Zobrazeno 1 - 10
of 246
pro vyhledávání: '"Bruno Calabretta"'
Autor:
Luca Pagliaroli, Patrizia Porazzi, Alyxandra T. Curtis, Chiara Scopa, Harald M. M. Mikkers, Christian Freund, Lucia Daxinger, Sandra Deliard, Sarah A. Welsh, Sarah Offley, Connor A. Ott, Bruno Calabretta, Samantha A. Brugmann, Gijs W. E. Santen, Marco Trizzino
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Mutations in the ARID1B subunit of the BAF chromatin remodeling complex are associated with the neurodevelopmental Coffin-Siris syndrome. Here the authors reveal that there is a transition from ARID1A-containing complexes to ARID1B during cranial neu
Externí odkaz:
https://doaj.org/article/d81d9aec3d4b4606a4380fcc57816cd2
Autor:
Simona D’Aguanno, Elisabetta Valentini, Maria Grazia Tupone, Marianna Desideri, Marta Di Martile, Manuela Spagnuolo, Simonetta Buglioni, Cristiana Ercolani, Italia Falcone, Marco De Dominici, Michele Milella, Maria Giulia Rizzo, Bruno Calabretta, Carlo Cota, Andrea Anichini, Daniela Trisciuoglio, Donatella Del Bufalo
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-14 (2018)
Abstract Background Melanoma, the most aggressive form of skin cancer, is characterized by high rates of metastasis, drug resistance and mortality. Here we investigated the role of Semaphorin 5A (Sema5A) on the properties associated with melanoma pro
Externí odkaz:
https://doaj.org/article/4a194598930f43328183ca75cc21ea0a
Publikováno v:
Genes, Vol 12, Iss 9, p 1355 (2021)
Ph+ ALL is a poor-prognosis leukemia subtype driven by the BCR-ABL1 oncogene, either the p190- or the p210-BCR/ABL isoform in a 70:30 ratio. Tyrosine Kinase inhibitors (TKIs) are the drugs of choice in the therapy of Ph+ ALL. In combination with stan
Externí odkaz:
https://doaj.org/article/4a7135e0cc8742c7b10f97cca257b4bc
Autor:
Svetlana Petruk, Samanta A. Mariani, Marco De Dominici, Patrizia Porazzi, Valentina Minieri, Jingli Cai, Lorraine Iacovitti, Neal Flomenberg, Bruno Calabretta, Alexander Mazo
Publikováno v:
Cell Reports, Vol 19, Iss 2, Pp 295-306 (2017)
Summary: The role of chromatin structure in lineage commitment of multipotent hematopoietic progenitors (HPCs) is presently unclear. We show here that CD34+ HPCs possess a post-replicative chromatin globally devoid of the repressive histone mark H3K2
Externí odkaz:
https://doaj.org/article/5bd388368332412081472e38aff5b32a
Autor:
Manuela Spagnuolo, Giulia Regazzo, Marco De Dominici, Andrea Sacconi, Andrea Pelosi, Etleva Korita, Francesco Marchesi, Francesco Pisani, Alessandra Magenta, Valentina Lulli, Iole Cordone, Andrea Mengarelli, Sabrina Strano, Giovanni Blandino, Maria G. Rizzo, Bruno Calabretta
Publikováno v:
Haematologica, Vol 104, Iss 1 (2019)
MicroRNAs, non-coding regulators of gene expression, are likely to function as important downstream effectors of many transcription factors including MYB. Optimal levels of MYB are required for transformation/maintenance of BCR-ABL-expressing cells.
Externí odkaz:
https://doaj.org/article/58e34c144a5b494593c5bd815ea7007b
Autor:
Giovanna Ferrari-Amorotti, Claudia Chiodoni, Fei Shen, Sara Cattelani, Angela Rachele Soliera, Gloria Manzotti, Giulia Grisendi, Massimo Dominici, Francesco Rivasi, Mario Paolo Colombo, Alessandro Fatatis, Bruno Calabretta
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 12, Pp 1047-1058 (2014)
Most triple-negative breast cancers (TNBCs) exhibit gene expression patterns associated with epithelial-to-mesenchymal transition (EMT), a feature that correlates with a propensity for metastatic spread. Overexpression of the EMT regulator Slug is de
Externí odkaz:
https://doaj.org/article/a77b33130f67494ab68695c56d8e7eaa
Autor:
Sara Cattelani, Giovanna Ferrari-Amorotti, Sara Galavotti, Raffaella Defferrari, Barbara Tanno, Samantha Cialfi, Jenny Vergalli, Valentina Fragliasso, Clara Guerzoni, Gloria Manzotti, Angela Rachele Soliera, Chiara Menin, Roberta Bertorelle, Heather P. McDowell, Alessandro Inserra, Maria Luisa Belli, Luigi Varesio, Deborah Tweddle, Gian Paolo Tonini, Pierluigi Altavista, Carlo Dominici, Giuseppe Raschellà, Bruno Calabretta
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 7, Pp 634-643 (2012)
The p53 gene is rarely mutated in neuroblastoma, but codon 72 polymorphism that modulates its proapoptotic activity might influence cancer risk and clinical outcome. We investigated whether this polymorphism affects neuroblastoma risk and disease out
Externí odkaz:
https://doaj.org/article/a82fdf1e4a494fedb36b4d5a5686f82e
Autor:
Marja T. Nevalainen, Bruno Calabretta, Nagarajan Pattabiraman, Vincent Njar, Gino Cingolani, Leonard G. Gomella, David T. Hoang, Hallgeir Rui, Guanjun Xia, Benjamin Leiby, Paolo Fortina, Adam Ertel, Shauna Blackmon, Elyse Ellsworth, Shilpa Gupta, Costas D. Lallas, Edouard Trabulsi, Peter A. McCue, Puranik Purushottamachar, Ayush Dagvadorj, Ravi K. Lokareddy, Marco De Dominici, Samanta A. Mariani, Jenny Vergalli, Lei Gu, Zhiyong Liao
Supplementary Table 4: Genes down-regulated (> 2-fold) by Stat5-shRNA and IST5-002 in K562
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b04c76a8e28cb2743713cf60d3ca3b6
https://doi.org/10.1158/1535-7163.22501908.v1
https://doi.org/10.1158/1535-7163.22501908.v1
Autor:
Marja T. Nevalainen, Bruno Calabretta, Nagarajan Pattabiraman, Vincent Njar, Gino Cingolani, Leonard G. Gomella, David T. Hoang, Hallgeir Rui, Guanjun Xia, Benjamin Leiby, Paolo Fortina, Adam Ertel, Shauna Blackmon, Elyse Ellsworth, Shilpa Gupta, Costas D. Lallas, Edouard Trabulsi, Peter A. McCue, Puranik Purushottamachar, Ayush Dagvadorj, Ravi K. Lokareddy, Marco De Dominici, Samanta A. Mariani, Jenny Vergalli, Lei Gu, Zhiyong Liao
Supplementary Methods. Supplementary Figure 1. Chemical structures of the small molecule IST5-002 analogs. Supplementary Figure 2. IST5-002 inhibits phosphorylation of Stat5 in mouse and human breast cancer cells. Supplementary Figure 3. IST5-002 doe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e3dfff6a37fe75ab4144213045f901
https://doi.org/10.1158/1535-7163.22501902.v1
https://doi.org/10.1158/1535-7163.22501902.v1
Autor:
Marja T. Nevalainen, Bruno Calabretta, Nagarajan Pattabiraman, Vincent Njar, Gino Cingolani, Leonard G. Gomella, David T. Hoang, Hallgeir Rui, Guanjun Xia, Benjamin Leiby, Paolo Fortina, Adam Ertel, Shauna Blackmon, Elyse Ellsworth, Shilpa Gupta, Costas D. Lallas, Edouard Trabulsi, Peter A. McCue, Puranik Purushottamachar, Ayush Dagvadorj, Ravi K. Lokareddy, Marco De Dominici, Samanta A. Mariani, Jenny Vergalli, Lei Gu, Zhiyong Liao
Supplementary Table 3: Genes up-regulated (> 2-fold) by Stat5-shRNA and IST5-002 in K562
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b280acfc4448d6042e6bbbb7c7ad3891
https://doi.org/10.1158/1535-7163.22501914
https://doi.org/10.1158/1535-7163.22501914