Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Bruno Hubesch"'
Autor:
Barbara Birk, Jonathan Crozier, Catrina Stirling, Rob Taalman, Vikas Kumar, Magdalini Sachana, Alicia Paini, Boris P. Müller, Irene Manou, Mario Monshouwer, Federica De Gaetano, Alfonso Lostia, Hans Bender, Bruno Hubesch, Charles Laroche, Kirsty Reid, Iain Gardner, Renate Weissenhorn, Gianni Dal Negro, Timothy Rowan, Paul Benndorf, Ursula G. Sauer, A. Irizar, Leon van Aerts, Christian Desaintes, Katrin Schutte, David John, M. Aggarwal
Publikováno v:
Regulatory Toxicology and Pharmacology
The European Partnership for Alternative Approaches to Animal Testing (EPAA) convened a Partners' Forum Toxicokinetics and Read-Across to provide an overview on research activities to develop in vitro toxicokinetics methods and physiologically-based
Autor:
Kathleen P. Plotzke, Bruno Hubesch, Elisabet Berggren, Robert A. Barter, Océane Albert, Emilio Benfenati, Heli M. Hollnagel, Ursula G. Sauer, Kunifumi Inawaka, Philipp Mayer, Robert Skoglund, Richard A. Becker, Athena M. Keene
Publikováno v:
Sauer, U G, Barter, R A, Becker, R A, Benfenati, E, Berggren, E, Hubesch, B, Hollnagel, H M, Inawaka, K, Keene, A M, Mayer, P, Plotzke, K, Skoglund, R & Albert, O 2020, ' 21 st Century Approaches for Evaluating Exposures, Biological Activity, and Risks of Complex Substances : Workshop highlights ', Regulatory Toxicology and Pharmacology, vol. 111, 104583 . https://doi.org/10.1016/j.yrtph.2020.104583
The June 2019 workshop 21st Century Approaches for Evaluating Exposures, Biological Activity, and Risks of Complex Substances, co-organised by the International Council of Chemical Association's Long-Range Research Initiative and the European Commiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb202031e6a43a386f6ee6a14d8c93b6
https://orbit.dtu.dk/en/publications/e7fb96f5-968d-4d29-a7af-200847cff86b
https://orbit.dtu.dk/en/publications/e7fb96f5-968d-4d29-a7af-200847cff86b
Autor:
Grace Patlewicz, Matthias Herzler, Manuela Pavan, Marcel Leist, Thomas Hartung, Tara S. Barton-Maclaren, Susanne Hougaard Bennekou, Kerry Nugent, Simona Kovarich, Alexandra Maertens, P. Charukeshi Chandrasekera, Bruno Hubesch, Joop de Knecht, Nicole Kleinstreuer, Francesca Caloni, Lena Smirnova, Sylvia Escher, Mark T. D. Cronin, Emilio Benfenati, Giorgia Pallocca, Jaffar Kisitu, Manuel Pastor, Christophe Chesne, Hennicke Kamp, Michael Schwarz, Suzanne Fitzpatrick, Octavio Augusto França Presgrave, Daniel R. Dietrich, Takashi Yamada, Costanza Rovida, Brenna M. Flannery
Publikováno v:
ALTEX
Rovida, C, Barton-Maclaren, T, Benfenati, E, Caloni, F, Chandrasekera, C, Chesne, C, Cronin, M T D, De Knecht, J, Dietrich, D R, Escher, S E, Fitzpatrick, S, Flannery, B, Herzler, M, Hougaard Bennekou, S, Hubesch, B, Kamp, H, Kisitu, J, Kleinstreuer, N, Kovarich, S, Leist, M, Maertens, A, Nugent, K, Pallocca, G, Pastor, M, Patlewicz, G, Pavan, M, Presgrave, O, Smirnova, L, Schwarz, M, Yamada, T & Hartung, T 2020, ' Internationalization of read-across as a validated new approach method (NAM) for regulatory toxicology ', A L T E X. Alternatives to Animal Experimentation, vol. 37, no. 4, pp. 579-606 . https://doi.org/10.14573/altex.1912181
Rovida, C, Barton-Maclaren, T, Benfenati, E, Caloni, F, Chandrasekera, C, Chesne, C, Cronin, M T D, De Knecht, J, Dietrich, D R, Escher, S E, Fitzpatrick, S, Flannery, B, Herzler, M, Hougaard Bennekou, S, Hubesch, B, Kamp, H, Kisitu, J, Kleinstreuer, N, Kovarich, S, Leist, M, Maertens, A, Nugent, K, Pallocca, G, Pastor, M, Patlewicz, G, Pavan, M, Presgrave, O, Smirnova, L, Schwarz, M, Yamada, T & Hartung, T 2020, ' Internationalization of read-across as a validated new approach method (NAM) for regulatory toxicology ', A L T E X. Alternatives to Animal Experimentation, vol. 37, no. 4, pp. 579-606 . https://doi.org/10.14573/altex.1912181
Read-across (RAx) translates available information from well-characterized chemicals tothe substance for which there is a toxicological data gap. The OECD is working on case studies to probe general applicability of RAx, and several regulations (e.g.
Autor:
Marco Corvaro, Janine Ezendam, Peter Griem, Petra S. Kern, Bruno Hubesch, David A. Basketter, Irene Manou, P. Azam, A. Irizar, Laura H. Rossi, Silvia Casati, Annette Mehling
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 109
Four years on since the last cross sector workshop, experience of the practical application and interpretation of several non-animal assays that contribute to the predictive identification of skin sensitisers has begun to accumulate. Non-animal metho
Autor:
Bruno Hubesch, Barbara Birk, Andrea Richarz, Alan R. Boobis, Michael Schwarz, Paul Jennings, Dinant Kroese, Bas J. Blaauboer, Catherine Mahony, Gladys Ouedraogo, Mathieu Vinken, Martina Klaric, Mark T. D. Cronin, Bertrand Desprez, Paul L. Carmichael, Richard Curie, Bob van de Water, Jan van Benthem, Aldert H. Piersma, George P. Daston
Publikováno v:
Toxicology In Vitro, 59, 44-50
59, 44-50
Toxicology in Vitro, 59, 44-50. Elsevier Limited
Desprez, B, Birk, B, Blaauboer, B, Boobis, A, Carmichael, P, Cronin, M T D, Curie, R, Daston, G, Hubesch, B, Jennings, P, Klaric, M, Kroese, D, Mahony, C, Ouédraogo, G, Piersma, A, Richarz, A N, Schwarz, M, van Benthem, J, van de Water, B & Vinken, M 2019, ' A mode-of-action ontology model for safety evaluation of chemicals : Outcome of a series of workshops on repeated dose toxicity ', Toxicology in Vitro, vol. 59, pp. 44-50 . https://doi.org/10.1016/j.tiv.2019.04.005
59, 44-50
Toxicology in Vitro, 59, 44-50. Elsevier Limited
Desprez, B, Birk, B, Blaauboer, B, Boobis, A, Carmichael, P, Cronin, M T D, Curie, R, Daston, G, Hubesch, B, Jennings, P, Klaric, M, Kroese, D, Mahony, C, Ouédraogo, G, Piersma, A, Richarz, A N, Schwarz, M, van Benthem, J, van de Water, B & Vinken, M 2019, ' A mode-of-action ontology model for safety evaluation of chemicals : Outcome of a series of workshops on repeated dose toxicity ', Toxicology in Vitro, vol. 59, pp. 44-50 . https://doi.org/10.1016/j.tiv.2019.04.005
Repeated dose toxicity evaluation aims at assessing the occurrence of adverse effects following chronic or repeated exposure to chemicals. Non-animal approaches have gained importance in the last decades because of ethical considerations as well as d
Autor:
R. Roggeband, Marco Corvaro, Hans Bender, D. A. Basketter, Jim Bridges, F. Lamplmair, Boris P. Müller, Silvia Casati, A. Irizar, Petra S. Kern, Laura H. Rossi, Sonja Beken, S. Cuvellier, Irene Manou, Miriam N. Jacobs, Bruno Hubesch
Publikováno v:
Regulatory Toxicology and Pharmacology. 117:104767
Skin sensitising substances that induce contact allergy and consequently risk elicitation of allergic contact dermatitis (ACD) remain an important focus regarding the replacement of animal experimentation. Current in vivo methods, notably the local l
Autor:
Dirk Petersohn, Bruno Hubesch, David A. Basketter, Joop de Knecht, Irene Manou, Joanna Jaworska, Emiel Rorije, W. Steiling, Robert Landsiedel, Laura H. Rossi, Andrew Worth, Annette Mehling, Silvia Teissier, Takao Ashikaga, Silvia Casati
Publikováno v:
Regulatory Toxicology and Pharmacology. 73:660-666
In the two years since the last workshop report, the environment surrounding the prediction of skin sensitisation hazards has experienced major change. Validated non-animal tests are now OECD Test Guidelines. Accordingly, the recent cross sector work
Autor:
Els Adriaens, Annette Mehling, E. van Vliet, Boris P. Müller, David A. Basketter, Bruno Hubesch, S. Letasiova, Erwin Ludo Roggen, A. Irizar, Silvia Casati, Martina Klaric, Irene Manou
Publikováno v:
Regulatory Toxicology and Pharmacology. 108:104473
In the last 20 years, alternative approaches to the identification of skin sensitisation hazards have been at the forefront of the 3Rs and have helped refine the validation and acceptance processes. However, experience with the local lymph node assay
Publikováno v:
Regulatory Toxicology and Pharmacology. 72:117-133
Read-across is an alternative approach exploited to address information requirements for risk assessment and for regulatory programmes such as the European Union's REACH regulation. Whilst read-across approaches are accepted in principle, difficultie
Autor:
Bruno Hubesch, Achim Aigner, Reza J. Rasoulpour, Kerstin Schmidt, Alan Poole, Helmut Greim, Tokuo Sukata, Gunter Meister, Jay S. Petrick, Jan Verhaert, Nigel J. Gooderham, Madeleine Laffont, Hervé Seitz, Roland Buesen, Frank J. Slack, Emma L. Marczylo, Timothy W. Gant, Ursula G. Sauer, Jörg Hackermüller, Kenneth W. Witwer, Saskia M. van der Vies
Publikováno v:
Regulatory Toxicology and Pharmacology, 82, 127-139. Academic Press Inc.
Regulatory Toxicology and Pharmacology
Regulatory Toxicology and Pharmacology, Elsevier, 2016, 82, pp.127-139. ⟨10.1016/j.yrtph.2016.09.018⟩
Aigner, A, Buesen, R, Gant, T, Gooderham, N, Greim, H, Hackermuller, J, Hubesch, B, Laffont, M, Marczylo, E, Meister, G, Petrick, J S, Rasoulpour, R J, Sauer, U G, Schmidt, K, Seitz, H, Slack, F, Sukata, T, van der Vies, S M, Verhaert, J, Witwer, K W & Poole, A 2016, ' Advancing the use of noncoding RNA in regulatory toxicology: Report of an ECETOC workshop ', Regulatory Toxicology and Pharmacology, vol. 82, pp. 127-139 . https://doi.org/10.1016/j.yrtph.2016.09.018
Regulatory Toxicology and Pharmacology
Regulatory Toxicology and Pharmacology, Elsevier, 2016, 82, pp.127-139. ⟨10.1016/j.yrtph.2016.09.018⟩
Aigner, A, Buesen, R, Gant, T, Gooderham, N, Greim, H, Hackermuller, J, Hubesch, B, Laffont, M, Marczylo, E, Meister, G, Petrick, J S, Rasoulpour, R J, Sauer, U G, Schmidt, K, Seitz, H, Slack, F, Sukata, T, van der Vies, S M, Verhaert, J, Witwer, K W & Poole, A 2016, ' Advancing the use of noncoding RNA in regulatory toxicology: Report of an ECETOC workshop ', Regulatory Toxicology and Pharmacology, vol. 82, pp. 127-139 . https://doi.org/10.1016/j.yrtph.2016.09.018
The European Centre for the Ecotoxicology and Toxicology of Chemicals (ECETOC) organised a workshop to discuss the state-of-the-art research on noncoding RNAs (ncRNAs) as biomarkers in regulatory toxicology and as analytical and therapeutic agents. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::847085db1b29f812860b87e80a671b46
https://research.vumc.nl/en/publications/e465638d-d163-426f-8021-4378630094ed
https://research.vumc.nl/en/publications/e465638d-d163-426f-8021-4378630094ed