First Hyperpolarizability of 1,3-Thiazolium-5-Thiolates Mesoionic Compounds

Autor: Cid B. de Araújo, Renato Barbosa-Silva, Petrônio Filgueiras de Athayde-Filho, Bruno F. Lira, Maxwell A. M. Nogueira, Helivaldo Diógenes da Silva Souza

Publikováno v: The Journal of Physical Chemistry C. 123:677-683

The first hyperpolarizabilities of the mesoionic compounds (MICs) 2-(4-chlorophenyl)-3-methyl-4-phenyl-1,3-thiazolium-5-thiolate (MIC-1), 2-(4-chlorophenyl)-3-methyl-4-(4-methylphenyl)-1,3-thiazoli...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::556b5b3d15b6953cff5382ef2079356d
https://doi.org/10.1021/acs.jpcc.8b09649

Synthesis, in silico Study, Theoretical Stereochemistry Elucidation and Antifungal Activity of New Imides Derived from Safrole

Autor: Gerd B. Rocha, Laísa Vilar Cordeiro, José Maria Barbosa-Filho, Raquel F. Vilela, Petrônio Filgueiras de Athayde-Filho, Bruno F. Lira, Helivaldo Diógenes da Silva Souza, Normando Alexandre da Silva Costa, Edeltrudes de Oliveira Lima, Luiz Eduardo Gomes da Cruz, Kelyonara M. S. de Assis

Publikováno v: Journal of the Brazilian Chemical Society, Volume: 31, Issue: 10, Pages: 2091-2103, Published: 09 OCT 2020
Journal of the Brazilian Chemical Society v.31 n.10 2020
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ

Ten imides derived from safrole, 4a-4j, were synthesized and their structures were fully characterized by infrared (IR) spectroscopy, 1H and 13C nuclear magnetic resonance (NMR) spectroscopy and high resolution mass spectrometry (HRMS) analysis. Amon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59604513c96ca9c0a83d9e75251ce03e
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532020001002091&lng=en&tlng=en

New Diesters Derived from Piperine: in silico Study and Evaluation of Their Antimicrobial Potential

Autor: Edeltrudes de Oliveira Lima, José Maria Barbosa-Filho, Emmely Oliveira Da Trindade, Bruno F. Lira, Petrônio Filgueiras de Athayde-Filho, Helivaldo Diógenes da Silva Souza, Maria Cláudia Rodrigues Brandão, Hermes Diniz Neto

Publikováno v: Journal of the Brazilian Chemical Society v.31 n.8 2020
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ
Journal of the Brazilian Chemical Society, Volume: 31, Issue: 8, Pages: 1668-1678, Published: 27 JUL 2020

Piperine, previously extracted from black pepper (Piper nigrum L.), was used as a precursor for the synthesis of twelve new diester derivatives. The final products were obtained through the bimolecular nucleophilic substitution reaction (SN2) of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5edb8a0b287978f2c07b21974a027522
https://doi.org/10.21577/0103-5053.20200053

Th1-Biased Immunomodulation and In Vivo Antitumor Effect of a Novel Piperine Analogue

Autor: José Maria Barbosa-Filho, Monalisa Taveira Brito, Tatyanna Kelvia Gomes de Sousa, Helivaldo Diógenes da Silva Souza, Jephesson Alex Floriano dos Santos, Rafael Carlos Ferreira, Hemerson Iury Ferreira Magalhães, Tatianne Mota Batista, Normando Alexandre da Silva Costa, Marianna Vieira Sobral, Fagner Carvalho Leite, Vivianne Mendes Mangueira, Ryldene Marques Duarte da Cruz, Bruno F. Lira, Giciane Carvalho Vieira, Petrônio Filgueiras de Athayde-Filho, Robson Cavalcante Veras, Ana Paula Gomes Moura

Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 9, p 2594 (2018)
International Journal of Molecular Sciences
Volume 19
Issue 9

Natural products have an important role as prototypes in the synthesis of new anticancer drugs. Piperine is an alkaloid amide with antitumor activity and significant toxicity. Then, the N-(p-nitrophenyl)acetamide piperinoate (HE-02) was synthesized,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47a4a3f1c125d39ea5ed69b978875f9
http://www.mdpi.com/1422-0067/19/9/2594

Synthesis and Antifungal Activity AgainstCandidaStrains of Mesoionic System Derived From 1,3-Thyazolium-5-thiolate

Autor: Helivaldo Diógenes da Silva Souza, José Maria Barbosa-Filho, Isabelle N. Peixoto, Bruno F. Lira, Edeltrudes de Oliveira Lima, Daniele de Figueredo Silva, Petrônio Filgueiras de Athayde-Filho

Publikováno v: Journal of the Brazilian Chemical Society.

A series of ten new compounds have been synthetized in satisfactory yields (85-95%) through the treatment of isopropyl mesoionic 1,3-thiazolium-5-thiolate with 2-chloro-N-arylacetamides and characterized by elemental analysis, infrared (IR), 1H and 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b66e2299cd9452b2f786849637f42ea3
https://doi.org/10.5935/0103-5053.20160063