Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Bruno Pitard"'
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 743-757 (2023)
Genetic immunization is an attractive approach for prophylactic and therapeutic vaccination using synthetic vectors to deliver antigen-encoding nucleic acids. Recently, DNA delivered by a physical means or RNA by liposomes consisting of four differen
Externí odkaz:
https://doaj.org/article/17cc09afef0942bb9b719190f63c580c
Autor:
Camille Chauvin, Laurine Levillayer, Mathilde Roumier, Hubert Nielly, Claude Roth, Anupama Karnam, Srinivasa Reddy Bonam, Anne Bourgarit, Clément Dubost, Aurore Bousquet, Sébastien Le Burel, Raphaële Mestiri, Damien Sene, Joris Galland, Marc Vasse, Matthieu Groh, Mathilde Le Marchand, Camille Vassord-Dang, Jean-François Gautier, Nhan Pham-Thi, Christiane Verny, Bruno Pitard, Cyril Planchais, Hugo Mouquet, Richard Paul, Etienne Simon-Loriere, Jagadeesh Bayry, Laurent Gilardin, Anavaj Sakuntabhai
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106124- (2023)
Summary: Although tocilizumab treatment in severe and critical coronavirus disease 2019 (COVID-19) patients has proven its efficacy at the clinical level, there is little evidence supporting the effect of short-term use of interleukin-6 receptor bloc
Externí odkaz:
https://doaj.org/article/7f719db0590747f480efa6dc91b53b8f
Autor:
Gabriel Araujo Tavares, Amada Torres, Gwenola Le Drean, Maïwenn Queignec, Blandine Castellano, Laurent Tesson, Séverine Remy, Ignacio Anegon, Bruno Pitard, Bertrand Kaeffer
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 191 (2022)
To investigate if the artificial delivery of microRNAs naturally present in the breastmilk can impact the gut and brain of young rats according to weaning. Animals from a new transgenic rat line expressing the green-fluorescent protein in the endocri
Externí odkaz:
https://doaj.org/article/475ed61117ed4d7c8ab0b63d26e0aea3
Autor:
Ignacio Caballero, Mickaël Riou, Océane Hacquin, Claire Chevaleyre, Céline Barc, Jérémy Pezant, Anne Pinard, Julien Fassy, Roger Rezzonico, Bernard Mari, Nathalie Heuzé-Vourc’h, Bruno Pitard, Georges Vassaux
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 16, Iss , Pp 186-193 (2019)
Tetrafunctional block copolymers are molecules capable of complexing DNA. Although ineffective in vitro, studies in mice have shown that the tetrafunctional block copolymer 704 is a more efficient lung gene transfer agent than the cationic liposome G
Externí odkaz:
https://doaj.org/article/e2b5b9d4e0984799b13ae116dcb13d80
Autor:
Emmeline L. Blanchard, Kristin H. Loomis, Sushma M. Bhosle, Daryll Vanover, Patrick Baumhof, Bruno Pitard, Chiara Zurla, Philip J. Santangelo
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 14, Iss , Pp 52-66 (2019)
The characterization of innate immune activation is crucial for vaccine and therapeutic development, including RNA-based vaccines, a promising approach. Current measurement methods quantify type I interferon and inflammatory cytokine production, but
Externí odkaz:
https://doaj.org/article/ce9a7b51eb514c22a442138d2bda3bc5
Autor:
Tony Le Gall, Mathieu Berchel, Lee Davies, Angélique Mottais, Rosy Ghanem, Alain Fautrel, Deborah Gill, Steve Hyde, Pierre Lehn, Jean-Marie Lehn, Loïc Lemiègre, Thierry Benvegnu, Paul-Alain Jaffrès, Bruno Pitard, Tristan Montier
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 25 (2021)
Aerosol lung gene therapy using non-viral delivery systems represents a credible therapeutic strategy for chronic respiratory diseases, such as cystic fibrosis (CF). Progress in CF clinical setting using the lipidic formulation GL67A has demonstrated
Externí odkaz:
https://doaj.org/article/3ac96a9742de4b9ca532dc89bdc93c79
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
ContextSpecific targeting of endogenous miRNAs which are involved in epigenetics, may help understanding homeostasis with therapeutic benefits. We use new biologically inspired vehicles consisting of lipoaminoglycosides to deliver in vivo mir-320-3p,
Externí odkaz:
https://doaj.org/article/2450bfe2f8d74dbf81aacea3e4878b9b
Autor:
Thibault Colombani, Thomas Haudebourg, Marion Decossas, Olivier Lambert, Grace Ada Da Silva, Frederic Altare, Bruno Pitard
Publikováno v:
Advanced Science, Vol 6, Iss 16, Pp n/a-n/a (2019)
Abstract Development of simple and fully characterized immunomodulatory molecules is an active area of research to enhance current immunotherapies. Monophosphoryl lipid A (MPL), a nontoxic lipidic derivative from bacteria, is the first and currently
Externí odkaz:
https://doaj.org/article/e6aa4029364f413da133b7eb9f4f7f06
Autor:
Benoît Chatin, Mathieu Mével, Julie Devallière, Laurence Dallet, Thomas Haudebourg, Pauline Peuziat, Thibault Colombani, Mathieu Berchel, Olivier Lambert, Aleksander Edelman, Bruno Pitard
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 4, Iss C (2015)
The intracellular delivery of biologically active protein represents an important emerging strategy for both fundamental and therapeutic applications. Here, we optimized in vitro delivery of two functional proteins, the β-galactosidase (β-gal) enzy
Externí odkaz:
https://doaj.org/article/7ae6901b112f44ed956666a18b9459df
Autor:
Camille Rolland-Debord, David Lair, Tiphaine Roussey-Bihouée, Dorian Hassoun, Justine Evrard, Marie-Aude Cheminant, Julie Chesné, Faouzi Braza, Guillaume Mahay, Vincent Portero, Christine Sagan, Bruno Pitard, Antoine Magnan
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85976 (2014)
BackgroundAllergic asthma is caused by abnormal immunoreactivity against allergens such as house dust mites among which Dermatophagoides farinae (Der f) is a common species. Currently, immunotherapy is based on allergen administration, which has vari
Externí odkaz:
https://doaj.org/article/6b1f31557e3143d0a1b8ff42dd6b6c3e