Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Bruno L Cadilha"'
Autor:
Christian Klein, Daria Briukhovetska, Michael von Bergwelt-Baildon, Sebastian Kobold, Mitchell P Levesque, Bruno L Cadilha, Stefan Endres, Mohamed-Reda Benmebarek, Hannah Obeck, Sophia Stock, Florian Märkl, Julius Keyl, Martina Geiger, Clara Karches, Melanie Schwerdtfeger, Stefanos Michaelides, Jakob Jobst, Philipp Jie Müller, Lina Majed, Matthias Seifert, Anna-Kristina Klüver, Theo Lorenzini, Ruth Grünmeier, Moritz Thomas, Adrian Gottschlich, Richard Klaus, Carsten Marr, Simon Rothenfusser, Markus Vincent Heppt
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 5 (2023)
Background Melanoma is an immune sensitive disease, as demonstrated by the activity of immune check point blockade (ICB), but many patients will either not respond or relapse. More recently, tumor infiltrating lymphocyte (TIL) therapy has shown promi
Externí odkaz:
https://doaj.org/article/b199e93aa3494d549053b8485d6551d1
Autor:
Anastasia Prokopi, Christoph H Tripp, Bart Tummers, Florian Hornsteiner, Sarah Spoeck, Jeremy Chase Crawford, Derek R Clements, Mirjana Efremova, Katharina Hutter, Lydia Bellmann, Giuseppe Cappellano, Bruno L Cadilha, Daniela Ortner, Zlatko Trajanoski, Suzie Chen, Juliana Idoyaga, Douglas R Green, Patrizia Stoitzner
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)
Background Immunotherapy with checkpoint inhibitors has shown impressive results in patients with melanoma, but still many do not benefit from this line of treatment. A lack of tumor-infiltrating T cells is a common reason for therapy failure but als
Externí odkaz:
https://doaj.org/article/66831436d29b40f3abee1e0b88929637
Autor:
Gabriela M Wiedemann, Celina Aithal, Angelina Kraechan, Constanze Heise, Bruno L Cadilha, Jin Zhang, Peter Duewell, Robert Ballotti, Stefan Endres, Corine Bertolotto, Sebastian Kobold
Publikováno v:
Translational Oncology, Vol 12, Iss 2, Pp 350-360 (2019)
Microphthalmia-associated transcription factor (MITF) is a key transcription factor in melanoma development and progression. MITF amplification and downregulation have been observed in a significant proportion of melanoma patients and correlate with
Externí odkaz:
https://doaj.org/article/8b808996bad94c3988c55a3d62a6bc68
Autor:
Matthias Seifert, Mohamed-Reda Benmebarek, Daria Briukhovetska, Florian Märkl, Janina Dörr, Bruno L. Cadilha, Jakob Jobst, Sophia Stock, David Andreu-Sanz, Theo Lorenzini, Ruth Grünmeier, Arman Oner, Hannah Obeck, Lina Majed, Dario Dhoqina, Manouk Feinendegen, Adrian Gottschlich, Jin Zhang, Ulrike Schindler, Stefan Endres, Sebastian Kobold
Publikováno v:
Br. J. Cancer 127, 2175-2185 (2022)
Background Chimeric antigen receptor (CAR) T cell therapy has been successfully translated to clinical practice for the treatment of B cell malignancies. The suppressive microenvironment of many malignancies is a bottleneck preventing treatment succe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19720611772e795eef9a9cf1c79357fc
https://doi.org/10.1038/s41416-022-02013-z
https://doi.org/10.1038/s41416-022-02013-z
Autor:
Sebastian Kobold, Christian Klein, Stefan Endres, Claudio Sustmann, Gerhard Niederfellner, Peter Duewell, Jian Ding, Daniel Lamp, Martin Jastroch, Johannes vom Berg, Ramona Murr, Constanze Heise, Stefanie Lesch, Bruno L. Cadilha, Felicitas Rataj, Martina Geiger, Richard Klaus, Mathias Kurzay, Moritz L. Schmidbauer, Mohamed-Reda Benmebarek, Clara H. Karches
Supplementary figure legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e7cab8c4b1704040ae3615668f1f8d8
https://doi.org/10.1158/1078-0432.22474295
https://doi.org/10.1158/1078-0432.22474295
Autor:
Sebastian Kobold, Christian Klein, Stefan Endres, Claudio Sustmann, Gerhard Niederfellner, Peter Duewell, Jian Ding, Daniel Lamp, Martin Jastroch, Johannes vom Berg, Ramona Murr, Constanze Heise, Stefanie Lesch, Bruno L. Cadilha, Felicitas Rataj, Martina Geiger, Richard Klaus, Mathias Kurzay, Moritz L. Schmidbauer, Mohamed-Reda Benmebarek, Clara H. Karches
Supplementary Figure 1: Murine SAR expression and immunophenotyping of transduced T cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a90233c4261d80a62920c94e17bf00c1
https://doi.org/10.1158/1078-0432.22474316
https://doi.org/10.1158/1078-0432.22474316
Autor:
Sebastian Kobold, Christian Klein, Stefan Endres, Claudio Sustmann, Gerhard Niederfellner, Peter Duewell, Jian Ding, Daniel Lamp, Martin Jastroch, Johannes vom Berg, Ramona Murr, Constanze Heise, Stefanie Lesch, Bruno L. Cadilha, Felicitas Rataj, Martina Geiger, Richard Klaus, Mathias Kurzay, Moritz L. Schmidbauer, Mohamed-Reda Benmebarek, Clara H. Karches
Supplementary Figure 5: Effect of pre-activated SAR T cells on hepatocellular carcinoma and glioblastoma cells

Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb8f62c994f09916a24e2860d1dc00a4
https://doi.org/10.1158/1078-0432.22474301
https://doi.org/10.1158/1078-0432.22474301
Autor:
Sebastian Kobold, Christian Klein, Stefan Endres, Claudio Sustmann, Gerhard Niederfellner, Peter Duewell, Jian Ding, Daniel Lamp, Martin Jastroch, Johannes vom Berg, Ramona Murr, Constanze Heise, Stefanie Lesch, Bruno L. Cadilha, Felicitas Rataj, Martina Geiger, Richard Klaus, Mathias Kurzay, Moritz L. Schmidbauer, Mohamed-Reda Benmebarek, Clara H. Karches
Purpose:Genetically engineered T cells are powerful anticancer treatments but are limited by safety and specificity issues. We herein describe an MHC-unrestricted modular platform combining autologous T cells, transduced with a targetable synthetic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300bb4fcd831d93ea7ee473442fa12d8
https://doi.org/10.1158/1078-0432.c.6528746
https://doi.org/10.1158/1078-0432.c.6528746
Autor:
Sebastian Kobold, Christian Klein, Stefan Endres, Claudio Sustmann, Gerhard Niederfellner, Peter Duewell, Jian Ding, Daniel Lamp, Martin Jastroch, Johannes vom Berg, Ramona Murr, Constanze Heise, Stefanie Lesch, Bruno L. Cadilha, Felicitas Rataj, Martina Geiger, Richard Klaus, Mathias Kurzay, Moritz L. Schmidbauer, Mohamed-Reda Benmebarek, Clara H. Karches
Supplementary Figure 4: Human SAR T cells are specifically stimulated by anti-human mesothelin x anti-EGFRv3 2 + 1 BiAb and redirect lysis to mesothelin+ target cells in vitro and in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e39997f7c43ba5db9abe24ffdb8d671
https://doi.org/10.1158/1078-0432.22474304.v1
https://doi.org/10.1158/1078-0432.22474304.v1
Autor:
Sebastian Kobold, Christian Klein, Stefan Endres, Claudio Sustmann, Gerhard Niederfellner, Peter Duewell, Jian Ding, Daniel Lamp, Martin Jastroch, Johannes vom Berg, Ramona Murr, Constanze Heise, Stefanie Lesch, Bruno L. Cadilha, Felicitas Rataj, Martina Geiger, Richard Klaus, Mathias Kurzay, Moritz L. Schmidbauer, Mohamed-Reda Benmebarek, Clara H. Karches
Supplementary Figure 3: In contrast to SAR T cells, CAR T cells rely on the release of perforin for efficient killing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e29304fcb6cb1f961c465b22c3f68f
https://doi.org/10.1158/1078-0432.22474310
https://doi.org/10.1158/1078-0432.22474310