Zobrazeno 1 - 10
of 867
pro vyhledávání: '"Bruno Dubois"'
Autor:
Filipa Raposo Pereira, Nathalie George, Gianfranco Dalla Barba, Bruno Dubois, Valentina La Corte
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
IntroductionAnticipating the diagnosis of Alzheimer’s disease (AD) at an early asymptomatic at-risk stage, where therapeutics can more effectively delay conscious cognitive decline, is currently among the biggest challenges in the field. Herein, we
Externí odkaz:
https://doaj.org/article/5cc9099ff2f64e098010435366f2e330
Autor:
Ilse Bader, Ilona Bader, Isadora Lopes Alves, David Vállez García, Bruno Vellas, Bruno Dubois, Mercè Boada, Marta Marquié, Daniele Altomare, Philip Scheltens, Rik Vandenberghe, Bernard Hanseeuw, Michael Schöll, Giovanni B. Frisoni, Frank Jessen, Agneta Nordberg, Miia Kivipelto, Craig W. Ritchie, Oriol Grau-Rivera, José Luis Molinuevo, Lisa Ford, Andrew Stephens, Rossella Gismondi, Juan Domingo Gispert, Gill Farrar, Frederik Barkhof, Pieter Jelle Visser, Lyduine E. Collij, on behalf of the AMYPAD consortium
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Background The mismatch between the limited availability versus the high demand of participants who are in the pre-dementia phase of Alzheimer’s disease (AD) is a bottleneck for clinical studies in AD. Nevertheless, potential enrollment ba
Externí odkaz:
https://doaj.org/article/53ca117657b04d869c1e2fc37d173899
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-13 (2023)
Abstract Background Development of in vivo biomarkers has shifted the diagnosis of Alzheimer’s disease (AD) from the later dementia stages of disease towards the earlier stages and has introduced the potential for pre-symptomatic diagnosis. The Int
Externí odkaz:
https://doaj.org/article/6ef378f488594f9284b13f978bebc207
Autor:
Patricia Diaz-Galvan, Giulia Lorenzon, Rosaleena Mohanty, Gustav Mårtensson, Enrica Cavedo, Simone Lista, Andrea Vergallo, Kejal Kantarci, Harald Hampel, Bruno Dubois, Michel J. Grothe, Daniel Ferreira, Eric Westman
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Background Donepezil is an approved therapy for the treatment of Alzheimer’s disease (AD). Results across clinical trials have been inconsistent, which may be explained by design-methodological issues, the pathophysiological heterogeneity
Externí odkaz:
https://doaj.org/article/c3cc3689759d4049ac3b5074cde45ab8
Autor:
Katia Andrade, Thomas Guieysse, Takfarinas Medani, Etienne Koechlin, Dimitrios Pantazis, Bruno Dubois
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
Although neurocognitive models have been proposed to explain anosognosia in Alzheimer’s disease (AD), the neural cascade responsible for its origin in the human brain remains unknown. Here, we build on a mechanistic dual-path hypothesis that brings
Externí odkaz:
https://doaj.org/article/f8566ebb0e954075a1b279cfd4d02b85
Autor:
Patricia Diaz‑Galvan, Giulia Lorenzon, Rosaleena Mohanty, Gustav Mårtensson, Enrica Cavedo, Simone Lista, Andrea Vergallo, Kejal Kantarci, Harald Hampel, Bruno Dubois, Michel J. Grothe, Daniel Ferreira, Eric Westman
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-3 (2023)
Externí odkaz:
https://doaj.org/article/af51c3e57c2549dfbabd6343c0258b3c
Autor:
Constance Lesoil, Stéphanie Bombois, Octave Guinebretiere, Marion Houot, Mahsa Bahrami, Marcel Levy, Rémy Genthon, Frédérique Bozon, Heidy Jean-Marie, Stéphane Epelbaum, Pierre Foulon, Nicolas Villain, Bruno Dubois
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-13 (2023)
Abstract Background There is a need for a reliable, easy-to-use, widely available, and validated tool for timely cognitive impairment identification. We created a computerized cognitive screening tool (Santé-Cerveau digital tool (SCD-T)) including v
Externí odkaz:
https://doaj.org/article/8996b1a91c284e2986eb5611413b650e
Autor:
Bruno Dubois, Jesús López-Arrieta, Stanley Lipschitz, Triantafyllos Doskas, Luiza Spiru, Svitlana Moroz, Olena Venger, Patrick Vermersch, Alain Moussy, Colin D. Mansfield, Olivier Hermine, Magda Tsolaki, for the AB09004 Study Group Investigators
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-10 (2023)
Abstract Background Masitinib is an orally administered tyrosine kinase inhibitor that targets activated cells of the neuroimmune system (mast cells and microglia). Study AB09004 evaluated masitinib as an adjunct to cholinesterase inhibitor and/or me
Externí odkaz:
https://doaj.org/article/83c798131c8243d0a378ebbc75a7c528
Autor:
Katia Andrade, Nesma Houmani, Thomas Guieysse, Solofo Razafimahatratra, André Klarsfeld, Gérard Dreyfus, Bruno Dubois, François Vialatte, Takfarinas Medani
Publikováno v:
Journal of Integrative Neuroscience, Vol 23, Iss 3, p 67 (2024)
Background: Electroencephalography (EEG) stands as a pivotal non-invasive tool, capturing brain signals with millisecond precision and enabling real-time monitoring of individuals’ mental states. Using appropriate biomarkers extracted from these EE
Externí odkaz:
https://doaj.org/article/14bc0110a5e34bd3bcb6f27f61a130b4
Autor:
Walid Khrouf, Dario Saracino, Benoit Rucheton, Marion Houot, Fabienne Clot, Daisy Rinaldi, Joana Vitor, Marie Huynh, Evelyne Heng, Dimitri Schlemmer, Florence Pasquier, Vincent Deramecourt, Sophie Auriacombe, Carole Azuar, Richard Levy, Stéphanie Bombois, Claire Boutoleau-Brétonnière, Jérémie Pariente, Mira Didic, David Wallon, Frédérique Fluchère, Stéphane Auvin, Imen Ben Younes, Yann Nadjar, Alexis Brice, Bruno Dubois, Dominique Bonnefont-Rousselot, Isabelle Le Ber, Foudil Lamari
Publikováno v:
Neurobiology of Disease, Vol 181, Iss , Pp 106108- (2023)
GRN mutations are among the main genetic causes of frontotemporal dementia (FTD). Considering the progranulin involvement in lysosomal homeostasis, we aimed to evaluate if plasma lysosphingolipids (lysoSPL) are increased in GRN mutation carriers, and
Externí odkaz:
https://doaj.org/article/74d41b87d2e9459a8fa3e729c04253b6