Zobrazeno 1 - 10
of 448
pro vyhledávání: '"Bruno Lomonte"'
Autor:
Christoffer V. Sørensen, Julián Fernández, Anna Christina Adams, Helen H. K. Wildenauer, Sanne Schoffelen, Line Ledsgaard, Manuela B. Pucca, Michael Fiebig, Felipe A. Cerni, Tulika Tulika, Bjørn G. Voldborg, Aneesh Karatt-Vellatt, J. Preben Morth, Anne Ljungars, Lise M. Grav, Bruno Lomonte, Andreas H. Laustsen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Improved therapies are needed against snakebite envenoming, which kills and permanently disables thousands of people each year. Recently developed neutralizing monoclonal antibodies against several snake toxins have shown promise in preclini
Externí odkaz:
https://doaj.org/article/99301d927d1f464bb9fbaf12412f986c
Autor:
Cecilia Díaz, Bruno Lomonte, Arturo Chang-Castillo, Fabián Bonilla, Adriana Alfaro-Chinchilla, Felipe Triana, Diego Angulo, Julián Fernández, Mahmood Sasa
Publikováno v:
Toxins, Vol 16, Iss 8, p 327 (2024)
Ananteris is a scorpion genus that inhabits dry and seasonal areas of South and Central America. It is located in a distinctive morpho-group of Buthids, the ‘Ananteris group’, which also includes species distributed in the Old World. Because of t
Externí odkaz:
https://doaj.org/article/94c97e8131854daa844a1dfe98bc0b95
Autor:
Francisco C. P. Coimbra, Elda E. Sanchez, Bruno Lomonte, José María Gutiérrez, Juan J. Calvete, Bryan G. Fry
Publikováno v:
Toxins, Vol 16, Iss 7, p 291 (2024)
This study investigated the intraspecific and interspecific variability in the venom effects of Agkistrodon viperid snake species and subspecies (eleven venoms total) on plasma clotting times, fibrinogen levels, and fibrin clot strength. Significant
Externí odkaz:
https://doaj.org/article/d11216eff6d3468cac8f3afc91554759
Autor:
Line Ledsgaard, Jack Wade, Timothy P. Jenkins, Kim Boddum, Irina Oganesyan, Julian A. Harrison, Pedro Villar, Rachael A. Leah, Renato Zenobi, Sanne Schoffelen, Bjørn Voldborg, Anne Ljungars, John McCafferty, Bruno Lomonte, José M. Gutiérrez, Andreas H. Laustsen, Aneesh Karatt-Vellatt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
The treatment of snakebite envenoming is currently suboptimal. Existing antivenoms often lack efficacy and may cause adverse reactions. Here, the authors derive, develop, and demonstrate the utility of toxin-specific broadly-neutralizing human monocl
Externí odkaz:
https://doaj.org/article/e25513bb2bca42949088d83d90b24bca
Autor:
Gabriela Hernández-Mora, Carlos Chacón-Díaz, Andres Moreira-Soto, Osvaldo Barrantes-Granados, Marcela Suárez-Esquivel, Eunice Viquez-Ruiz, Elías Barquero-Calvo, Nazareth Ruiz-Villalobos, Daniela Hidalgo-Montealegre, Rocío González-Barrientos, Elena A. Demeter, Josimar Estrella-Morales, Ana-Mariel Zúñiga-Pereira, Carlos Quesada-Gómez, Esteban Chaves-Olarte, Bruno Lomonte, Caterina Guzmán-Verri, Jan Felix Drexler, Edgardo Moreno
Publikováno v:
mSphere, Vol 8, Iss 4 (2023)
ABSTRACT Desmodus rotundus, vampire bats, transmit dangerous infections, and brucellosis is a hazardous zoonotic disease, two adversities that coexist in the subtropical and tropical areas of the American continent. Here, we report a 47.89% Brucella
Externí odkaz:
https://doaj.org/article/8c7929c3175848a7b3aa62614bf02621
Autor:
Jorge L. Arias-Arias, Silvia E. Molina-Castro, Laura Monturiol-Gross, Bruno Lomonte, Eugenia Corrales-Aguilar
Publikováno v:
Biotechnology Reports, Vol 37, Iss , Pp e00780- (2023)
SARS-CoV-2 receptor binding domain (RBD) recognizes the angiotensin converting enzyme 2 (ACE2) receptor in host cells that enables infection. Due to its antigenic specificity, RBD production is important for development of serological assays. Here we
Externí odkaz:
https://doaj.org/article/80d57d82a96d4ee9892f469a2acfd3a0
Autor:
Line Ledsgaard, Andreas H. Laustsen, Urska Pus, Jack Wade, Pedro Villar, Kim Boddum, Peter Slavny, Edward W. Masters, Ana S. Arias, Saioa Oscoz, Daniel T. Griffiths, Alice M. Luther, Majken Lindholm, Rachael A. Leah, Marie Sofie Møller, Hanif Ali, John McCafferty, Bruno Lomonte, José M. Gutiérrez, Aneesh Karatt-Vellatt
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
The monocled cobra (Naja kaouthia) is among the most feared snakes in Southeast Asia due to its toxicity, which is predominantly derived from long-chain α-neurotoxins. The only specific treatment for snakebite envenoming is antivenom based on animal
Externí odkaz:
https://doaj.org/article/70f1a474177c4cbfa84ee8f3a96868e8
Autor:
Alfredo Jesús López-Dávila, Natalie Weber, Theresia Kraft, Faramarz Matinmehr, Mariela Arias-Hidalgo, Julián Fernández, Bruno Lomonte, José María Gutiérrez
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Viperid snake venoms contain a unique family of cytotoxic proteins, the Lys49 PLA2 homologs, which are devoid of enzymatic activity but disrupt the integrity of cell membranes. They are known to induce skeletal muscle damage and are therefor
Externí odkaz:
https://doaj.org/article/cc35569f21c0463fa051d26b773f6b04
Autor:
Gianni Mena, Stephanie Chaves-Araya, Johelen Chacón, Enikő Török, Ferenc Török, Fabián Bonilla, Mahmood Sasa, José María Gutiérrez, Bruno Lomonte, Julián Fernández
Publikováno v:
Toxicon: X, Vol 13, Iss , Pp 100097- (2022)
Coralsnakes belong to the family Elapidae and possess venoms which are lethal to humans and can be grouped based on the predominance of either three finger toxins (3FTxs) or phospholipases A2 (PLA2s). A proteomic and toxicological analysis of the ven
Externí odkaz:
https://doaj.org/article/2ff79ac6469e4a1c9d80ddcdc38ce9a1
Autor:
Barbara S. Soares, Surza Lucia G. Rocha, Viviane A. Bastos, Diogo B. Lima, Paulo C. Carvalho, Fabio C. Gozzo, Borries Demeler, Tayler L. Williams, Janelle Arnold, Amy Henrickson, Thomas J. D. Jørgensen, Tatiana A. C. B. Souza, Jonas Perales, Richard H. Valente, Bruno Lomonte, Francisco Gomes-Neto, Ana Gisele C. Neves-Ferreira
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2022)
DM64 is a toxin-neutralizing serum glycoprotein isolated from Didelphis aurita, an ophiophagous marsupial naturally resistant to snake envenomation. This 64 kDa antitoxin targets myotoxic phospholipases A2, which account for most local tissue damage
Externí odkaz:
https://doaj.org/article/d2f51dc524774961858c41c23f7b897f