Cardiac expression of ryanodine receptor subtype 3; a strategic component in the intracellular Ca2+ release system of Purkinje fibers in large mammalian heart

Autor: Bruno D. Stuyvers, Rebecca E. Daniels, John J. McGuire, Vincenzo Sorrentino, Elizabeth W. Chia, Kazi T. Haq, Masahito Miura, Lawson Miller

Publikováno v: Journal of Molecular and Cellular Cardiology. 104:31-42

Background Three distinct Ca 2 + release channels were identified in dog P-cells: the ryanodine receptor subtype 2 ( RyR2 ) was detected throughout the cell, while the ryanodine receptor subtype 3 ( RyR3 ) and inositol phosphate sensitive Ca 2 + rele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6181675c38fd39e45f8b496f462fc6a
https://doi.org/10.1016/j.yjmcc.2017.01.011

Ventricular arrhythmias and the His–Purkinje system

Autor: Olivier Bernus, Edward J. Vigmond, Michel Haïssaguerre, Mélèze Hocini, Bruno D. Stuyvers

Publikováno v: Nature Reviews Cardiology. 13:155-166

Ventricular arrhythmias are a major cause of sudden death, which accounts for approximately half of cardiac mortality. The His-Purkinje system is composed of specialized cells responsible for the synchronous activation of the ventricles. However, exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6edaaed458bef7de63731d649d6e2297
https://doi.org/10.1038/nrcardio.2015.193

Release kinetics of circulating cardiac myosin binding protein-C following cardiac injury

Autor: Karen S. Pieper, Sakthivel Sadayappan, Bruno D. Stuyvers, Christian W. Hamm, Neal S. Kleiman, Kenneth W. Mahaffey, Helge Möllmann, Holger Nef, Christoph Liebetrau, Adriana Cardenas-Ospina, Ali J. Marian, Christian Troidl, Diederik W. D. Kuster, Lawson Miller

Publikováno v: American Journal of Physiology. Heart and Circulatory Physiology, 306(4), H547-H556. American Physiological Society
Kuster, D W D, Cardenas-Ospina, A, Miller, L, Liebetrau, C, Troidl, C, Nef, H M, Moellmann, H, Hamm, C W, Pieper, K S, Mahaffey, K W, Kleiman, N S, Stuyvers, B D, Marian, A J & Sadayappan, S 2014, ' Release kinetics of circulating cardiac myosin binding protein-C following cardiac injury ', American Journal of Physiology. Heart and Circulatory Physiology, vol. 306, no. 4, pp. H547-H556 . https://doi.org/10.1152/ajpheart.00846.2013

Diagnosis of myocardial infarction (MI) is based on ST-segment elevation on electrocardiographic evaluation and/or elevated plasma cardiac troponin (cTn) levels. However, troponins lack the sensitivity required to detect the onset of MI at its earlie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9e56da942b7b3d55d168c275d7e730
https://doi.org/10.1152/ajpheart.00846.2013

Cardiac expression of ryanodine receptor subtype 3; a strategic component in the intracellular Ca

Autor: Rebecca E, Daniels, Kazi T, Haq, Lawson S, Miller, Elizabeth W, Chia, Masahito, Miura, Vincenzo, Sorrentino, John J, McGuire, Bruno D, Stuyvers

Publikováno v: Journal of molecular and cellular cardiology. 104

Three distinct CaGene expression of CR channels was measured by qPCR in Purkinje fibers and myocardium of adult Yucatan pig hearts. We characterized the CR channels protein expression in isolated P-cells by immuno-fluorescence, laser scanning confoca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4a3ceb053d278bd8352a3d1ccc8f3ec0
https://pubmed.ncbi.nlm.nih.gov/28111173

Effect of Nonuniform Muscle Contraction on Sustainability and Frequency of Triggered Arrhythmias in Rat Cardiac Muscle

Autor: Penelope A. Boyden, Taiki Hattori, Bruno D. Stuyvers, Masahito Miura, Chiyohiko Shindoh, Naomi Murai, Taichi Nishio

Publikováno v: Circulation. 121:2711-2717

Background— Arrhythmias are benign or lethal, depending on their sustainability and frequency. To determine why lethal arrhythmias are prone to occur in diseased hearts, usually characterized by nonuniform muscle contraction, we investigated the ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c03c6ec04153d4c6158c8474670d2c
https://doi.org/10.1161/circulationaha.109.907717