Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Bruno Doiron"'
Autor:
Bruno Doiron, Ralph A. DeFronzo
Publikováno v:
Carcinogenesis
Pancreatic cancer has remained refractory to treatment. In large part, this results from the lack of an animal model that mimics pancreatic cancer in man. We describe a novel experimental model of pancreatic cancer that shares the genetic background,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::617dc35e38e7fa26e63a58e0da69ebb1
http://europepmc.org/articles/PMC5862347
http://europepmc.org/articles/PMC5862347
Publikováno v:
Current Pharmaceutical Biotechnology
Insulin replacement therapy is essential in type 1 diabetic individuals and is required in ~40- 50% of type 2 diabetics during their lifetime. Prior attempts at beta cell regeneration have relied upon pancreatic injury to induce beta cell proliferati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d5cc5a08aeee1d6c9c68a22b543ba5
https://pubmed.ncbi.nlm.nih.gov/26696016
https://pubmed.ncbi.nlm.nih.gov/26696016
Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression
Autor:
Bruno Doiron, Axel Kahn, Guy A. Rutter, Ian P. Salt, Gabriela da Silva Xavier, D. Grahame Hardie, Isabelle Leclerc
Publikováno v:
Proceedings of the National Academy of Sciences. 97:4023-4028
Elevated glucose concentrations stimulate the transcription of the pre-proinsulin (PPI), L-type pyruvate kinase (L-PK), and other genes in islet beta cells. In liver cells, pharmacological activation by 5-amino-4-imidazolecarboxamide riboside (AICAR)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13aa2ad5b55939b79dac4fb41c02903a
https://doi.org/10.1073/pnas.97.8.4023
https://doi.org/10.1073/pnas.97.8.4023
Publikováno v:
Endocrine Reviews. 18:520-540
I. Introduction II. Transcriptional Regulation of Glucose-Responsive Genes A. The insulin gene 1. Glucose-signaling pathway in pancreas β-cells 2. E elements of the insulin gene promoter 3. A elements of the insulin gene promoter 4. Role of the E an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a476042c58ab942b975e7e630b56655
https://doi.org/10.1210/edrv.18.4.0307
https://doi.org/10.1210/edrv.18.4.0307
Publikováno v:
Journal of Biological Chemistry. 269:10213-10216
The L-type pyruvate kinase (L-PK) is a key enzyme of the glycolytic pathway mainly expressed in the liver. Rat liver contains a regulatory protein that inhibits glucokinase (GK) activity. The effect of this protein is greatly reinforced by the fructo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0ff02ef0d4eb52170595d12c535a777
https://doi.org/10.1016/s0021-9258(17)34047-4
https://doi.org/10.1016/s0021-9258(17)34047-4
Publikováno v:
Diabetologia. 55(3)
The physiological significance of growth factor receptor-bound protein-10 (GRB10) in the pancreas is unclear. We hypothesised that GRB10 is involved in pancreatic apoptosis, as GRB10 binds with a family of cell-survival-related proteins implicated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da71b8a35c203976177827151298458
https://pubmed.ncbi.nlm.nih.gov/22222503
https://pubmed.ncbi.nlm.nih.gov/22222503
Autor:
Bruno Doiron, Ralph A. DeFronzo
Publikováno v:
International Journal of Endocrinology & Metabolism. 9:356-357
In a recent article (Int J Endocrinol Metab 8:211-214, 2010), Hashemitabar et al. (1) have shown that intraperitoneal injection of metformin in pregnant mice induces an increase in the levels of Pdx-1 and insulin mRNA in neonatal mice but not in 19.5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cc42289a6e742d44e1ff00a9148dacc
https://doi.org/10.5812/kowsar.1726913x.2448
https://doi.org/10.5812/kowsar.1726913x.2448
Publikováno v:
International Journal of Sports Medicine. 12:187-189
The purpose of the present study was to compare the plasma insulin levels in portal and peripheral veins in rats submitted to a prolonged exercise to exhaustion (mean +/- SE: 67 +/- 7 min). Plasma insulin levels were reduced significantly (p less tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca190f56816ba14d76b66de03d238bbc
https://doi.org/10.1055/s-2007-1024665
https://doi.org/10.1055/s-2007-1024665
Publikováno v:
Biochemical Society transactions. 24(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7241d51737db66cf7c357a0a0bac7349
https://pubmed.ncbi.nlm.nih.gov/8736908
https://pubmed.ncbi.nlm.nih.gov/8736908
Publikováno v:
The Journal of biological chemistry. 271(10)
Glucose catabolism induces the expression of the L-type pyruvate kinase (L-PK) gene through the glucose response element (GIRE). The metabolic pathway used by glucose after its phosphorylation to glucose 6-phosphate by glucokinase to induce L-PK gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e097291735d4466b3c8685e4d4adb1eb
https://pubmed.ncbi.nlm.nih.gov/8621383
https://pubmed.ncbi.nlm.nih.gov/8621383