Výsledky vyhledávání - "Bruno Hurtrel"

Akademický článek

HIV/SIV infection primes monocytes and dendritic cells for apoptosis.

Autor: Mireille Laforge, Laure Campillo-Gimenez, Valérie Monceaux, Marie-Christine Cumont, Bruno Hurtrel, Jacques Corbeil, John Zaunders, Carole Elbim, Jérôme Estaquier

Publikováno v: PLoS Pathogens, Vol 7, Iss 6, p e1002087 (2011)

Subversion or exacerbation of antigen-presenting cells (APC) death modulates host/pathogen equilibrium. We demonstrated during in vitro differentiation of monocyte-derived macrophages and monocyte-derived dendritic cells (DCs) that HIV sensitizes the

Externí odkaz: https://doaj.org/article/0d9479ce59ce42359ce7cea759fab099

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The anti-caspase inhibitor Q-VD-OPH prevents AIDS disease progression in SIV-infected rhesus macaques

Autor: Guido Silvestri, Julie Garibal, Vasco Rodrigues, Alain Pruvost, Shahul Mouhamad, Mireille Laforge, Valérie Monceaux, Jérôme Estaquier, Anna Senik, Bruno Hurtrel, Henintsoa Rabezanahary, Ricardo Silvestre, Anabela Cordeiro-da-Silva, Laure Campillo-Gimenez, Marie-Christine Cumont

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 2018, 128 (4), pp.1627-1640. ⟨10.1172/JCI95127⟩

Apoptosis has been proposed as a key mechanism responsible for CD4+ T cell depletion and immune dysfunction during HIV infection. We demonstrated that Q-VD-OPH, a caspase inhibitor, inhibits spontaneous and activation-induced death of T cells from SI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a722532b12bdd83ff678a61fe5e8c8
https://europepmc.org/articles/PMC5873886/

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AIDS Progression Is Associated with the Emergence of IL-17–Producing Cells Early After Simian Immunodeficiency Virus Infection

Autor: Marie-Christine Cumont, Hassen Kared, Michaela Müller-Trutwin, Carole Elbim, Valérie Monceaux, Jérôme Estaquier, Ousmane M. Diop, Laure Campillo-Gimenez, John Zaunders, Michèle Fay, Bruno Hurtrel, Maria Leite-de-Moraes, Yves Levy, Michel Dy

Publikováno v: The Journal of Immunology. 184:984-992

IL-17 is a potent effector cytokine involved in inflammatory response and antimicrobial defense. We report that SIV infection of rhesus macaques (RMs) results in the emergence of IL-17–expressing cells during the acute phase. This subpopulation app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f99fb3df0cf576c694ae1b812b943cf
https://doi.org/10.4049/jimmunol.0902316

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TGF-β in intestinal lymphoid organs contributes to the death of armed effector CD8 T cells and is associated with the absence of virus containment in rhesus macaques infected with the simian immunodeficiency virus

Autor: Stephanie Lay, Laurence Viollet, Marie-Christine Cumont, R Parker, Valérie Monceaux, Jérôme Estaquier, Bruno Hurtrel

Publikováno v: Cell Death & Differentiation. 14:1747-1758

SIV-infected macaques exhibit distinct rates of progression to AIDS and despite significant increases in CD8+ T cells, immune cells fail to control and eradicate SIV in vivo. Here, we investigated the interplay between viral reservoir sites, CD8+ T-c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9060f25cbfdc37bbe64e8696d1376fb
https://doi.org/10.1038/sj.cdd.4402192

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Death of CD4+ T Cells from Lymph Nodes during Primary SIVmac251 Infection Predicts the Rate of AIDS Progression

Autor: Valérie Monceaux, Marie-Christine Cumont, Jérôme Estaquier, Raphaël Ho Tsong Fang, Bruno Hurtrel, Frédéric Petit, Laurence Viollet

Publikováno v: The Journal of Immunology. 177:6685-6694

Immunological and virological events that occur during the earliest stages of SIV infection are now considered to have a major impact on subsequent disease progression. In the present study, we demonstrate a clear correlation between progression to A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a56acbbbcd70dd0fc444438c3b240132
https://doi.org/10.4049/jimmunol.177.10.6685

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Antigenic Stimulation Specifically Reactivates the Replication of Archived Simian Immunodeficiency Virus Genomes in Chronically Infected Macaques

Autor: Bruno Hurtrel, Rémi Cheynier, Simon Wain-Hobson, Céline Renoux

Publikováno v: Journal of Virology
Journal of Virology, 2005, 79 (17), pp.11231-8. ⟨10.1128/JVI.79.17.11231-11238.2005⟩
Journal of Virology, American Society for Microbiology, 2005, 79 (17), pp.11231-8. ⟨10.1128/JVI.79.17.11231-11238.2005⟩

Human immunodeficiency virus/simian immunodeficiency virus (SIV) diversification is a direct consequence of viral replication and occurs principally in secondary lymphoid organs where CD4 + T cells are activated and proliferate. However, the evolutio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad69c461c8cf339ca0c973bd575632f
https://doi.org/10.1128/jvi.79.17.11231-11238.2005

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Tat-neutralizing versus Tat-protecting antibodies in rhesus macaques vaccinated with Tat peptides

Autor: Bernard A. P. Lafont, Anne-Marie Aubertin, Guillaume Belliard, Valérie Monceaux, Roger Le Grand, Bruno Hurtrel, Sylviane Muller, Emmanuel Moreau, Bernard P. Roques, Claude Desgranges

Publikováno v: Vaccine. 23:1399-1407

The human immunodeficiency virus (HIV) regulatory protein Tat represents an attractive target for developing vaccine strategies. Both humoral and cellular responses against Tat might reduce disease progression by interfering with the deleterious func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97ed8f2e98d1156788ff6cc42bbe8f68
https://doi.org/10.1016/j.vaccine.2004.08.037

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Early changes in peripheral blood T cells during primary infection of rhesus macaques with a pathogenic SIV

Autor: Valérie Monceaux, Bruno Hurtrel, Anne-Marie Aubertin, Jérôme Estaquier, Jean-Claude Ameisen, Marie-Christine Cumont

Publikováno v: Journal of Medical Primatology. 29:127-135

Primary infection of rhesus macaques with pathogenic strains of simian immunodeficiency virus (SIV) leads to rapid and dynamic changes in both viral load and T cell counts in the peripheral blood. We have performed a sequential analysis of peripheral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13f0f405ae5e6c3dfaea7bcead747d6d
https://doi.org/10.1034/j.1600-0684.2000.290305.x

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A Molecularly Cloned Schwarz Strain of Measles Virus Vaccine Induces Strong Immune Responses in Macaques and Transgenic Mice

Autor: Lucile Mollet, Frédéric Tangy, Harold McClure, Clarisse Lorin, Michel Brahic, Bruno Hurtrel, Chantal Combredet, Mark B. Feinberg, Frédéric Delebecque, Valérie Labrousse

Publikováno v: Journal of Virology
Journal of Virology, 2003, 77 (21), pp.11546-11554. ⟨10.1128/jvi.77.21.11546-11554.2003⟩
Journal of Virology, American Society for Microbiology, 2003, 77 (21), pp.11546-11554. ⟨10.1128/jvi.77.21.11546-11554.2003⟩

Live attenuated RNA viruses make highly efficient vaccines. Among them, measles virus (MV) vaccine has been given to a very large number of children and has been shown to be highly efficacious and safe. Therefore, this vaccine might be a very promisi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5b665deceee2e459470fec8e4e1a34
https://doi.org/10.1128/jvi.77.21.11546-11554.2003

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