Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Bruno M. Costa"'
Autor:
Maria L. Castro-Ribeiro, Vânia I. B. Castro, Joana Vieira de Castro, Ricardo A. Pires, Rui L. Reis, Bruno M. Costa, Helena Ferreira, Nuno M. Neves
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4910 (2024)
Glioblastoma (GBM) is the most lethal and common malignant primary brain tumor in adults. An important feature that supports GBM aggressiveness is the unique composition of its extracellular matrix (ECM). Particularly, fibronectin plays an important
Externí odkaz:
https://doaj.org/article/f5a8dc1b5dcc469c9fe98a8e8be78a66
Autor:
Eduarda P. Martins, Céline S. Gonçalves, Marta Pojo, Rita Carvalho, Ana S. Ribeiro, Vera Miranda‐Gonçalves, Ricardo Taipa, Fernando Pardal, Afonso A. Pinto, Carlos Custódia, Cláudia C. Faria, Fátima Baltazar, Nuno Sousa, Joana Paredes, Bruno M. Costa
Publikováno v:
Molecular Oncology, Vol 16, Iss 14, Pp 2611-2631 (2022)
Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults. The prognosis of patients is very poor, with a median overall survival of ~ 15 months after diagnosis. Cadherin‐3 (also known as P‐cadherin), a cell–cell adhesio
Externí odkaz:
https://doaj.org/article/226b5a08c45b46729dda3b5a0bc6f9c5
Autor:
Elisa Le Boiteux, Franck Court, Pierre‐Olivier Guichet, Catherine Vaurs‐Barrière, Isabelle Vaillant, Emmanuel Chautard, Pierre Verrelle, Bruno M. Costa, Lucie Karayan‐Tapon, Anne Fogli, Philippe Arnaud
Publikováno v:
Molecular Oncology, Vol 15, Iss 8, Pp 1995-2010 (2021)
In human, the 39 coding HOX genes and 18 referenced noncoding antisense transcripts are arranged in four genomic clusters named HOXA, B, C, and D. This highly conserved family belongs to the homeobox class of genes that encode transcription factors r
Externí odkaz:
https://doaj.org/article/fed95548f2564556b60979aca372b0ee
Autor:
Marta Lopes, Joana Vieira de Castro, Marta Pojo, Céline S. Gonçalves, Eduarda P. Martins, Bárbara Coimbra, Ioannis Sotiropoulos, Nuno Sousa, Ana João Rodrigues, Bruno M. Costa
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The existence of a clear association between stress and cancer is still a matter of debate. Recent studies suggest that chronic stress is associated with some cancer types and may influence tumor initiation and patient prognosis, but its role in brai
Externí odkaz:
https://doaj.org/article/6aa6260002fb44b484643f2a66a3ffbb
Autor:
Gonçalo Outeiro-Pinho, Daniela Barros-Silva, Elena Aznar, Ana-Isabel Sousa, Márcia Vieira-Coimbra, Jorge Oliveira, Céline S. Gonçalves, Bruno M. Costa, Kerstin Junker, Rui Henrique, Carmen Jerónimo
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-11 (2020)
Abstract Background The rising incidence of renal cell carcinomas (RCC) constitutes a significant challenge owing to risk of overtreatment. Because aberrant microRNA (miR) promoter methylation contributes to cancer development, we investigated whethe
Externí odkaz:
https://doaj.org/article/d93ad9e825c645bba7841b34f060866f
Autor:
Céline S. Gonçalves, Ana Xavier‐Magalhães, Eduarda P. Martins, Afonso A. Pinto, Manuel Melo Pires, Célia Pinheiro, Rui M. Reis, Nuno Sousa, Bruno M. Costa
Publikováno v:
Molecular Oncology, Vol 14, Iss 6, Pp 1224-1241 (2020)
Despite much effort to improve treatments, patients with malignant glioma still present a very poor prognosis that has not changed significantly in the last decades. In this context, it is crucial to better understand glioma pathogenesis to identify
Externí odkaz:
https://doaj.org/article/fa74f01d1f1e42508e145bf7796c505e
Autor:
Helena Estevão-Pereira, João Lobo, Sofia Salta, Maria Amorim, Paula Lopes, Mariana Cantante, Berta Reis, Luís Antunes, Fernando Castro, Susana Palma de Sousa, Céline S. Gonçalves, Bruno M. Costa, Rui Henrique, Carmen Jerónimo
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-10 (2019)
Abstract Background Breast cancer (BrC) remains the leading cause of cancer-related death in women, mainly due to recurrent and/or metastatic events, entailing the need for biomarkers predictive of progression to advanced disease. MicroRNAs hold prom
Externí odkaz:
https://doaj.org/article/bfef7ff885f6487c9c2f699854450919
Autor:
Gonçalo Outeiro-Pinho, Daniela Barros-Silva, Elena Aznar, Ana-Isabel Sousa, Márcia Vieira-Coimbra, Jorge Oliveira, Céline S. Gonçalves, Bruno M. Costa, Kerstin Junker, Rui Henrique, Carmen Jerónimo
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/51524b231cb0495395c9874d49586bcf
Autor:
João Ramalho-Carvalho, Céline S. Gonçalves, Inês Graça, David Bidarra, Eva Pereira-Silva, Sofia Salta, Maria Inês Godinho, Antonio Gomez, Manel Esteller, Bruno M. Costa, Rui Henrique, Carmen Jerónimo
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-15 (2018)
Abstract Background Prostate cancer (PCa) is a major cause of morbidity and mortality in men worldwide. MicroRNAs are globally downregulated in PCa, especially in poorly differentiated tumors. Nonetheless, the underlying mechanisms are still elusive.
Externí odkaz:
https://doaj.org/article/45e932ad53db42e8bf0de752ceacf8e5
Autor:
Maria João Ferreira, Ana Sílvia Pires-Luís, Márcia Vieira-Coimbra, Pedro Costa-Pinheiro, Luís Antunes, Paula C. Dias, Francisco Lobo, Jorge Oliveira, Céline S. Gonçalves, Bruno M. Costa, Rui Henrique, Carmen Jerónimo
Publikováno v:
Epigenetics, Vol 12, Iss 12, Pp 1057-1064 (2017)
Increasing detection of small renal masses by imaging techniques entails the need for accurate discrimination between benign and malignant renal cell tumors (RCTs) as well as among malignant RCTs, owing to differential risk of progression through met
Externí odkaz:
https://doaj.org/article/61cf888f86114b478bbb870ca14ab91e