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pro vyhledávání: '"Bruno L. Timm"'
Autor:
Marílvia Dansa-Petretski, Renata Stiebler, Juliana B. R. Correa Soares, Marcus F. Oliveira, José R. Silva, Bruno L. Timm, Flávia Borges Mury
Publikováno v:
Journal of Bioenergetics and Biomembranes. 43:93-99
Blood-feeding organisms digest hemoglobin, releasing large quantities of heme inside their digestive tracts. Free heme is very toxic, and these organisms have evolved several mechanisms to protect against its deleterious effects. One of these adaptat
Autor:
Renata Stiebler, G. R. Hearne, Pedro L. Oliveira, Bruno L. Timm, Marcus F. Oliveira, Timothy J. Egan
Publikováno v:
Insect biochemistry and molecular biology. 40(3)
Triatomine insects are obligatory blood-feeders that detoxify most of the hemoglobin-derived heme through its crystallization into hemozoin (Hz). Previous evidence demonstrates the key role of midgut perimicrovillar membranes (PMVM) on heme crystalli
Autor:
Ednildo A. Machado, Marílvia Dansa-Petretski, Marco Antonio de Oliveira, N.V. Vugman, Márcia Attias, Marcus F. Oliveira, Pedro L. Oliveira, Kildare Miranda, Bruno L. Timm, Nelson M. Pinhal, Wanderley de Souza, José R. Silva, João José Fernandes de Sousa
Publikováno v:
FEBS Letters. (1-3):139-144
Haemozoin (Hz) is a haem aggregate produced in some blood-feeding organisms. There is a general belief that Hz formation would be a protective mechanism against haem toxicity. Here we show that when aggregated into Hz, haem is less deleterious than i