Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Bruno L. Oliveira"'
Autor:
Barbara Bernardim, Pedro M.S.D. Cal, Maria J. Matos, Bruno L. Oliveira, Nuria Martínez-Sáez, Inês S. Albuquerque, Elizabeth Perkins, Francisco Corzana, Antonio C.B. Burtoloso, Gonzalo Jiménez-Osés, Gonçalo J. L. Bernardes
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Current cysteine bioconjugation strategies for protein-drug conjugates synthesis often yield heterogeneous and poorly stable products. Here, the authors use carbonylacrylic derivatives to selectively modify cysteine residues and synthesize biological
Externí odkaz:
https://doaj.org/article/c0d7ebdccc9c4ce596735356cd570e4c
Autor:
Bruno L. Oliveira, Rodrigo M. Souza, Jorge P. Silva Filho, Levy C. Gomes, Luiz F. Loureiro Fernandes
Publikováno v:
Neotropical Ichthyology, Vol 16, Iss 1 (2018)
ABSTRACT The objective of this study was to evaluate stress responses in dog snapper (Lutjanus jocu) during transport by evaluating their hematological and biochemical responses. Twenty-five wild dog snapper specimens were used in the experiment (220
Externí odkaz:
https://doaj.org/article/d67e4034541141dd8fb2588637032299
Autor:
Bruno L. Oliveira, Luiz F. Loureiro Fernandes, Adalto Bianchini, Adriana R. Chippari-Gomes, Bruno F. Silva, Geisamanda P. Brandão, Levy C. Gomes
Publikováno v:
Neotropical Ichthyology, Vol 12, Iss 4, Pp 845-852
Three experiments were designed to assess the accumulation and acute toxicity of copper (Cu) in juvenile fat snook Centropomusparallelus. The first experiment was performed to determine the 96-h lethal concentration (LC50) of Cu. The second experimen
Externí odkaz:
https://doaj.org/article/ad6dc319d0304ac48382182108a0a9ba
Autor:
Gean M. Dal Forno, Eloah Latocheski, Ana Beatriz Machado, Julie Becher, Lavinia Dunsmore, Albert L. St. John, Bruno L. Oliveira, Claudio D. Navo, Gonzalo Jiménez-Osés, Rita Fior, Josiel B. Domingos, Gonçalo J. L. Bernardes
Publikováno v:
Journal of the American Chemical Society. 145:10790-10799
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84fcbf451cd8d4e7ce5913085279f2fe
https://doi.org/10.1021/jacs.3c01960
https://doi.org/10.1021/jacs.3c01960
Autor:
Pedro M. S. D. Cal, He Li, Gonzalo Jiménez-Osés, Claudio D. Navo, Zbigniew Zawada, Francisco Corzana, Zijian Guo, Bruno L. Oliveira, Gonçalo J. L. Bernardes
Publikováno v:
Bioconjugate Chemistry
Strained alkenes and alkynes are the predominant dienophiles used in inverse electron demand Diels–Alder (IEDDA) reactions. However, their instability, cross-reactivity, and accessibility are problematic. Unstrained dienophiles, although physiologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d795a4e489e54edb4ad69b9472b156e5
https://doi.org/10.1021/acs.bioconjchem.1c00276
https://doi.org/10.1021/acs.bioconjchem.1c00276
Autor:
Gean M Dal Forno, Gonçalo J. L. Bernardes, Thuany M. Ferreira, Josiel B. Domingos, Bruno L. Oliveira, Eloah Latocheski
Publikováno v:
Chemical Society Reviews. 49:7710-7729
Cleavage of C-O and C-N bonds mediated by transition metals is a promising bioorthogonal approach to rescue the activity of caged molecules, such as proteins and cytotoxic drugs, under biological conditions. However, the precise mechanism of such unc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0149d6151e1bcf3f5bd39725043c46ed
https://doi.org/10.1039/d0cs00630k
https://doi.org/10.1039/d0cs00630k
Autor:
Justin M. Chalker, Michael J. Deery, Lisa J Alcock, Michael V. Perkins, Bruno L. Oliveira, Gonçalo J. L. Bernardes, Tara L. Pukala
Publikováno v:
ACS Chemical Biology. 14:594-598
Norbornene derivatives were validated as probes for cysteine sulfenic acid on proteins and in live cells. Trapping sulfenic acids with norbornene probes is highly selective and revealed a different reactivity profile than the traditional dimedone rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82aab1c3d4c788addf6a7fd1faef659f
https://doi.org/10.1021/acschembio.8b01104
https://doi.org/10.1021/acschembio.8b01104
Publikováno v:
Nature Reviews Chemistry. 3:147-171
Proteins constitute the majority of nature’s worker biomolecules. Designed for specific functions, complex tertiary structures make proteins ideal candidates for analysing natural systems and creating novel biological tools. Owing to both their lar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4abf821ee70d335d4f4ded960655b89b
https://doi.org/10.1038/s41570-019-0079-1
https://doi.org/10.1038/s41570-019-0079-1
Publikováno v:
Organic & Biomolecular Chemistry. 17:5725-5730
Bioorthogonal decaging reactions are a promising strategy for prodrug activation because they involve bond cleavage to release a molecule of interest. The trans-cyclooctene (TCO)-tetrazine inverse electron-demand Diels-Alder reaction has been widely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313ccc1f831f392652453a7c9e62bc4e
https://doi.org/10.1039/c9ob01167f
https://doi.org/10.1039/c9ob01167f
Autor:
António Paulo, Gonçalo J. L. Bernardes, Filipa Mendes, Bruno L. Oliveira, Lurdes Gano, Vera F. C. Ferreira, Carlos M. Farinha, Alice D'Onofrio
Publikováno v:
Bioconjugate Chemistry
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Copyright © 2020 American Chemical Society.
Pretargeted imaging has emerged as an effective multistep strategy aiming to improve imaging contrast and reduce patient radiation exposure through decoupling of the radioactivity from the targeting v
Pretargeted imaging has emerged as an effective multistep strategy aiming to improve imaging contrast and reduce patient radiation exposure through decoupling of the radioactivity from the targeting v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e335ba78daac7c2c611d384ce671ba44