Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Bruno D Fonseca"'
Autor:
Nahum Sonenberg, Ivan Topisirovic, Yi Liu, Valentina Gandin, Lucie-Anne Voyer, Peter Metrakos, Victoria Marcus, Domenick Zammit, Mamatha Bhat, Nadeem Siddiqui, Akiko Yanagiya, Bruno D. Fonseca, Masahiro Morita, Tommy Alain
PDF file - 2.9MB, Figure S3 contains data that show that cells with elevated eIF4E expression exhibit resistance to asTORi. These data complement the main figures of the manuscript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741df993bd8ce1f83833e7b51c6479ad
https://doi.org/10.1158/0008-5472.22395990
https://doi.org/10.1158/0008-5472.22395990
Autor:
Nahum Sonenberg, Ivan Topisirovic, Yi Liu, Valentina Gandin, Lucie-Anne Voyer, Peter Metrakos, Victoria Marcus, Domenick Zammit, Mamatha Bhat, Nadeem Siddiqui, Akiko Yanagiya, Bruno D. Fonseca, Masahiro Morita, Tommy Alain
PDF file - 2.7MB, Figure S2 contains data that show that cells with reduced levels of 4E-BP1/2 have increased resistance to the anti-neoplastic effects of PP242.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089ebd7523754d0e243b489c1e8fb7ec
https://doi.org/10.1158/0008-5472.22395993
https://doi.org/10.1158/0008-5472.22395993
Autor:
Nahum Sonenberg, Ivan Topisirovic, Yi Liu, Valentina Gandin, Lucie-Anne Voyer, Peter Metrakos, Victoria Marcus, Domenick Zammit, Mamatha Bhat, Nadeem Siddiqui, Akiko Yanagiya, Bruno D. Fonseca, Masahiro Morita, Tommy Alain
PDF file - 101K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c1714beb66eda4194a1348d62f0bf3
https://doi.org/10.1158/0008-5472.22395981
https://doi.org/10.1158/0008-5472.22395981
Autor:
Nahum Sonenberg, Ivan Topisirovic, Yi Liu, Valentina Gandin, Lucie-Anne Voyer, Peter Metrakos, Victoria Marcus, Domenick Zammit, Mamatha Bhat, Nadeem Siddiqui, Akiko Yanagiya, Bruno D. Fonseca, Masahiro Morita, Tommy Alain
PDF file - 2.3MB, Figure S4 contains data that show that the eIF4E/4E-BP ratio influences the antiproliferative efficacy of asTORi.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df800fd6ec4530a5d07d5f4583a6420
https://doi.org/10.1158/0008-5472.22395987.v1
https://doi.org/10.1158/0008-5472.22395987.v1
Autor:
Nahum Sonenberg, Ivan Topisirovic, Yi Liu, Valentina Gandin, Lucie-Anne Voyer, Peter Metrakos, Victoria Marcus, Domenick Zammit, Mamatha Bhat, Nadeem Siddiqui, Akiko Yanagiya, Bruno D. Fonseca, Masahiro Morita, Tommy Alain
PDF file - 2.1MB, Figure S1 contains data that show that cells acquire resistance to the anti-proliferative effects of PP242 by downregulating 4E-BP1 and 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90938a63dda32d0d16e43d30401ef562
https://doi.org/10.1158/0008-5472.22395996.v1
https://doi.org/10.1158/0008-5472.22395996.v1
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The eIF4E-binding proteins (4E-BPs) are critical repressors of cap-dependent translation via mTOR, a pathway frequently hyperactivated in cancer. Here the authors show that 4E-BP3 specifically mediates the cap-dependent translation repression and ant
Externí odkaz:
https://doaj.org/article/ee562b6abcf44f1eadff64ef32118520
Autor:
Roni M Lahr, Bruno D Fonseca, Gabrielle E Ciotti, Hiba A Al-Ashtal, Jian-Jun Jia, Marius R Niklaus, Sarah P Blagden, Tommy Alain, Andrea J Berman
Publikováno v:
eLife, Vol 6 (2017)
The 5’terminal oligopyrimidine (5’TOP) motif is a cis-regulatory RNA element located immediately downstream of the 7-methylguanosine [m7G] cap of TOP mRNAs, which encode ribosomal proteins and translation factors. In eukaryotes, this motif coordi
Externí odkaz:
https://doaj.org/article/52cd9152533a46c6bc990f5a688837bf
Autor:
Kalle Gehring, Guennadi Kozlov, Richard J. Maraia, Bruno D. Fonseca, Sergei Gaidamakov, Sandy Mattijssen, Amitabh Ranjan
Publikováno v:
RNA Biol
The protein domain arrangement known as the La-module, comprised of a La motif (LaM) followed by a linker and RNA recognition motif (RRM), is found in seven La-related proteins: LARP1, LARP1B, LARP3 (La protein), LARP4, LARP4B, LARP6, and LARP7 in hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d7976e99ad1b46f774f064e2388fc08
https://doi.org/10.1080/15476286.2020.1860376
https://doi.org/10.1080/15476286.2020.1860376
Autor:
Joseph A. Waldron, Ania Wilczynska, Katherine Morris, Mark Stoneley, Kelvin Cain, Martin Bushell, Nour El Houda Benbahouche, Ewan M. Smith, Rebekah Jukes-Jones, Cameron Bell, Bruno D. Fonseca, Sarah P. Blagden, Carolyn Jones, Hedda A. Meijer, Sarah L. Gillen, Anne E. Willis, Tobias Schmidt
Publikováno v:
Nucleic Acids Research
The mammalian target of rapamycin (mTOR) is a critical regulator of cell growth, integrating multiple signalling cues and pathways. Key among the downstream activities of mTOR is the control of the protein synthesis machinery. This is achieved, in pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d83d08c5e22eaca2d556c4155e269f4
https://doi.org/10.1093/nar/gkaa1189
https://doi.org/10.1093/nar/gkaa1189
Autor:
Zeenat Farooq, Fedho Kusuma, Phillip Burke, Catherine R. Dufour, Duckgue Lee, Negar Tabatabaei, Phoenix Toboz, Ernest Radovani, Jack F. Greenblatt, Jalees Rehman, Jacob Class, Arkady Khoutorsky, Bruno D. Fonseca, Justin M. Richner, Eloi Mercier, Guillaume Bourque, Vincent Giguère, Arvind R. Subramaniam, Jaeseok Han, Soroush Tahmasebi
Publikováno v:
The Journal of biological chemistry. 298(9)
La-related protein 1 (LARP1) has been identified as a key translational inhibitor of terminal oligopyrimidine (TOP) mRNAs downstream of the nutrient sensing protein kinase complex, mTORC1. LARP1 exerts this inhibitory effect on TOP mRNA translation b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37cb6b06e10cf5fe5e40da535fda28c1
https://pubmed.ncbi.nlm.nih.gov/35863436
https://pubmed.ncbi.nlm.nih.gov/35863436