Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Bruno G. Frenguelli"'
Autor:
Mark J. Wall, Emily Hill, Robert Huckstepp, Kerry Barkan, Giuseppe Deganutti, Michele Leuenberger, Barbara Preti, Ian Winfield, Sabrina Carvalho, Anna Suchankova, Haifeng Wei, Dewi Safitri, Xianglin Huang, Wendy Imlach, Circe La Mache, Eve Dean, Cherise Hume, Stephanie Hayward, Jess Oliver, Fei-Yue Zhao, David Spanswick, Christopher A. Reynolds, Martin Lochner, Graham Ladds, Bruno G. Frenguelli
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Wall et al. describe the selective activation of an adenosine A1 receptor-mediated intracellular pathway that provides potent analgesia in the absence of sedation or cardiorespiratory depression, paving the way for novel medicines based on the far-re
Externí odkaz:
https://doaj.org/article/248fd0638f5942beb0219612bf9fe670
Autor:
Baoping Chen, David Perry, James Teahan, Ian J. McPherson, James Edmondson, Minkyung Kang, Dimitrios Valavanis, Bruno G. Frenguelli, Patrick R. Unwin
Publikováno v:
ACS Measurement Science Au, Vol 1, Iss 1, Pp 6-10 (2021)
Externí odkaz:
https://doaj.org/article/a9ce9c6024b747b78b84beec0dd37aee
Autor:
Patrick Amoateng, Thomas A. Tagoe, Thomas K. Karikari, Kennedy K. E Kukuia, Dorcas Osei-Safo, Eric Woode, Bruno G. Frenguelli, Samuel B. Kombian
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Extracts of the tropical Cinderella plant Synedrella nodiflora are used traditionally to manage convulsive conditions in the West African sub-region. This study sought to determine the neuronal basis of the effectiveness of these plant extracts to su
Externí odkaz:
https://doaj.org/article/83e0485deae346c9a75dda3606a908ec
Publikováno v:
Biology Open, Vol 6, Iss 10, Pp 1434-1444 (2017)
Neurodegenerative tauopathies are characterised by accumulation of hyperphosphorylated tau aggregates primarily degraded by autophagy. The 5′AMP-activated protein kinase (AMPK) is expressed in most cells, including neurons. Alongside its metabolic
Externí odkaz:
https://doaj.org/article/9d610f3feed54b8c9856733997a1183d
Autor:
Gary L. Stiles, Ulrich Schwabe, Christa E. Müller, Joel Linden, Karl-Norbert Klotz, Kenneth A. Jacobson, Adriaan P. IJzerman, Rebecca Hills, Bruno G. Frenguelli, Bertil B. Fredholm
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
Adenosine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Adenosine Receptors [112]) are activated by the endogenous ligand adenosine (potentially inosine also at A3 receptors). Crystal structures for the antagonist-bound [155, 316
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dc4b5988ea942e62d534968888f2e3d
https://doi.org/10.2218/gtopdb/f3/2023.1
https://doi.org/10.2218/gtopdb/f3/2023.1
Autor:
Emily Hill, Xianglin Huang, Ivana Del Popolo, Circe La Mache, Martin Lochner, Graham Ladds, Bruno G. Frenguelli, Mark J. Wall
SummaryWe have previously reported that in rat hippocampal area CA1, the A1R-selective agonist, BnOCPA, potently inhibited excitatory synaptic transmission but did not cause membrane hyperpolarisation in CA1 pyramidal neurons, as would be expected of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3a0608d52e5c70e4b6300aaabc32aab
https://doi.org/10.1101/2022.12.02.518704
https://doi.org/10.1101/2022.12.02.518704
Publikováno v:
Neuropharmacology. 224
Purine-based molecules play ancient, fundamental, and evolutionarily-conserved roles across life on Earth, ranging from DNA and RNA, to the universal energy currency, ATP. In mammals, the two primary routes for the synthesis of the adenine nucleotide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a92b74a5f8ef492c502eefb235e3ba9a
https://pubmed.ncbi.nlm.nih.gov/36493858
https://pubmed.ncbi.nlm.nih.gov/36493858
Autor:
Lorenzo Morè, Lucia Privitera, Philippa Perrett, Daniel D. Cooper, Manuel Van Gijsel Bonnello, J. Simon C. Arthur, Bruno G. Frenguelli
The transcription factor cAMP response element binding protein (CREB) is widely regarded as orchestrating the genomic response that underpins a range of physiological functions in the central nervous system, including learning and memory. Of the mean
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de8f766d9f84b8dd9bed3e7b6a7bbd63
http://wrap.warwick.ac.uk/168875/1/WRAP-CREB-serine-spatial-cognitive-flexibility-long-term-potentiation-22.pdf
http://wrap.warwick.ac.uk/168875/1/WRAP-CREB-serine-spatial-cognitive-flexibility-long-term-potentiation-22.pdf
Autor:
Bruno G. Frenguelli, Nicholas Dale
Publikováno v:
Neurosci Bull
The purines constitute a family of inter-related compounds that serve a broad range of important intracellular and extracellular biological functions. In particular, adenosine triphosphate (ATP) and its metabolite and precursor, adenosine, regulate a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87acaf2a8f46892479cc789bd3eaf963
https://doi.org/10.1007/s12264-020-00529-z
https://doi.org/10.1007/s12264-020-00529-z
Autor:
J. Simon C. Arthur, Daniel D. Cooper, Bruno G. Frenguelli, Daniel Hebenstreit, Marianthi Tsogka, Lorenzo Morè, Philippa Richardson, Lucia Privitera
Publikováno v:
The Journal of Neuroscience
Experience powerfully influences neuronal function and cognitive performance, but the cellular and molecular events underlying the experience-dependent enhancement of mental ability have remained elusive. In particular, the mechanisms that couple the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b84fb988e88ca58dda9082c5c31585
http://europepmc.org/articles/PMC7294801
http://europepmc.org/articles/PMC7294801