Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Bruno G. Oertel"'
Publikováno v:
IBRO Reports, Vol 7, Iss , Pp 117-128 (2019)
Background: Cannabis proofed to be effective in pain relief, but one major side effect is its influence on memory in humans. Therefore, the role of memory on central processing of nociceptive information was investigated in healthy volunteers. Method
Externí odkaz:
https://doaj.org/article/1135d487fb454d9da14d6806039852f8
Autor:
Jörn Lötsch, Dario Kringel, Gerd Geisslinger, Bruno G. Oertel, Eduard Resch, Sebastian Malkusch
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 12, p 4367 (2020)
Genetic association studies have shown their usefulness in assessing the role of ion channels in human thermal pain perception. We used machine learning to construct a complex phenotype from pain thresholds to thermal stimuli and associate it with th
Externí odkaz:
https://doaj.org/article/f52539c8076449028c62699e09431392
Autor:
Miriam Wolters, Martin Zunftmeister, T. Rossmanith, Gerd Geisslinger, Carmen Walter, Bruno G. Oertel, Jörn Lötsch, Nerea Ferreirós, Sebastian Zinn
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 126:318-331
Persistent and, in particular, neuropathic pain is a major healthcare problem with still insufficient pharmacological treatment options. This triggered research activities aimed at finding analgesics with a novel mechanism of action. Results of these
Autor:
Dario Kringel, Bruno G. Oertel, Eduard Resch, Sebastian Malkusch, Jörn Lötsch, Gerd Geisslinger
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 4367, p 4367 (2020)
Volume 21
Issue 12
International Journal of Molecular Sciences, Vol 21, Iss 4367, p 4367 (2020)
Volume 21
Issue 12
Genetic association studies have shown their usefulness in assessing the role of ion channels in human thermal pain perception. We used machine learning to construct a complex phenotype from pain thresholds to thermal stimuli and associate it with th
Publikováno v:
European Journal of Clinical Pharmacology
Purpose The antifungal drugs ketoconazole and itraconazole reduce serum concentrations of 4β-hydroxycholesterol, which is a validated marker for hepatic cytochrome P450 (CYP) 3A4 activity. We tested the effect of another antifungal triazole agent, f
Autor:
Sarah Heinemann, Dario Kringel, Jörn Lötsch, Eduard Resch, Bruno G. Oertel, Gerd Geisslinger, Michael C. Thrun
Publikováno v:
Pain
Supplemental Digital Content is Available in the Text. Machine-learning methods associated next generation–based genotypes with the response to hypersensitization to heat induced by topical application of capsaicin.
Heat pain and its modulatio
Heat pain and its modulatio
Autor:
Jörn Lötsch, Johannes Vermehren, Ralf Deichmann, Carmen Walter, Bruno G. Oertel, Lisa Felden, Ulrike Nöth
Publikováno v:
European Journal of Clinical Pharmacology. 73:1579-1587
Considering the increasing acknowledgment of the human sense of smell as a significant component of the quality of life, olfactory drug effects gain potential clinical importance. A recent observation in a human experimental context indicated that Δ
Autor:
Bruno G. Oertel, Jörn Lötsch, Alfred Ultsch, Gerd Geisslinger, Sarah Heinemann, Florian Lerch
Publikováno v:
Pain
Machine learning identified differences in ultraviolet-B– and capsaicin-induced hypersensitization in the quantitative sensory testing parameter patterns acquired in 82 healthy subjects.
The comprehensive assessment of pain-related human pheno
The comprehensive assessment of pain-related human pheno
Autor:
Alfred Ultsch, Claudia Knothe, Mattias Kettner, Peter H. Schmidt, Bruno G. Oertel, Cora Wunder, Stefan W. Toennes, Jörn Lötsch, Gerd Geisslinger
Publikováno v:
Epigenomics. 8:1583-1599
Aim: Exposure to opioids has been associated with epigenetic effects. Studies in rodents suggested a role of varying degrees of DNA methylation in the differential regulation of μ-opioid receptor expression across the brain. Methods: In a translatio
Autor:
Gerd Geisslinger, Andreas Binder, Christoph Maier, Florian Henrich, Thomas Klein, Janne Gierthmühlen, Rolf-Detlef Treede, Ralf Baron, Jörn Lötsch, Bruno G. Oertel, Walter Magerl, Thomas R. Tölle, Philipp Hüllemann, Jan Vollert, Elena K. Enax-Krumova, Sigrid Schuh-Hofer
As an indirect approach to relate previously identified sensory phenotypes of patients suffering from peripheral neuropathic pain to underlying mechanisms, we used a published sorting algorithm to estimate the prevalence of denervation, peripheral an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cae45fa5a34064f9d02af22dcea4ac5
https://publica.fraunhofer.de/handle/publica/260556
https://publica.fraunhofer.de/handle/publica/260556