Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Bruno Igreja"'
Publikováno v:
Clinical and Experimental Hypertension, Vol 43, Iss 5, Pp 428-435 (2021)
Salt-inducible kinases (SIKs) represent a subfamily of AMPK family kinases. SIK1 has been shown to act as a mediator during the cellular adaptation to variations in intracellular sodium in a variety of cell types. SIK2, as an isoform of the SIK famil
Externí odkaz:
https://doaj.org/article/c5dd2429334345bca42fe373c73e695c
Autor:
Emanuel F Matias, Eduardo Moura, Bruno Igreja, Filipa Lopes Campos, Alejandro M. Bertorello, Tatiana António, Nuno Marques Pires, Maria Paula Serrão, Laura Brion, Patrício Soares-da-Silva
Publikováno v:
Hypertension Research. 42:1114-1124
Loss of salt-inducible kinase 1 (SIK1) triggers an increase in blood pressure (BP) upon a chronic high-salt intake in mice. Here, we further addressed the possible early mechanisms that may relate to the observed rise in BP in mice lacking SIK1. SIK1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8597409352c288487cf73564587a1f09
https://doi.org/10.1038/s41440-019-0249-z
https://doi.org/10.1038/s41440-019-0249-z
Autor:
Tatiana, António, Dina, Cosme, Bruno, Igreja, Sónia, Fraga, Maria Paula, Serrão, Nuno M, Pires, Patrício, Soares-da-Silva
Publikováno v:
European journal of pharmacology. 904
Type 1 salt-inducible kinases (SIK1) has been shown to act as a mediator during the cellular adaptation to variations in intracellular sodium in a variety of cell types. Type 2 SIK (SIK2) modulates various biological functions and acts as a signal tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0f86fe87afdd10b7c5670c261652f78b
https://pubmed.ncbi.nlm.nih.gov/33989615
https://pubmed.ncbi.nlm.nih.gov/33989615
Autor:
Eric Chevalier, Bruno Igreja, Maria-Joao Bonifacio, Luis Magalhaes, Patrício Soares-da-Silva, Nuno Pires
Publikováno v:
Pulmonary hypertension.
Pulmonary arterial hypertension (PAH) is characterized by a progressive increase in pulmonary vascular resistance causing right ventricular failure and premature death. Studies of PAH patients show a hyperstimulation of the sympathetic nervous system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cca508e46a9599845385a55d6edd34ec
https://doi.org/10.1183/13993003.congress-2020.1483
https://doi.org/10.1183/13993003.congress-2020.1483
Autor:
Vânia Batalha, Bruno Igreja, Patrício Soares-da-Silva, Nuno Pires, Maria-Joao Bonifacio, Eduardo Moura, Cristina Costa
Publikováno v:
Pulmonary hypertension.
Pulmonary arterial hypertension (PAH) is a group of rare diseases characterized by elevated pulmonary arterial resistance leading to right ventricle hypertrophy and failure. Studies of PAH patients show that hyperstimulation of the sympathetic nervou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::480f4f664520d773199a043b5b65a803
https://doi.org/10.1183/13993003.congress-2020.3560
https://doi.org/10.1183/13993003.congress-2020.3560
Autor:
Nuno Marques Pires, Eduardo Moura, Maria-Joao Bonifacio, Filipa Sousa, Patrio Soares-da-Silva, Bruno Igreja
Publikováno v:
A57. PULMONARY VASCULAR DISEASES AND RV FUNCTIONS: NOVEL SIGNALLING MECHANISMS, EXCITING MODELS AND EMERGING TREATMENT OPTIONS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75db29368106f75a807a8fa84b002263
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2088
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2088
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] The hyperactivity of the sympathetic nervous system (SNS) plays a major role in the development and progression of several cardiovascular diseases. One strategy to mitigate the SNS overdrive is by restricting the biosynthesis of nor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be5d72383c286b762a9b85fbf31b1bf
https://europepmc.org/articles/PMC7089015/
https://europepmc.org/articles/PMC7089015/
Publikováno v:
European journal of pharmacology. 842
Hyperactivity of sympathetic nervous system plays an important role in the development and progression of cardiovascular diseases. An approach to mitigate the enhanced sympathetic nervous system drive is restricting the biosynthesis of noradrenaline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8488091ccca958ab1ce6a0a3b1a0430f
https://pubmed.ncbi.nlm.nih.gov/30401628
https://pubmed.ncbi.nlm.nih.gov/30401628
Autor:
Nuno Marques, Pires, Bruno, Igreja, Maria Paula, Serrão, Emanuel F, Matias, Eduardo, Moura, Tatiana, António, Filipa Lopes, Campos, Laura, Brion, Alejandro, Bertorello, Patrício, Soares-da-Silva
Publikováno v:
Hypertension research : official journal of the Japanese Society of Hypertension. 42(8)
Loss of salt-inducible kinase 1 (SIK1) triggers an increase in blood pressure (BP) upon a chronic high-salt intake in mice. Here, we further addressed the possible early mechanisms that may relate to the observed rise in BP in mice lacking SIK1. SIK1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::943fe06c57f5fdeb27f0065b9980eefe
https://pubmed.ncbi.nlm.nih.gov/30894696
https://pubmed.ncbi.nlm.nih.gov/30894696
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8392cd6fcf0e829c1e7cca85be47ace2
https://doi.org/10.1096/fasebj.2018.32.1_supplement.688.3
https://doi.org/10.1096/fasebj.2018.32.1_supplement.688.3