Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Bruno M. F. Gonçalves"'
Publikováno v:
Molecules, Vol 25, Iss 15, p 3364 (2020)
Multidrug resistance (MDR) in cancer is one of the main limitations for chemotherapy success. Numerous mechanisms are behind the MDR phenomenon wherein the overexpression of the ATP-binding cassette (ABC) transporter proteins P-glycoprotein (P-gp), b
Externí odkaz:
https://doaj.org/article/ae040a4ad0d0428092afc26c68f7290d
Publikováno v:
RSC Medicinal Chemistry. 14:313-331
Arjunolic acid derivatives containing a pentameric A-ring were prepared. The biological activity on the viability of human cancer and non-tumor cell lines was evaluated as well as the molecular mechanism of action in PANC-1 cells for compound 26.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3487be9c3ed3b3a40c8345c8090327d
https://doi.org/10.1039/d2md00275b
https://doi.org/10.1039/d2md00275b
Autor:
Rafael F. A. Gomes, Bruno M. F. Gonçalves, Késsia H. S. Andrade, Bárbara B. Sousa, Nuno Maulide, Gonçalo J. L. Bernardes, Carlos A. M. Afonso
The demand for new biomass‐derived fine and commodity chemicals propels the discovery of new methodologies and synthons. Whereas furfural and 5‐hydroxymethylfurfural are cornerstones of sustainable chemistry, 3‐acetamido‐5‐acetyl furan (3A5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78972687fcdaf4a682210cff10216d9e
https://www.repository.cam.ac.uk/handle/1810/350505
https://www.repository.cam.ac.uk/handle/1810/350505
Publikováno v:
European Journal of Medicinal Chemistry. 114:101-117
A series of novel fluorinated Asiatic Acid (AA) derivatives were successfully synthesized, tested for their antiproliferative activity against HeLa and HT-29 cell lines, and their structure activity relationships were evaluated. The great majority of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc9303a340c5434245851bba133ac44
https://doi.org/10.1016/j.ejmech.2016.02.057
https://doi.org/10.1016/j.ejmech.2016.02.057
Publikováno v:
Molecules
Molecules, Vol 25, Iss 3364, p 3364 (2020)
Molecules, Vol 25, Iss 3364, p 3364 (2020)
Multidrug resistance (MDR) in cancer is one of the main limitations for chemotherapy success. Numerous mechanisms are behind the MDR phenomenon wherein the overexpression of the ATP-binding cassette (ABC) transporter proteins P-glycoprotein (P-gp), b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d127c8256df9ae1949a3e47d5446e300
https://doi.org/10.3390/molecules25153364
https://doi.org/10.3390/molecules25153364
Publikováno v:
RSC Adv.. 6:39296-39309
A series of new asiatic acid derivatives modified in the A-ring and at C-28 were synthesized and their antiproliferative activity was evaluated against HT-29 and HeLa cell lines. Most of the derivatives tested here exhibited improved antiproliferativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::567b40ab70a14fafab6aecd5db3292f3
https://doi.org/10.1039/c6ra04597a
https://doi.org/10.1039/c6ra04597a
Publikováno v:
RSC Advances. 6:3967-3985
Asiatic acid (AA) is a pentacyclic triterpenoid with recognized anticancer properties. Structural modification of AA may afford derivatives with improved anticancer potency. Hence, in this paper, a series of new lactol and A-nor AA derivatives were p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46c5a5419b80fa89064dd055e85b8951
https://doi.org/10.1039/c5ra19120c
https://doi.org/10.1039/c5ra19120c
Autor:
Jorge A. R. Salvador, Ana S. Leal, Daniela P.S. Alho, Ana S. C. Valdeira, Yongkui Jing, Vanessa I.S. Mendes, Bruno M. F. Gonçalves
Pentacyclic triterpenoids comprise a largest class of natural products, bearing several biological activities, among them anticancer activity. This chapter strolls through the antitumor properties of betulin, betulinic acid, oleanolic acid, glycyrrhe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3beaca3c715562aaf1a59f7ab0de1bc4
https://doi.org/10.1016/b978-0-444-63294-4.00002-4
https://doi.org/10.1016/b978-0-444-63294-4.00002-4
Publikováno v:
Natural product reports. 29(12)
Covering: up to December 2011 This review highlights the potential of natural and semisynthetic ursane-type triterpenoids as candidates for the design of multi-target bioactive compounds, with focus on their anticancer effects. A brief illustration o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d4a2c7a1a12326f695a4009f675503
https://pubmed.ncbi.nlm.nih.gov/23047641
https://pubmed.ncbi.nlm.nih.gov/23047641