Výsledky vyhledávání - "Bruno Montanari"

Akademický článek

Extracellular vesicles from virulent P. brasiliensis induce TLR4 and dectin-1 expression in innate cells and promote enhanced Th1/Th17 response

Autor: Bruno Montanari Borges, Monique Gama de Santana, Nycolas Willian Preite, Valéria de Lima Kaminski, Gabriel Trentin, Fausto Almeida, Flávio Vieira Loures

Publikováno v: Virulence, Vol 15, Iss 1 (2024)

ABSTRACTExtracellular vesicles (EVs) are membrane-enclosed nanoparticles that transport several biomolecules and are involved in important mechanisms and functions related to the pathophysiology of fungal diseases. EVs from Paracoccidioides brasilien

Externí odkaz: https://doaj.org/article/8509b72c16664bc38cbfbb5bce77446b

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Akademický článek

MDSCs use a complex molecular network to suppress T-cell immunity in a pulmonary model of fungal infection

Autor: Valéria Lima Kaminski, Bruno Montanari Borges, Bianca Vieira Santos, Nycolas Willian Preite, Vera Lucia Garcia Calich, Flávio Vieira Loures

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)

BackgroundParacoccidioidomycosis (PCM) is a systemic endemic fungal disease prevalent in Latin America. Previous studies revealed that host immunity against PCM is tightly regulated by several suppressive mechanisms mediated by tolerogenic plasmacyto

Externí odkaz: https://doaj.org/article/11d84f92488b4fcf9accbaf4d1190a89

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Akademický článek

Blocking the CTLA-4 and PD-1 pathways during pulmonary paracoccidioidomycosis improves immunity, reduces disease severity, and increases the survival of infected mice

Autor: Nycolas Willian Preite, Bruno Montanari Borges, Valéria de Lima Kaminski, Marina Caçador Ayupe, Leonardo Mandu Gonçalves, Bianca Vieira dos Santos, Dennyson Leandro M. Fonseca, Igor Salerno Filgueiras, Caio Loureiro Salgado, Sandra Marcia Muxel, Otavio Cabral-Marques, Denise Morais da Fonseca, Flávio Vieira Loures, Vera Lúcia Garcia Calich

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Immune checkpoint pathways, i.e., coinhibitory pathways expressed as feedback following immune activation, are crucial for controlling an excessive immune response. Cytotoxic T lymphocyte antigen-4 (CTLA-4) and programmed cell death protein-1 (PD-1)

Externí odkaz: https://doaj.org/article/12834ac8b4974877b8ed4fc1e4302adf

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Akademický článek

The immunosuppressive activity of myeloid-derived suppressor cells in murine Paracoccidioidomycosis relies on Indoleamine 2,3-dioxygenase activity and Dectin-1 and TLRs signaling

Autor: Valéria de Lima Kaminski, Nycolas Willian Preite, Bruno Montanari Borges, Bianca Vieira dos Santos, Vera Lucia Garcia Calich, Flávio Vieira Loures

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)

Abstract Paracoccidioidomycosis (PCM) is a systemic mycosis with a high incidence in Latin America. Prior studies have demonstrated the significance of the enzyme Indoleamine 2,3-dioxygenase (IDO-1) in the immune regulation of PCM as well as the vita

Externí odkaz: https://doaj.org/article/83ef65b943ee43b8a30f72c6698a8b5f

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Akademický článek

Standards no direito contratual: intersecções da reasonableness e da boa-fé

Autor: Bruno Montanari Rostro, Henrique Beux Nassif Azem, Rodrigo Ustárroz Cantali

Publikováno v: Civilistica.com, Vol 12, Iss 1, Pp 1-34 (2023)

Este estudo tem por objetivo analisar se, em uma perspectiva comparatista funcional, a noção de boa-fé objetiva, presente no sistema romano-germânico, é funcionalmente equivalente à de good faith anglo-americana, ou se a common law ofereceria a

Externí odkaz: https://doaj.org/article/8daca13f59d646ca8e2a282e16f17966

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Akademický článek

Transcriptional profiling of a fungal granuloma reveals a low metabolic activity of Paracoccidioides brasiliensis yeasts and an actively regulated host immune response

Autor: Bruno Montanari Borges, Rafael Berton Correia Ramos, Nycolas Willian Preite, Valéria de Lima Kaminski, Patrícia Alves de Castro, Maurício Camacho, Marina Ferreira Maximo, Taicia Pacheco Fill, Vera Lúcia Garcia Calich, Aimee M. Traynor, Özlem Sarikaya-Bayram, Sean Doyle, Özgür Bayram, Claudia Barbosa Ladeira de Campos, André Zelanis, Gustavo H. Goldman, Flávio Vieira Loures

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)

Granulomas are important immunological structures in the host defense against the fungus Paracoccidioides brasiliensis, the main etiologic agent of Paracoccidioidomycosis (PCM), a granulomatous systemic mycosis endemic in Latin America. We have perfo

Externí odkaz: https://doaj.org/article/68a73958ff004898a97f1b937a00e98a

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Akademický článek

Myeloid-derived suppressor cells are associated with impaired Th1 and Th17 responses and severe pulmonary paracoccidioidomycosis which is reversed by anti-Gr1 therapy

Autor: Nycolas Willian Preite, Valéria de Lima Kaminski, Bruno Montanari Borges, Vera Lúcia Garcia Calich, Flávio Vieira Loures

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Previous studies on paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in Latin America, revealed that host immunity is tightly regulated by several suppressive mechanisms mediated by tolerogenic plasmacytoid dendritic cells, the enzym

Externí odkaz: https://doaj.org/article/125175ece6374b4ba8ff75fcef9a852b

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Akademický článek

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