Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Bruno Filoche"'
Autor:
Monsif Bouaboula, Laurent Debussche, Carlos Garcia-Echeverria, Hong Cheng, Bruno Filoche-Rommé, Gary McCort, Fabienne Thompson, Victor Certal, Michel Tabart, Frank Halley, Youssef El-Ahmad, Laurent Schio, Pierre-Yves Abecassis, Dinesh S. Bangari, Anne Caron, Laurent Besret, Joon Sang Lee, Jack Pollard, Hui Cao, Rosalia Arrebola, Albane Courjaud, Dietmar Hoffmann, Mikhail N. Levit, Jessica McManus, Andrew T. Hebert, Zhuyan Guo, Malvika Koundinya, Fangxian Sun, Jane Cheng, Maysoun Shomali
Primary treatment for estrogen receptor-positive (ER+) breast cancer is endocrine therapy. However, substantial evidence indicates a continued role for ER signaling in tumor progression. Selective estrogen receptor degraders (SERD), such as fulvestra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b86af78b2f4b0ea0bc017ba86b84056
https://doi.org/10.1158/1535-7163.c.6542763
https://doi.org/10.1158/1535-7163.c.6542763
Autor:
Monsif Bouaboula, Laurent Debussche, Carlos Garcia-Echeverria, Hong Cheng, Bruno Filoche-Rommé, Gary McCort, Fabienne Thompson, Victor Certal, Michel Tabart, Frank Halley, Youssef El-Ahmad, Laurent Schio, Pierre-Yves Abecassis, Dinesh S. Bangari, Anne Caron, Laurent Besret, Joon Sang Lee, Jack Pollard, Hui Cao, Rosalia Arrebola, Albane Courjaud, Dietmar Hoffmann, Mikhail N. Levit, Jessica McManus, Andrew T. Hebert, Zhuyan Guo, Malvika Koundinya, Fangxian Sun, Jane Cheng, Maysoun Shomali
1022 gene signature from RNAseq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c10eddd92e318753beaf14063960214f
https://doi.org/10.1158/1535-7163.22520766
https://doi.org/10.1158/1535-7163.22520766
Autor:
Monsif Bouaboula, Laurent Debussche, Carlos Garcia-Echeverria, Hong Cheng, Bruno Filoche-Rommé, Gary McCort, Fabienne Thompson, Victor Certal, Michel Tabart, Frank Halley, Youssef El-Ahmad, Laurent Schio, Pierre-Yves Abecassis, Dinesh S. Bangari, Anne Caron, Laurent Besret, Joon Sang Lee, Jack Pollard, Hui Cao, Rosalia Arrebola, Albane Courjaud, Dietmar Hoffmann, Mikhail N. Levit, Jessica McManus, Andrew T. Hebert, Zhuyan Guo, Malvika Koundinya, Fangxian Sun, Jane Cheng, Maysoun Shomali
supplemental methods, data and figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3813137435b6e50ede54df16b76c6dfc
https://doi.org/10.1158/1535-7163.22520769.v1
https://doi.org/10.1158/1535-7163.22520769.v1
Autor:
Ben Gold, Jun Zhang, Landys Lopez Quezada, Julia Roberts, Yan Ling, Madeleine Wood, Wasima Shinwari, Laurent Goullieux, Christine Roubert, Laurent Fraisse, Eric Bacqué, Sophie Lagrange, Bruno Filoche-Rommé, Michal Vieth, Philip A. Hipskind, Louis N. Jungheim, Jeffrey Aubé, Sarah M. Scarry, Stacey L. McDonald, Kelin Li, Andrew Perkowski, Quyen Nguyen, Véronique Dartois, Matthew Zimmerman, David B. Olsen, Katherine Young, Shilah Bonnett, Douglas Joerss, Tanya Parish, Helena I. Boshoff, Kriti Arora, Clifton E. Barry, Laura Guijarro, Sara Anca, Joaquín Rullas, Beatriz Rodríguez-Salguero, Maria S. Martínez-Martínez, Esther Porras-De Francisco, Monica Cacho, David Barros-Aguirre, Paul Smith, Steven J. Berthel, Carl Nathan, Robert H. Bates
Publikováno v:
ACS Infectious Diseases. 8:557-573
Rising antimicrobial resistance challenges our ability to combat bacterial infections. The problem is acute for tuberculosis (TB), the leading cause of death from infection before COVID-19. Here, we developed a framework for multiple pharmaceutical c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10fbb240736098b21d77522307cf2134
https://doi.org/10.1021/acsinfecdis.1c00570
https://doi.org/10.1021/acsinfecdis.1c00570
Autor:
Ben, Gold, Jun, Zhang, Landys Lopez, Quezada, Julia, Roberts, Yan, Ling, Madeleine, Wood, Wasima, Shinwari, Laurent, Goullieux, Christine, Roubert, Laurent, Fraisse, Eric, Bacqué, Sophie, Lagrange, Bruno, Filoche-Rommé, Michal, Vieth, Philip A, Hipskind, Louis N, Jungheim, Jeffrey, Aubé, Sarah M, Scarry, Stacey L, McDonald, Kelin, Li, Andrew, Perkowski, Quyen, Nguyen, Véronique, Dartois, Matthew, Zimmerman, David B, Olsen, Katherine, Young, Shilah, Bonnett, Douglas, Joerss, Tanya, Parish, Helena I, Boshoff, Kriti, Arora, Clifton E, Barry, Laura, Guijarro, Sara, Anca, Joaquín, Rullas, Beatriz, Rodríguez-Salguero, Maria S, Martínez-Martínez, Esther, Porras-De Francisco, Monica, Cacho, David, Barros-Aguirre, Paul, Smith, Steven J, Berthel, Carl, Nathan, Robert H, Bates
Publikováno v:
ACS infectious diseases. 8(3)
Rising antimicrobial resistance challenges our ability to combat bacterial infections. The problem is acute for tuberculosis (TB), the leading cause of death from infection before COVID-19. Here, we developed a framework for multiple pharmaceutical c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::845c19ee1302d9cba5efc30dfaea239a
https://pubmed.ncbi.nlm.nih.gov/35192346
https://pubmed.ncbi.nlm.nih.gov/35192346
Autor:
Chrystelle Girardet, Magali Mathieu, François Vallée, Jacques Le-Roux, Fangxian Sun, Laurence Fabien, Corinne Terrier, Celine Ginesty, Bruno Filoche-Romme, Florence Gruss-Leleu, Maysoun Shomali, Monsif Bouaboula, Sylvie Beccari, Pascal Desmazeau, Gilles Lebourg, Tsiala Benard, Victor Certal, Pascale Vicat, Andrew Hebert, Carlos Garcia-Echeverria, Laurent Schio, Youssef El-Ahmad, Gary Mccort, Claire Muller, Maurice Brollo, Mikhail Levit, Luc Bertin, Hong Cheng, Véronique Loyau, Valerie Steier, Fabienne Thompson, Audrey Louboutin, Fabienne Pilorge, Alexey Rak, Frank Halley, Patrick Richepin, Christelle Perrault, Pierre-Yves Abecassis, Michel Tabart, Albane Courjaud
Publikováno v:
Journal of Medicinal Chemistry. 63:512-528
More than 75% of breast cancers are estrogen receptor alpha (ERα) positive (ER+), and resistance to current hormone therapies occurs in one-third of ER+ patients. Tumor resistance is still ERα-dependent, but mutations usually confer constitutive ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb6b8e31876cd3009f301f509589bd98
https://doi.org/10.1021/acs.jmedchem.9b01293
https://doi.org/10.1021/acs.jmedchem.9b01293
Publikováno v:
Assay and Drug Development Technologies
Inwardly rectifying IK1 potassium currents of the heart control the resting membrane potential of ventricular cardiomyocytes during diastole and contribute to their repolarization after each action potential. Mutations in the gene encoding Kir2.1 cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436f02d8e40d5ddbccdad38bf7627432
http://europepmc.org/articles/PMC6479253
http://europepmc.org/articles/PMC6479253
Autor:
Youssef El-Ahmad, Hong Cheng, Fabienne Thompson, Monsif Bouaboula, Jack Pollard, Gary Mccort, Andrew Hebert, Carlos Garcia-Echeverria, Michel Tabart, Fangxian Sun, Laurent Schio, Joon Sang Lee, Dinesh S. Bangari, Jane Cheng, Laurent Besret, Hui Cao, Dietmar Hoffmann, Maysoun Shomali, Rosalia Arrebola, Zhuyan Guo, Anne Caron, Laurent Debussche, Frank Halley, Bruno Filoche-Romme, Albane Courjaud, Mikhail Levit, Malvika Koundinya, Jessica McManus, Victor Certal, Pierre-Yves Abecassis
Publikováno v:
Molecular cancer therapeutics. 20(2)
Primary treatment for estrogen receptor-positive (ER+) breast cancer is endocrine therapy. However, substantial evidence indicates a continued role for ER signaling in tumor progression. Selective estrogen receptor degraders (SERD), such as fulvestra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a793f8b26300e48375f0775740c17d0
https://pubmed.ncbi.nlm.nih.gov/33310762
https://pubmed.ncbi.nlm.nih.gov/33310762
Autor:
Jean Pierre Marquette, Andreas Karlsson, Sylvie Monget, Thomas Bertrand, Jean Christophe Carry, Frank Halley, Marc Antoine Perrin, Jean Paul Nicolas, Tsiala Benard, Angela Virone-Oddos, Luc Bertin, Céline Amara, Hélène Bonnevaux, Laurence Delbarre, Gilles Doerflinger, Pierre Yves Abecassis, Youssef El-Ahmad, Véronique Charrier, Victor Certal, Bruno Filoche-Romme, Florence Gruss-Leleu, Sébastien Perron, Alexey Rak, Patrick Richepin, Stephane Guerif, Carlos Garcia-Echeverria, Loic Vincent, Nadine Michot, Magali Mathieu, Véronique Loyau, Olivier Lemaitre, Maurice Brollo, Christoph Lengauer, Houlfa Guizani, Laurent Schio, Fabienne Thompson, Cécile Delorme
Publikováno v:
Journal of Medicinal Chemistry. 57:903-920
Compelling molecular biology publications have reported the implication of phosphoinositide kinase PI3Kβ in PTEN-deficient cell line growth and proliferation. These findings supported a scientific rationale for the development of PI3Kβ-specific inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c85553ea8c69d86eeaefddb3c7297b6
https://doi.org/10.1021/jm401642q
https://doi.org/10.1021/jm401642q
Autor:
Cécile Delorme, Angela Virone-Oddos, Bernadette Tric, Audrey Louboutin, Fabienne Thompson, Christoph Lengauer, Loic Vincent, Nadine Michot, Isabelle Vade, Jean Paul Nicolas, Frank Halley, Youssef El-Ahmad, Bruno Filoche-Romme, Hélène Bonnevaux, Andreas Karlsson, Sylvie Monget, Renaud Morales, Victor Certal, Laurent Schio, Gilles Doerflinger, Sébastien Perron, Jean Christophe Carry, Pierre Yves Abecassis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6381-6384
From a HTS campaign, a new series of pyrimidone anilides exemplified by compound 1 has been identified with good inhibitory activity for the PI3Kβ isoform. The structure of compound 1 in PI3Kγ was solved revealing a binding mode in agreement with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a7ad294cd6eed46f1ac36681f76724
https://doi.org/10.1016/j.bmcl.2012.08.072
https://doi.org/10.1016/j.bmcl.2012.08.072