Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Bruno D Fonseca"'
Autor:
Roni M Lahr, Bruno D Fonseca, Gabrielle E Ciotti, Hiba A Al-Ashtal, Jian-Jun Jia, Marius R Niklaus, Sarah P Blagden, Tommy Alain, Andrea J Berman
Publikováno v:
eLife, Vol 6 (2017)
The 5’terminal oligopyrimidine (5’TOP) motif is a cis-regulatory RNA element located immediately downstream of the 7-methylguanosine [m7G] cap of TOP mRNAs, which encode ribosomal proteins and translation factors. In eukaryotes, this motif coordi
Externí odkaz:
https://doaj.org/article/52cd9152533a46c6bc990f5a688837bf
Autor:
Aruna D Balgi, Graham H Diering, Elizabeth Donohue, Karen K Y Lam, Bruno D Fonseca, Carla Zimmerman, Masayuki Numata, Michel Roberge
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21549 (2011)
BACKGROUND: Acidification of the cytoplasm and the extracellular environment is associated with many physiological and pathological conditions, such as intense exercise, hypoxia and tumourigenesis. Acidification affects important cellular functions i
Externí odkaz:
https://doaj.org/article/c22fa0367eae4705bf9c3904c72596e0
Autor:
Aruna D Balgi, Bruno D Fonseca, Elizabeth Donohue, Trevor C F Tsang, Patrick Lajoie, Christopher G Proud, Ivan R Nabi, Michel Roberge
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7124 (2009)
BACKGROUND:Mammalian target of rapamycin complex 1 (mTORC1) is a protein kinase that relays nutrient availability signals to control numerous cellular functions including autophagy, a process of cellular self-eating activated by nutrient depletion. A
Externí odkaz:
https://doaj.org/article/647f3f277aad48c4b8c4c845abe65350
Autor:
Nahum Sonenberg, Ivan Topisirovic, Yi Liu, Valentina Gandin, Lucie-Anne Voyer, Peter Metrakos, Victoria Marcus, Domenick Zammit, Mamatha Bhat, Nadeem Siddiqui, Akiko Yanagiya, Bruno D. Fonseca, Masahiro Morita, Tommy Alain
PDF file - 2.9MB, Figure S3 contains data that show that cells with elevated eIF4E expression exhibit resistance to asTORi. These data complement the main figures of the manuscript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741df993bd8ce1f83833e7b51c6479ad
https://doi.org/10.1158/0008-5472.22395990
https://doi.org/10.1158/0008-5472.22395990
Autor:
Nahum Sonenberg, Ivan Topisirovic, Yi Liu, Valentina Gandin, Lucie-Anne Voyer, Peter Metrakos, Victoria Marcus, Domenick Zammit, Mamatha Bhat, Nadeem Siddiqui, Akiko Yanagiya, Bruno D. Fonseca, Masahiro Morita, Tommy Alain
PDF file - 2.7MB, Figure S2 contains data that show that cells with reduced levels of 4E-BP1/2 have increased resistance to the anti-neoplastic effects of PP242.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089ebd7523754d0e243b489c1e8fb7ec
https://doi.org/10.1158/0008-5472.22395993
https://doi.org/10.1158/0008-5472.22395993
Autor:
Nahum Sonenberg, Ivan Topisirovic, Yi Liu, Valentina Gandin, Lucie-Anne Voyer, Peter Metrakos, Victoria Marcus, Domenick Zammit, Mamatha Bhat, Nadeem Siddiqui, Akiko Yanagiya, Bruno D. Fonseca, Masahiro Morita, Tommy Alain
PDF file - 101K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c1714beb66eda4194a1348d62f0bf3
https://doi.org/10.1158/0008-5472.22395981
https://doi.org/10.1158/0008-5472.22395981
Autor:
Nahum Sonenberg, Ivan Topisirovic, Yi Liu, Valentina Gandin, Lucie-Anne Voyer, Peter Metrakos, Victoria Marcus, Domenick Zammit, Mamatha Bhat, Nadeem Siddiqui, Akiko Yanagiya, Bruno D. Fonseca, Masahiro Morita, Tommy Alain
PDF file - 2.3MB, Figure S4 contains data that show that the eIF4E/4E-BP ratio influences the antiproliferative efficacy of asTORi.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df800fd6ec4530a5d07d5f4583a6420
https://doi.org/10.1158/0008-5472.22395987.v1
https://doi.org/10.1158/0008-5472.22395987.v1
Autor:
Nahum Sonenberg, Ivan Topisirovic, Yi Liu, Valentina Gandin, Lucie-Anne Voyer, Peter Metrakos, Victoria Marcus, Domenick Zammit, Mamatha Bhat, Nadeem Siddiqui, Akiko Yanagiya, Bruno D. Fonseca, Masahiro Morita, Tommy Alain
PDF file - 2.1MB, Figure S1 contains data that show that cells acquire resistance to the anti-proliferative effects of PP242 by downregulating 4E-BP1 and 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90938a63dda32d0d16e43d30401ef562
https://doi.org/10.1158/0008-5472.22395996.v1
https://doi.org/10.1158/0008-5472.22395996.v1
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The eIF4E-binding proteins (4E-BPs) are critical repressors of cap-dependent translation via mTOR, a pathway frequently hyperactivated in cancer. Here the authors show that 4E-BP3 specifically mediates the cap-dependent translation repression and ant
Externí odkaz:
https://doaj.org/article/ee562b6abcf44f1eadff64ef32118520
Autor:
Kalle Gehring, Guennadi Kozlov, Richard J. Maraia, Bruno D. Fonseca, Sergei Gaidamakov, Sandy Mattijssen, Amitabh Ranjan
Publikováno v:
RNA Biol
The protein domain arrangement known as the La-module, comprised of a La motif (LaM) followed by a linker and RNA recognition motif (RRM), is found in seven La-related proteins: LARP1, LARP1B, LARP3 (La protein), LARP4, LARP4B, LARP6, and LARP7 in hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d7976e99ad1b46f774f064e2388fc08
https://doi.org/10.1080/15476286.2020.1860376
https://doi.org/10.1080/15476286.2020.1860376