Discovery of a haptoglobin glycopeptides biomarker panel for early diagnosis of hepatocellular carcinoma

Autor: Mahdokht Kohansal-Nodehi, Magdalena Swiatek-de Lange, Konstantin Kroeniger, Vinzent Rolny, Glòria Tabarés, Teerha Piratvisuth, Tawesak Tanwandee, Satawat Thongsawat, Wattana Sukeepaisarnjaroen, Juan Ignacio Esteban, Marta Bes, Bruno Köhler, Henry Lik-Yuen Chan, Holger Busskamp

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

BackgroundThere is a need for new serum biomarkers for early detection of hepatocellular carcinoma (HCC). Haptoglobin (Hp) N-glycosylation is altered in HCC, but the diagnostic value of site-specific Hp glycobiomarkers is rarely reported. We aimed to

Externí odkaz: https://doaj.org/article/0d169cb35aaa4f389904f79e35563f63

HER2 gene (ERBB2) amplification is a rare event in non-liver-fluke associated cholangiocarcinogenesis

Autor: Thomas Albrecht, Melina Rausch, Stephanie Rössler, Michael Albrecht, Jana Dorothea Braun, Veronika Geissler, Arianeb Mehrabi, Monika Nadja Vogel, Anita Pathil-Warth, Gunhild Mechtersheimer, Marcus Renner, Christian Rupp, Karl Heinz Weiss, Elena Busch, Bruno Köhler, Christoph Springfeld, Peter Schirmacher, Benjamin Goeppert

Publikováno v: BMC Cancer, Vol 19, Iss 1, Pp 1-9 (2019)

Abstract Background Cholangiocarcinoma is a rapidly fatal cancer entity with a median survival of less than one year. In contrast to many other malignancies, no substantial therapeutic breakthrough has been made in the past few decades, thereby limit

Externí odkaz: https://doaj.org/article/cc00150a8d3246a89bd252ece9686adb

Programmed cell death ligand 1 (PD-L1, CD274) in cholangiocarcinoma – correlation with clinicopathological data and comparison of antibodies

Autor: Mark Kriegsmann, Stephanie Roessler, Katharina Kriegsmann, Marcus Renner, Rémi Longuespée, Thomas Albrecht, Moritz Loeffler, Stephan Singer, Arianeb Mehrabi, Monika Nadja Vogel, Anita Pathil, Bruno Köhler, Christoph Springfeld, Christian Rupp, Karl Heinz Weiss, Benjamin Goeppert

Publikováno v: BMC Cancer, Vol 19, Iss 1, Pp 1-10 (2019)

Abstract Background Cholangiocarcinoma (CCA) may arise in the intra- or extrahepatic biliary tract and is associated with a poor prognosis. Despite recent advances, to date there is still no established targeted therapeutic approach available. Non-su

Externí odkaz: https://doaj.org/article/9d64ab94589b438cbe0b99f4c0bf7dcd

Spatiotemporal analysis of tumour-infiltrating immune cells in biliary carcinogenesis

Autor: Alphonse Charbel, Luca Tavernar, Thomas Albrecht, Fritz Brinkmann, Joanne Verheij, Eva Roos, Monika Nadja Vogel, Bruno Köhler, Christoph Springfeld, Alexander Brobeil, Peter Schirmacher, Stephan Singer, Arianeb Mehrabi, Stephanie Roessler, Benjamin Goeppert

Publikováno v: Charbel, A, Tavernar, L, Albrecht, T, Brinkmann, F, Verheij, J, Roos, E, Vogel, M N, Köhler, B, Springfeld, C, Brobeil, A, Schirmacher, P, Singer, S, Mehrabi, A, Roessler, S & Goeppert, B 2022, ' Spatiotemporal analysis of tumour-infiltrating immune cells in biliary carcinogenesis ', British Journal of Cancer, vol. 127, no. 9, pp. 1603-1614 . https://doi.org/10.1038/s41416-022-01933-0
British journal of cancer, 127(9), 1603-1614. Nature Publishing Group
British Journal of Cancer, 127(9), 1603-1614. Nature Publishing Group

BackgroundIntraductal papillary neoplasms (IPN) and biliary epithelial neoplasia (BilIN) are well‐defined precursor lesions of biliary tract carcinoma (BTC). The aim of this study was to provide a comprehensive characterisation of the inflammatory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe5e5ba1dab998ad087158c97b6e51c7
https://doi.org/10.1055/s-0042-1760022

Comprehensive evaluation of microRNA as a biomarker for the diagnosis of hepatocellular carcinoma

Autor: Juliane Malik, Martin Klammer, Vinzent Rolny, Henry Lik-Yuen Chan, Teerha Piratvisuth, Tawesak Tanwandee, Satawat Thongsawat, Wattana Sukeepaisarnjaroen, Juan Ignacio Esteban, Marta Bes, Bruno Köhler, Magdalena Swiatek-de Lange

Publikováno v: Scientia

Carcinoma; Diagnosis; MicroRNAs Carcinoma; Diagnóstico; MicroARN Carcinoma; Diagnòstic; MicroARN Background: Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Current guidelines for HCC management recommend surveillanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13833daf0c91bb57eed050e2bb5454db
https://pubmed.ncbi.nlm.nih.gov/36157551