Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Bruno Martoglio"'
Autor:
Anita Schlierf, Eva Altmann, Jean Quancard, Anne B. Jefferson, René Assenberg, Martin Renatus, Matthew Jones, Ulrich Hassiepen, Michael Schaefer, Michael Kiffe, Andreas Weiss, Christian Wiesmann, Richard Sedrani, Jörg Eder, Bruno Martoglio
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Dysregulation of protein degradation by the ubiquitin-proteasome system is a feature commonly associated with cancer. Here, the authors develop an orally available small molecule that inhibits CSN5, the proteolytic subunit of the COP9 signalosome, an
Externí odkaz:
https://doaj.org/article/6813730e8c8647398b624ca609051b9b
Autor:
Ulrike Obst-Sander, Antonio Ricci, Bernd Kuhn, Thomas Friess, Philipp Koldewey, Andreas Kuglstatter, David Hewings, Annick Goergler, Sandra Steiner, Daniel Rueher, Marie-Paule Imhoff, Noemi Raschetti, Hans-Peter Marty, Aline Dietzig, Caroline Rynn, Andreas Ehler, Dominique Burger, Martin Kornacker, Jeannine Petrig Schaffland, Frank Herting, William Pao, James R. Bischoff, Bruno Martoglio, Yvonne Alice Nagel, Georg Jaeschke
Publikováno v:
Journal of Medicinal Chemistry. 65:13052-13073
Addressing resistance to third-generation EGFR TKIs such as osimertinib via the EGFR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74efbfc9bf49e264df4c98794327c038
https://doi.org/10.1021/acs.jmedchem.2c00893
https://doi.org/10.1021/acs.jmedchem.2c00893
Autor:
Piergiorgio Pettazzoni, James R. Bischoff, Bruno Martoglio, Gabriel Schnetzler, Mitchell P. Levesque, Reinhard Dummer, David S. Hewings, Alessandro Brigo, Marina Bacac, Alison Ribeiro, Dominik Rüttinger, Daniela Krummenacher, Daniel Hunziker, Nicolas Frances, Frank Herting, Jan Eckmann, Jasmin Emmenegger, Cornelia Handl, Martin Kornacker, Jeannine Petrig-Schaffland, Thomas Friess, Caroline Rynn, Jürgen Wichmann
Purpose:Disease progression in BRAF V600E/K positive melanomas to approved BRAF/MEK inhibitor therapies is associated with the development of resistance mediated by RAF dimer inducing mechanisms. Moreover, progressing disease after BRAFi/MEKi frequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2843c44991336c397978b9069d4f8bb4
https://doi.org/10.1158/1078-0432.c.6531080.v1
https://doi.org/10.1158/1078-0432.c.6531080.v1
Autor:
Piergiorgio Pettazzoni, James R. Bischoff, Bruno Martoglio, Gabriel Schnetzler, Mitchell P. Levesque, Reinhard Dummer, David S. Hewings, Alessandro Brigo, Marina Bacac, Alison Ribeiro, Dominik Rüttinger, Daniela Krummenacher, Daniel Hunziker, Nicolas Frances, Frank Herting, Jan Eckmann, Jasmin Emmenegger, Cornelia Handl, Martin Kornacker, Jeannine Petrig-Schaffland, Thomas Friess, Caroline Rynn, Jürgen Wichmann
Supplementary Data from Preclinical Characterization of a Next-Generation Brain Permeable, Paradox Breaker BRAF Inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13025a5f335ff95cafd17d5c42454b84
https://doi.org/10.1158/1078-0432.22483133
https://doi.org/10.1158/1078-0432.22483133
Autor:
Piergiorgio Pettazzoni, James R. Bischoff, Bruno Martoglio, Gabriel Schnetzler, Mitchell P. Levesque, Reinhard Dummer, David S. Hewings, Alessandro Brigo, Marina Bacac, Alison Ribeiro, Dominik Rüttinger, Daniela Krummenacher, Daniel Hunziker, Nicolas Frances, Frank Herting, Jan Eckmann, Jasmin Emmenegger, Cornelia Handl, Martin Kornacker, Jeannine Petrig-Schaffland, Thomas Friess, Caroline Rynn, Jürgen Wichmann
Supplementary Table from Preclinical Characterization of a Next-Generation Brain Permeable, Paradox Breaker BRAF Inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cebd716c1003033988969a2d1ed6815
https://doi.org/10.1158/1078-0432.22483118
https://doi.org/10.1158/1078-0432.22483118
Autor:
Gabriel Schnetzler, Alison Ribeiro, Daniela Krummenacher, Caroline Rynn, Alessandro Brigo, Cornelia Handl, Jasmin Emmenegger, Mitchell P. Levesque, Reinhard Dummer, Nicolas Frances, Daniel Hunziker, Bruno Martoglio, Thomas Friess, Martin Kornacker, Jürgen Wichmann, Dominik Rüttinger, David S. Hewings, Jan Eckmann, Piergiorgio Pettazzoni, Jeannine Petrig-Schaffland, James R. Bischoff, Marina Bacac, Frank Herting
Purpose: Disease progression in BRAF V600E/K positive melanomas to approved BRAF/MEK inhibitor therapies is associated with the development of resistance mediated by RAF dimer inducing mechanisms. Moreover, progressing disease after BRAFi/MEKi freque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::221a5401152655dfeb8a4a7630ad3143
https://www.zora.uzh.ch/id/eprint/218288/
https://www.zora.uzh.ch/id/eprint/218288/
Autor:
Eva Altmann, Paul Erbel, Martin Renatus, Michael Schaefer, Anita Schlierf, Adelaide Druet, Laurence Kieffer, Mickael Sorge, Keith Pfister, Ulrich Hassiepen, Matthew Jones, Simon Ruedisser, Daniela Ostermeier, Bruno Martoglio, Anne B. Jefferson, Jean Quancard
Publikováno v:
Angewandte Chemie. 129:1314-1317
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::163cb1ecf2b637f4dfbede7a42685a9b
https://doi.org/10.1002/ange.201608672
https://doi.org/10.1002/ange.201608672
Autor:
Filip Roudnicky, Marco Berrera, James R. Bischoff, Piergiorgio Pettazzoni, Alice Julien-Laferriere, Tony Kam-Thong, Philipp Ottis, Chiara Palladino, Bruno Martoglio, Phillip Thienger, Adrian Britschgi, Christian Heichinger
Publikováno v:
ACS chemical biology. 14(10)
Proteolysis targeting chimeras are bifunctional small molecules capable of recruiting a target protein of interest to an E3 ubiquitin ligase that facilitates target ubiquitination followed by proteasome-mediated degradation. The first molecules actin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660db212947c63d9c88d731c655f7f17
https://pubmed.ncbi.nlm.nih.gov/31553577
https://pubmed.ncbi.nlm.nih.gov/31553577
Autor:
Bruno Martoglio, Michael Young, Sherry Niessen, Petra Langerak, Michael P. Cooke, Daniel R. Beisner, Carol Dahlberg, S. Sutton, Benjamin F. Cravatt, Albert E. Parker, Ursula Bodendorf, Tim Wiltshire, Whitney Barnes, Francella Otero, Laurent Poirot
Publikováno v:
The Journal of Experimental Medicine
The protease Sppl2a cleaves the N-terminal fragment of invariant chain (CD74) and is required for efficient B cell development and function.
B cell development requires tight regulation to allow for the generation of a diverse repertoire while p
B cell development requires tight regulation to allow for the generation of a diverse repertoire while p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db8cd2a3df60b5f6449a15af6a4194a
http://europepmc.org/articles/PMC3549714
http://europepmc.org/articles/PMC3549714
Autor:
Martin Renatus, Jean Quancard, Matthew Jones, Eva Altmann, Christian Wiesmann, Anita Schlierf, Michael Kiffe, Bruno Martoglio, Anne B. Jefferson, Rene Assenberg, Andreas Weiss, Richard Sedrani, Jörg Eder, Michael Schaefer, Ulrich Hassiepen
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communications
Nature Communications
The COP9 signalosome (CSN) is a central component of the activation and remodelling cycle of cullin-RING E3 ubiquitin ligases (CRLs), the largest enzyme family of the ubiquitin–proteasome system in humans. CRLs are implicated in the regulation of n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac765a53dc1eb9653ac72145e51e58c1
https://doi.org/10.1038/ncomms13166
https://doi.org/10.1038/ncomms13166