Výsledky vyhledávání - "Bruno Gouritin"

Akademický článek

Interleukin-1 regulates follicular T cells during the germinal center reaction

Autor: Aude Belbezier, Paul Engeroff, Gwladys Fourcade, Hélène Vantomme, Romain Vaineau, Bruno Gouritin, Bertrand Bellier, Isabelle Brocheriou, Nicolas Tchitchek, Stephanie Graff-Dubois, David Klatzmann

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionAntibody production and the generation of memory B cells are regulated by T follicular helper (Tfh) and T follicular regulatory (Tfr) cells in germinal centers. However, the precise role of Tfr cells in controlling antibody production is

Externí odkaz: https://doaj.org/article/1970145b093f439fac4b1076c56464d0

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Akademický článek

Naive and memory CD4+ T cell subsets can contribute to the generation of human Tfh cells

Autor: Raphaël Jeger-Madiot, Romain Vaineau, Maud Heredia, Nicolas Tchitchek, Lisa Bertrand, Mathias Pereira, Océane Konza, Bruno Gouritin, Bénédicte Hoareau-Coudert, Aurélien Corneau, Catherine Blanc, Eric Savier, Pierre Buffet, Adrien Six, David Klatzmann, Arnaud Moris, Stéphanie Graff-Dubois

Publikováno v: iScience, Vol 25, Iss 1, Pp 103566- (2022)

Summary: CD4+ T follicular helper cells (Tfh) promote B cell maturation and antibody production in secondary lymphoid organs. By using an innovative culture system based on splenocyte stimulation, we studied the dynamics of naive and memory CD4+ T ce

Externí odkaz: https://doaj.org/article/30c26f55bada4c14834f204a7eaf205a

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Interleukin-1 regulates follicular T cells during the germinal center reaction

Autor: Aude Belbezier, Paul Engeroff, Gwladys Fourcade, Helene Vantomme, Romain Vaineau, Bruno Gouritin, Bertrand Bellier, Isabelle Brocheriou, Nicolas Tchitchek, Stephanie Graff-Dubois, David Klatzmann

Antibody production by plasma cells and generation of long-term memory B-cells are positively regulated by Tfh cells and negatively regulated by Tfr cells in germinal centers. However, the precise role of Tfr cells in controlling antibody production

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6342ac163c6bae16d86c95fd20030ea2
https://doi.org/10.1101/2023.03.29.534687

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Naive and memory CD4

Autor: Raphaël, Jeger-Madiot, Romain, Vaineau, Maud, Heredia, Nicolas, Tchitchek, Lisa, Bertrand, Mathias, Pereira, Océane, Konza, Bruno, Gouritin, Bénédicte, Hoareau-Coudert, Aurélien, Corneau, Catherine, Blanc, Eric, Savier, Pierre, Buffet, Adrien, Six, David, Klatzmann, Arnaud, Moris, Stéphanie, Graff-Dubois

Publikováno v: iScience

Summary CD4+ T follicular helper cells (Tfh) promote B cell maturation and antibody production in secondary lymphoid organs. By using an innovative culture system based on splenocyte stimulation, we studied the dynamics of naive and memory CD4+ T cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e47f06e080d2c400040c9b8667c37a02
https://pubmed.ncbi.nlm.nih.gov/34984326

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Impaired Activated/Memory Regulatory T Cell Clonal Expansion Instigates Diabetes in NOD Mice

Autor: Pierre Barennes, Paul-Gydeon Ritvo, Hang P. Pham, Vanessa Mhanna, Valentin Quiniou, Encarnita Mariotti-Ferrandiz, Guillaume Churlaud, Bruno Gouritin, Faustine Brimaud, Gwladys Fourcade, Adrien Six, David Klatzmann

Publikováno v: Diabetes
Diabetes, American Diabetes Association, 2021, 70 (4), pp.976-985. ⟨10.2337/db20-0896⟩
Diabetes, 2021, 70 (4), pp.976-985. ⟨10.2337/db20-0896⟩

Regulatory T cell (Treg) insufficiency licenses the destruction of insulin-producing pancreatic b cells by auto-reactive effector T cells (Teffs), causing spontaneous autoimmune diabetes in non‑obese diabetic (NOD) mice. We investigated the contrib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e472da27d13bb23e6d49fceb1a208ea
https://hal.sorbonne-universite.fr/hal-03263428

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Impaired Activated/Memory Regulatory T Cell Clonal Expansion Instigates Diabetes in NOD Mice

Autor: David Klatzmann, Encarnita Mariotti-Ferrandiz, Adrien Six, Guillaume Churlaud, Bruno Gouritin, Faustine Brimaud, Paul-Gydeon Ritvo, Hang P. Pham, Valentin Quiniou, Pierre Barennes, Gwladys Fourcade, Vanessa Mhanna, Ada Admin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::797ab97a27f067a30ab59c3403c7d7fa
https://doi.org/10.2337/figshare.13611020.v1

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Quantification and localization of PEGylated polycyanoacrylate nanoparticles in brain and spinal cord during experimental allergic encephalomyelitis in the rat

Autor: Pilar Calvo, Christophe Klein, Patrick Couvreur, Françoise Eclancher, Claudia Giannavola, Bruno Gouritin, Henri Villarroya, Jean P. Andreux

Publikováno v: European Journal of Neuroscience. 15:1317-1326

Under healthy conditions, the blood-brain barrier (BBB) limits the passage of solutes and cells from the blood to the CNS. During neurological diseases, BBB permeability increases dramatically and it has been hypothesized that drug carrier systems su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b328b802ccb4f0e62215d107fc9c702d
https://doi.org/10.1046/j.1460-9568.2002.01967.x

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Insulin‐loaded nanocapsules for oral administration: In vitro and in vivo investigation

Autor: Malam Aboubakar, Huguette Pinto-Alphandary, Francis Puisieux, Christine Vauthier, Bruno Gouritin, Robert Farinotti, Bernard Lacour, Patrick Couvreur

Publikováno v: Drug Development Research. 49:109-117

The purpose of this work was to investigate the ability of poly(isobutylcyanoacrylate) nanocapsules to protect insulin from degradation by proteolytic enzymes providing biologically active insulin by the oral route. Insulin was labeled with Texas Red

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d2c4105df6ffd5922284c9bcd20ebe5f
https://doi.org/10.1002/(sici)1098-2299(200002)49:2<109::aid-ddr4>3.0.co

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[Untitled]

Autor: Colette Weingarten, Jean-Paul Andreux, Patrick Couvreur, Valérie Guilloux, Marina Demoy, Bruno Gouritin

Publikováno v: Pharmaceutical Research. 16:37-41

Purpose. To investigate the influence of animal species and nanoparticle surface characteristics on the intrasplenic distribution of polystyrene nanoparticles.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::805df847bf2f0ac2970c72f6568d7324
https://doi.org/10.1023/a:1018858409737

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[Untitled]

Autor: Jean P. Andreux, Bruno Gouritin, Stéphane Gibaud, Patrick Couvreur, Marina Demoy, Colette Weingarten

Publikováno v: Pharmaceutical Research. 14:463-468

Purpose. To identify more accurately in the spleen, the areas and the cells where nanoparticulate carriers were taken up from the blood flow, a series of complementary approaches were used.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f5be22aa8a5f2e094268de7c38fb748
https://doi.org/10.1023/a:1012095431931

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