela Schmidt, Esther M. Pogatzki-Zahn
Publikováno v:
British Journal of Anaesthesia
Background:Acute pain after surgery is common and often leads to chronic post-surgical pain, but neither treatment nor prevention is currently sufficient. We hypothesised that specific protein networks (protein-protein interactions) are relevant for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a73bda872dfd33717d17740f706c065f
https://hdl.handle.net/21.11116/0000-000C-D047-921.11116/0000-000C-D045-B
https://hdl.handle.net/21.11116/0000-000C-D047-921.11116/0000-000C-D045-B
Autor:
Daniel Segelcke, Jan Linnemann, Bruno Pradier, Daniel Kronenberg, Richard Stange, Helene Richter, Dennis Görlich, Nicola Baldini, Gemma Di Pompo, Waldiceu A. Verri, Sofia Avnet, Esther Pogatzki-Zahn
Cancer-induced bone pain (CIBP) is a common and devastating symptom with limited treatment options in patients, significantly affecting their quality of life. To uncover the mechanisms underlying CIBP, using rodent models is the most common approach;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e9629322e72d3fdfdf6bdd32362e195
https://doi.org/10.1101/2022.11.19.517016
https://doi.org/10.1101/2022.11.19.517016
Autor:
Daniel Segelcke, Max van der Burgt, Bruno Pradier, Daniela Rosenberger, Philipp André Macháček, Johanna Jolmes, Jan Vollert, Esther Pogatzki-Zahn
Background Understanding the (patho-) physiology of pain after surgery is incomplete; this hampers the effective treatment and leads to long-term consequences, including complications, chronification of pain, and potential drug misuse. Evidence-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bb447c2b6536af302f344879ad51169
https://doi.org/10.21203/rs.3.rs-2276317/v1
https://doi.org/10.21203/rs.3.rs-2276317/v1